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Medical Forum / General / Nutrition / August 2005glutathione supplement
hello i need more informations about GSH supplementation. In the link discution (http://yarchive.net/med/glutathione.html) it's said that extracellular glutathione is not needed and to increase it by supplementation is waste of money. i've found others article which explain the opposite: http://members.tripod.com/uvicf/gsh/layman_gsh.htm Anyone can give more info about GSH intestinal absorption? Is liposomal GSH really effective? cyril >i need more informations about GSH supplementation. > [quoted text clipped - 7 lines] >Anyone can give more info about GSH intestinal absorption? >Is liposomal GSH really effective? Because of the absorption controversy, I prefer to take glutathione precursors. Among these, N-Acetyl-Cysteine appears to be the most important one. I take roughly 2g/day of NAC together with 4g of Vit. C as recommended by LEF: http://www.lef.org/newshop/items/item00215.html > hello > [quoted text clipped - 11 lines] > > cyril The best way to increase your glutathione levels is by eating Sulfur rich foods: eggs (among the best sources of sulfur), whole cow's milk, meats, cheese, broccoli, cauliflower, kale, brussel sprouts, watercress, radish, leek, horseradish, mustard leaves, onion, and garlic.  SignatureDawid Michalczyk http://www.art.eonworks.com - Art and Illustration Free Radic Biol Med. 2004 Oct 1;37(7):953-60. Related Articles, Links Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells. Nunez MT, Gallardo V, Munoz P, Tapia V, Esparza A, Salazar J, Speisky H. Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile. Glutathione (GSH) constitutes the single most important antioxidant in neurons, whereas iron causes oxidative stress that leads to cell damage and death. Although GSH and iron produce opposite effects on redox cell status, no mechanistic relationships between iron and GSH metabolism are known. In this work, we evaluated in SH-SY5Y neuroblastoma cells the effects of iron accumulation on intracellular GSH metabolism. After 2 d exposure to increasing concentrations of iron, cells underwent concentration-dependent iron accumulation and a biphasic change in intracellular GSH levels. Increasing iron from 1 to 5 microM resulted in a marked increase in intracellular oxidative stress and increased GSH levels. Increased GSH levels were due to increased synthesis. Further increases in iron concentration led to significant reduction in both reduced (GSH) and total (GSH + (2 x GSSG)) glutathione. Cell exposure to high iron concentrations (20-80 microM) was associated with a marked decrease in the GSH/GSSG molar ratio and the GSH half-cell reduction potential. Moreover, increasing iron from 40 to 80 microM resulted in loss of cell viability. Iron loading did not change GSH reductase activity but induced significant increases in GSH peroxidase and GSH transferase activities. The changes in GSH homeostasis reported here recapitulate several of those observed in Parkinson's disease substantia nigra. These results support a model by which progressive iron accumulation leads to a progressive decrease in GSH content and cell reduction potential, which finally results in impaired cell integrity. PMID: 15336311 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Glutathione raised by phlebotomy / bloodletting .. Could it be somehow linked to .. erythropoietin .. ? Comp Biochem Physiol B. 1983;75(1):5-8. Related Articles, Links Effect of experimental anaemia on red cell GSH and enzyme activities in guinea-pig and rabbit. Suzuki M, Kataoka T. 1. The effect of experimental anaemia on red cell GSH and enzyme activities of GSH-Px, GSSG-R and G6PD was investigated in guinea-pig and rabbit. 2. The anaemia was induced by injection of PHH in guinea-pig and rabbit and also by bleeding in guinea-pig. 3. Red cell GSH increased from 115.5 to 141.8 mg/dl RBC in the guinea-pig and from 108.5 to 133.5 mg/dl RBC in the rabbit during anaemia. 4. There were significant rises in the level of all the three enzymes activities in both the species of animals. However, the changes in rabbit were more pronounced than in the guinea-pig. PMID: 6851486 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- 1: Aust J Biol Sci. 1975 Jun;28(3):233-8. Related Articles, Links The effect of experimental anaemia on the levels of glutathione and glycolytic enzymes of the erythrocytes of normal and glutathione-deficient Merino sheep. Agar NS, Roberts J, Mulley A, Board PG, Harley JD. The effects of experimental anaemia on the levels of reduced glutathione (GSH) and the activity of glycolytic enzymes in the erythrocytes of normal and GSH-deficient Merino sheep were investigated. There was a rise in red cell GSH levels in both groups of sheep; the magnitude of this response was, however, quite different. When expressed as a percentage of the initial value, the rise in GSH level was 18% in normal and 263% in GSH-deficient animals. There was also an increase in the activities of various enzymes following phlebotomy but this increase was similar in the two groups of sheep. PMID: 126681 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking "Glutathione raised by phlebotomy / bloodletting .. Could it be somehow linked to .. erythropoietin .. ?" No, in science when our notions fail we turn from them to find the truth. If you want to increase it, eat whey. A good example of the min, opt, max process. An increase in iron increased glutathione, a max dose was rlated to a lowering of it. Biology is not a black or white thing, the whole picture must be considered not bits and pieces of non related posting of abstracts not comprehended in the first instance. |
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