Medical Forum / General / Nutrition / June 2005
Milk & insulin resistance
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Juhana Harju - 24 Jun 2005 06:25 GMT A new study associates avoiding milk with reduced risk of insulin resistance and metabolic syndrome in elderly women.
Diabet Med. 2005 Jun;22(6):808-11. Related Articles, Links
Avoiding milk is associated with a reduced risk of insulin resistance and the metabolic syndrome: findings from the British Women's Heart and Health Study.
Lawlor DA, Ebrahim S, Timpson N, Davey Smith G.
Department of Social Medicine, University of Bristol, Canynge Hall, Bristol, UK.
OBJECTIVE: To examine the association of milk consumption with insulin resistance and the metabolic syndrome. METHODS: The association was examined in 4024 British women aged 60-79 who were randomly selected from primary care centres in 23 towns. RESULTS: Women who never drank milk had lower homeostasis model assessment insulin resistance (HOMA) scores, triglyceride concentrations and body mass indices, and higher high-density lipoprotein (HDL)-cholesterol concentrations, than those who drank milk. The age-adjusted odds ratio for the metabolic syndrome comparing non-milk drinkers with drinkers was 0.55 (0.33, 0.94), which did not attenuate with adjustment for potential confounders. Diabetes was less common in non-milk drinkers. CONCLUSION: Individuals who do not drink milk may be protected against insulin resistance and the metabolic syndrome. However, randomized controlled trials are required to establish whether milk avoidance is causally associated with these outcomes. PMID: 15910636
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15910636&query_hl=3
 Signature Juhana
Juhana Harju - 24 Jun 2005 06:30 GMT :: A new study associates avoiding milk with reduced risk of insulin :: resistance and metabolic syndrome in elderly women. [quoted text clipped - 26 lines] :: required to establish whether milk avoidance is causally associated :: with these outcomes. PMID: 15910636 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15910636&query_hl=3
The free full study is available here:
http://www.epi.bris.ac.uk/staff/gdaveysmith/pdf/P485%20Avoiding.pdf
 Signature Juhana
nospam@aol.com - 24 Jun 2005 07:11 GMT >:: A new study associates avoiding milk with reduced risk of insulin >:: resistance and metabolic syndrome in elderly women. [quoted text clipped - 32 lines] > >http://www.epi.bris.ac.uk/staff/gdaveysmith/pdf/P485%20Avoiding.pdf Very interesting study. I noticed that those who did not drink milk had considerably higher prevalence of hip fractures.
Osteoporosis and fractures milk no milk Osteoporosis (%) 7.8 (7.0, 8.7) 12.4 (7.5, 19.9) 0.07 Ever had wrist or hip fracture (%) 13.6 (12.6, 14.8) 21.1 (14.5, 29.7) 0.02
Ora
Juhana Harju - 24 Jun 2005 07:40 GMT ::: Juhana Harju wrote:
::::: A new study associates avoiding milk with reduced risk of insulin ::::: resistance and metabolic syndrome in elderly women. [quoted text clipped - 15 lines] ::::: do not drink milk may be protected against insulin resistance and ::::: the metabolic syndrome. [...] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15910636&query_hl=3
::: The free full study is available here: ::: [quoted text clipped - 7 lines] :: Ever had wrist or hip fracture (%) 13.6 (12.6, 14.8) 21.1 (14.5, :: 29.7) 0.02 That is correct. Please notice that the women in the non-milk group used very little calcium supplementation and the vitamin D supplementation is not known. Nor did I found any data of the consumption of other dairy products in the non-milk drinker group, which would have been interesting to know.
Personally I do not drink milk but I eat plain yogurt and goat cheese.
 Signature Juhana
nospam@aol.com - 24 Jun 2005 07:52 GMT >::: Juhana Harju wrote: > [quoted text clipped - 38 lines] > >Personally I do not drink milk but I eat plain yogurt and goat cheese. The non-milk drinkers used more calcium supplementation than the milk drinkers. They did eat cheese daily as well as considerably more white bread as their main bread source.
