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Medical Forum / General / Nutrition / November 2005

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Omega 3 Fatty Acid Overdose?

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rfw@mailandnews.com - 20 Nov 2005 01:49 GMT
I'm currently take about 6000mg EPA/3000mg DHA per day(15 softgels). I
have been taking this dosage for about a year and a half because my bad
cholesterol level was out of control.

The only side effect that I've suffered is a lowered sex drive - which
I was warned about ahead of time.  Are there any other side effects
that i could suffer from taking such high dosages??
Matti Narkia - 20 Nov 2005 02:20 GMT
19 Nov 2005 17:49:23 -0800 in article
<1132451363.186002.216430@g14g2000cwa.googlegroups.com> rfw@mailandnews.com
wrote:

>I'm currently take about 6000mg EPA/3000mg DHA per day(15 softgels). I
>have been taking this dosage for about a year and a half because my bad
[quoted text clipped - 3 lines]
>I was warned about ahead of time.  Are there any other side effects
>that i could suffer from taking such high dosages??

Strange. Apparently this has hardly been researched at all. One study I
found cited an opposite, positive effect on libido by ethyl-EPA, but that
was with depressed patients:

Peet M, Horrobin DF
A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients
with ongoing depression despite apparently adequate treatment with standard
drugs.
Arch Gen Psychiatry. 2002 Oct;59(10):913-9.
PMID: 12365878 [PubMed - indexed for MEDLINE]
<http://archpsyc.ama-assn.org/cgi/content/full/59/10/913>

   "On all 20 items of the BDI, the 1-g/d dosage was better than placebo,
   with particularly large and significant differences for sadness,
   pessimism, inability to work, sleep disturbances, and libido."

Signature

Matti Narkia

Matti Narkia - 20 Nov 2005 02:37 GMT
19 Nov 2005 17:49:23 -0800 in article
<1132451363.186002.216430@g14g2000cwa.googlegroups.com> rfw@mailandnews.com
wrote:

>I'm currently take about 6000mg EPA/3000mg DHA per day(15 softgels). I
>have been taking this dosage for about a year and a half because my bad
>cholesterol level was out of control.

If this is your only way to attempt to control cholesterol, it sounds a bit
one-sided, IMHO. Have you tried any other dietary approaces? There are quite
a number of options available. Some of them can be found here:

Cholesterol Reduction: Online References For Health Concerns
<http://www.lef.org/LEFCMS/aspx/PrintVersionMagic.aspx?CmsID=40210>
<http://www.lef.org/protocols/prtcl-032.shtml>

See also

Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Wong JM, de Souza R, Emam
A, Parker TL, Vidgen E, Lapsley KG, Trautwein EA, Josse RG, Leiter LA,
Connelly PW.
Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin
on serum lipids and C-reactive protein.
JAMA. 2003 Jul 23;290(4):502-10.
PMID: 12876093 [PubMed - indexed for MEDLINE
<http://jama.ama-assn.org/cgi/content/full/290/4/502>
(Comments in
Diet First, Then Medication for Hypercholesterolemia
James W. Anderson
JAMA. 2003;290:531-533.
<http://jama.ama-assn.org/cgi/content/full/290/4/531>
and
Vegetarian diet may work as well as cholesterol drugs
<http://www.usatoday.com/news/health/2003-07-23-cholesterol_x.htm>)

and

Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA.
Cinnamon improves glucose and lipids of people with type 2 diabetes.
Diabetes Care. 2003 Dec;26(12):3215-8.
<http://care.diabetesjournals.org/cgi/content/full/26/12/3215>
(Commented in the article
"Cinnamon spice produces healthier blood"
<http://www.newscientist.com/news/news.jsp?id=ns99994413>

Also recommended reading:

Mukuddem-Petersen J, Oosthuizen W, Jerling JC.
A systematic review of the effects of nuts on blood lipid profiles in
humans.
J Nutr. 2005 Sep;135(9):2082-9.
PMID: 16140880 [PubMed - in process]
<http://www.nutrition.org/cgi/content/abstract/135/9/2082>