I do drink milk but not every day. Especially with chocolate cake or other cake. I don't really care for cake and need milk to wash it down.
Ora
Juhana Harju - 24 Jun 2005 08:04 GMT :: On Fri, 24 Jun 2005 09:40:48 +0300, "Juhana Harju" :: <shantigiri@despammed.com> wrote: [quoted text clipped - 24 lines] :::::::: protected against insulin resistance and the metabolic :::::::: syndrome. [...] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15910636&query_hl=3
:::::: The free full study is available here: :::::: [quoted text clipped - 19 lines] :: The non-milk drinkers used more calcium supplementation than the :: milk drinkers. Only 1.7% used supplementation - so the supplementation was almost non-existent.
:: They did eat cheese daily Only 9.6% ate cheese daily.
:: as well as considerably :: more white bread as their main bread source. I noticed that too. Strange.
:: I do drink milk but not every day. Especially with chocolate cake :: or other cake. I don't really care for cake and need milk to wash :: it down. Milk hinders the absorption of cocoa flavonoids. Not a great idea to drink milk with chocolate from the nutritional point of view.
 Signature Juhana
nospam@aol.com - 24 Jun 2005 08:31 GMT >:: On Fri, 24 Jun 2005 09:40:48 +0300, "Juhana Harju" >:: <shantigiri@despammed.com> wrote: [quoted text clipped - 69 lines] >Milk hinders the absorption of cocoa flavonoids. Not a great idea to drink >milk with chocolate from the nutritional point of view. Perhaps that is why chocolate seems to have no effect on me although some people really get a lift from it. However thinking back, I used to get severe headaches when I was hungry - probably a bit of hypoglycemia and the only thing that zapped my headache was a lot of chocolate. I used to keep a box of Baker's semi-sweet chocolate in the kitchen and would eat some when I got a headache.
Ora
Juhana Harju - 24 Jun 2005 08:59 GMT :: On Fri, 24 Jun 2005 10:04:23 +0300, "Juhana Harju" wrote: ::: nospam@aol.com wrote:
::::: I do drink milk but not every day. Especially with chocolate cake ::::: or other cake. I don't really care for cake and need milk to wash [quoted text clipped - 9 lines] :: chocolate. I used to keep a box of Baker's semi-sweet chocolate in :: the kitchen and would eat some when I got a headache. I use coffee for the same purpose. Normally I don't drink almost any coffee, so I use it as a remedy for headaches.
 Signature Juhana
Rene - 27 Jun 2005 02:36 GMT > :: On Fri, 24 Jun 2005 10:04:23 +0300, "Juhana Harju" wrote: > ::: nospam@aol.com wrote: [quoted text clipped - 12 lines] > :: chocolate. I used to keep a box of Baker's semi-sweet chocolate in > :: the kitchen and would eat some when I got a headache. Dark chocolate contains magnesium. I take magnesium for my headaches. You may be craving chocolate because you are deficient in magnesium, which brings on the headache. http://www.amazon.com/exec/obidos/tg/detail/-/0345445880/104-7106978-7055969?v=glance
> I use coffee for the same purpose. Normally I don't drink almost any > coffee, > so I use it as a remedy for headaches. My ophthalmologist told me caffeine can give you a headache but also can sometimes counteract a headache that has been brought on from depriving yourself of your normal amount of caffeine. I can also drink a Starbucks for my headaches but would rather stick with magnesium.
René
nospam@aol.com - 27 Jun 2005 03:22 GMT >> :: On Fri, 24 Jun 2005 10:04:23 +0300, "Juhana Harju" wrote: >> ::: nospam@aol.com wrote: [quoted text clipped - 16 lines] >may be craving chocolate because you are deficient in magnesium, which >brings on the headache. I don't crave chocolate. I don't even care for it much. I found out quite by accident that it stops my hunger headaches although I haven't had one for years. I don't let myself get hungry any more.
Caffeine withdrawal headaches go away with a cup or two of coffee but hunger headaches stay around for a long time along with hunger pangs which stay even after eating.
Ora
>My ophthalmologist told me caffeine can give you a headache but also can >sometimes counteract a headache that has been brought on from depriving >yourself of your normal amount of caffeine. I can also drink a Starbucks >for my headaches but would rather stick with magnesium. > >René Rene - 28 Jun 2005 00:23 GMT >>> :: On Fri, 24 Jun 2005 10:04:23 +0300, "Juhana Harju" wrote: >>> ::: nospam@aol.com wrote: [quoted text clipped - 31 lines] > > Ora I used to get migraine headaches every month at the time of my menses. If I took magnesium early on, right when I felt the first little bit of nausea (with me, the nausea comes first), it sometimes curtailed it completely or toned it down enough so I could still function. I haven't had one for approx. 3 months since switching magnesium brands.
René
Juhana Harju - 24 Jun 2005 08:14 GMT :: On Fri, 24 Jun 2005 09:40:48 +0300, "Juhana Harju" :: <shantigiri@despammed.com> wrote: [quoted text clipped - 24 lines] :::::::: protected against insulin resistance and the metabolic :::::::: syndrome. [...] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15910636&query_hl=3
:::::: The free full study is available here: :::::: [quoted text clipped - 7 lines] ::::: Ever had wrist or hip fracture (%) 13.6 (12.6, 14.8) 21.1 (14.5, ::::: 29.7) 0.02 The hihger risk of osteoporosis and hip fractures can be partly explained by higher amount of smokers among the non-milk drinkers (10.9% vs. 16%).
BMJ. 1997 Oct 4;315(7112):841-6.
A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect.
Law MR, Hackshaw AK.
Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew's, London.
OBJECTIVE: To determine the magnitude and importance of the relation between smoking, bone mineral density, and risk of hip fracture according to age. DESIGN: Meta-analysis of 29 published cross sectional studies reporting the difference in bone density in 2156 smokers and 9705 non-smokers according to age, and of 19 cohort and case-control studies recording 3889 hip fractures reporting risk in smokers relative to non-smokers. RESULTS: In premenopausal women bone density was similar in smokers and non-smokers. Postmenopausal bone loss was greater in current smokers than non-smokers, bone density diminishing by about an additional 2% for every 10 year increase in age, with a difference of 6% at age 80. In current smokers relative to non-smokers the risk of hip fracture was similar at age 50 but greater thereafter by an estimated 17% at age 60, 41% at 70, 71% at 80, and 108% at 90. These estimates of relative risk by age, derived directly from a regression analysis of the studies of smoking and hip fracture, were close to estimates using the difference in bone density between smokers and non-smokers and the association between bone density and risk of hip fracture. The estimated cumulative risk of hip fracture in women in England was 19% in smokers and 12% in non-smokers to age 85; 37% and 22% to age 90. Among all women, one hip fracture in eight is attributable to smoking. Limited data in men suggest a similar proportionate effect of smoking as in women. The association was not explained by smokers being thinner, younger at menopause, and exercising less nor by actions of smoking on oestrogen, but smoking may have a direct action on bone. CONCLUSIONS: Hip fracture in old age is a major adverse effect of smoking after the menopause. The cumulative excess bone loss over decades is substantial, increasing the lifetime risk of hip fracture by about half. PMID: 9353503
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=9353503&query_hl=7
 Signature Juhana
nospam@aol.com - 24 Jun 2005 08:39 GMT >:: On Fri, 24 Jun 2005 09:40:48 +0300, "Juhana Harju" >:: <shantigiri@despammed.com> wrote: [quoted text clipped - 80 lines] > >http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=9353503&query_hl=7 Maybe if smokers drank more milk the results would be different. I am a smoker but I never smoke after drinking milk because milk makes me thirsty and smoking while thirsty just doesn't work for me.