Sabate J, Haddad E, Tanzman JS, Jambazian P, Rajaram S.
Serum lipid response to the graduated enrichment of a Step I diet with
almonds: a randomized feeding trial.
Am J Clin Nutr. 2003 Jun;77(6):1379-84.
PMID: 12791613 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/full/77/6/1379>

Hyson DA, Schneeman BO, Davis PA
Almonds and almond oil have similar effects on plasma lipids and LDL
oxidation in healthy men and women.
J Nutr. 2002 Apr;132(4):703-7.
PMID: 11925464 [PubMed - indexed for MEDLINE]
<http://www.nutrition.org/cgi/content/full/132/4/703>

Jenkins DJ, Kendall CW, Marchie A, Parker TL, Connelly PW, Qian W, Haight
JS, Faulkner D, Vidgen E, Lapsley KG, Spiller GA
Dose response of almonds on coronary heart disease risk factors: blood
lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and
pulmonary nitric oxide: a randomized, controlled, crossover trial.
Circulation. 2002 Sep 10;106(11):1327-32.
PMID: 12221048 [PubMed - indexed for MEDLINE]
<http://circ.ahajournals.org/cgi/content/full/106/11/1327>

Almario RU, Vonghavaravat V, Wong R, Kasim-Karakas SE.
Effects of walnut consumption on plasma fatty acids and lipoproteins in
combined hyperlipidemia.
Am J Clin Nutr. 2001 Jul;74(1):72-9.
PMID: 11451720 [PubMed - indexed for MEDLINE]
<http://www.ajcn.org/cgi/content/full/74/1/72>

Tapsell LC, Gillen LJ, Patch CS, Batterham M, Owen A, Bare M, Kennedy M.
Including walnuts in a low-fat/modified-fat diet improves HDL
cholesterol-to-total cholesterol ratios in patients with type 2 diabetes.
Diabetes Care. 2004 Dec;27(12):2777-83.
PMID: 15562184 [PubMed - indexed for MEDLINE]
<http://care.diabetesjournals.org/cgi/content/full/27/12/2777>

Fats and Cholesterol
<http://www.hsph.harvard.edu/nutritionsource/fats.html>

Food Pyramids:  Nutrition Source, Harvard School of Public Health
<http://www.hsph.harvard.edu/nutritionsource/pyramids.html>

Harvard School of Public Health Nutrition Source
<http://www.hsph.harvard.edu/nutritionsource/index.html

Signature

Matti Narkia

montygram - 20 Nov 2005 06:34 GMT
Yes, you may kill yourself taking these toxic substances, as I almost
did a few years back.  Search this newsgroup for montygram and you can
read my previous posts on this subject. You can also read a decent book
about many of the issues I cover.  It's called Saturated fat may save
your life, by Bruce Fife, and it is written in a non-technical way but
includes a large number of citations from the scientific literature.  I
don't know the man personally and have no connections to him or his
enterprises.  My services are free of charge, with no obligations of
any kind.  Just make a new post with montygram in the title, such as
Montygram: why is fish oil so toxic? and I'll explain it and cite the
evidence.  But please read my older posts first, because it's all
there.  Then, if you still don't explain something, ask your questions.
MMu - 21 Nov 2005 09:13 GMT
> I'm currently take about 6000mg EPA/3000mg DHA per day(15 softgels).

May I ask why you take these supplements?

You are taking a quite high dose of EPA/DHA and this is way beyond the
purely nutritional value alone..
I would definitely not recommend to take such high doses of omega 3
supplements, and neither does your government probably [recommendation in
the US is about 2g/day omega 3 maximum]. You can overdose on PUFA.

Read here for the why's: http://en.wikipedia.org/wiki/Omega-3_fatty_acid

I'd rather recommend you try food sources naturally rich in EPA/DHA and eat
some vegetables to that.
John Sankey - 28 Nov 2005 14:39 GMT
There have been several reports of people taking similar doses
to combat cancer, with no side effects being mentioned.

Still, I agree that there are many ways to combat abnormally
high serum cholesterol and you should be using several of them,
rather than going to the limit on just one. See
http://sankey.ws/cholesterol.html
for a few links and my experience.
 
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