Ora
Juhana Harju - 24 Jun 2005 09:03 GMT :: On Fri, 24 Jun 2005 10:14:21 +0300, "Juhana Harju" :: <shantigiri@despammed.com> wrote: [quoted text clipped - 26 lines] ::::::::::: who do not drink milk may be protected against insulin ::::::::::: resistance and the metabolic syndrome. [...] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15910636&query_hl=3
::::::::: The free full study is available here: http://www.epi.bris.ac.uk/staff/gdaveysmith/pdf/P485%20Avoiding.pdf
:::::::: Very interesting study. I noticed that those who did not drink :::::::: milk had considerably higher prevalence of hip fractures. [quoted text clipped - 49 lines] ::: decades is substantial, increasing the lifetime risk of hip ::: fracture by about half. PMID: 9353503 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=9353503&query_hl=7
:: Maybe if smokers drank more milk the results would be different. I :: am a smoker but I never smoke after drinking milk because milk makes :: me thirsty and smoking while thirsty just doesn't work for me. There are tiny capillaries in bones and smoking impedes circulation in these capillaries. I guess this is the main reason for higher osteoporosis and fractures in smokers.
 Signature Juhana
Enrico C - 24 Jun 2005 10:19 GMT > The hihger risk of osteoporosis and hip fractures can be partly explained by > higher amount of smokers among the non-milk drinkers (10.9% vs. 16%). Is there a reason why smokers drink milk, or milk drinkers smoke?
 Signature Enrico C
Juhana Harju - 24 Jun 2005 10:42 GMT :: On Fri, 24 Jun 2005 10:14:21 +0300, Juhana Harju wrote: :: [quoted text clipped - 3 lines] :: :: Is there a reason why smokers drink milk, or milk drinkers smoke? Smoking is more prevalent in people who have such an ethnic background which is associated with more lactose intolerance and lower drinking of milk? Smoking is more prevalent in the black population which has more osteoporosis in Britain due to lower vitamin D status? These are just guesses.
 Signature Juhana
Enrico C - 24 Jun 2005 13:03 GMT >:: On Fri, 24 Jun 2005 10:14:21 +0300, Juhana Harju wrote: >:: [quoted text clipped - 3 lines] >:: >:: Is there a reason why smokers drink milk, or milk drinkers smoke? Here I meant the other way round. Is there a reason why *non*-smokers drink milk, or milk drinkers *don't* smoke, or smokers *don't* drink milk...? Anyway, is there a relation between non-milk drinking and cigarette smoking?
> Smoking is more prevalent in people who have such an ethnic background which > is associated with more lactose intolerance and lower drinking of milk? > Smoking is more prevalent in the black population which has more > osteoporosis in Britain due to lower vitamin D status? These are just > guesses. Or might it be just random? :)
 Signature Enrico C
Juhana Harju - 24 Jun 2005 13:39 GMT :: On Fri, 24 Jun 2005 12:42:54 +0300, Juhana Harju wrote in :: <news:3i22ssFjfnujU1@individual.net> on sci.med.nutrition : [quoted text clipped - 12 lines] :: Anyway, is there a relation between non-milk drinking and cigarette :: smoking? I got it, but I don't know. I have a hunch that those people who smoke are more likely to drink coffee, alcoholic beverages etc. Perhaps they drink these beverages instead of milk.
::: Smoking is more prevalent in people who have such an ethnic ::: background which is associated with more lactose intolerance and [quoted text clipped - 3 lines] :: :: Or might it be just random? :) The sample is so large that it is not very likely. The correlation between non-milk drinking and higher prevalence in smoking is almost statistically significant (0.10). One can clearly make a conclusion that it is can be dangerous for health to stop drinking milk because it increases the probability of smoking. :-)
 Signature Juhana
Enrico C - 24 Jun 2005 12:53 GMT >> The hihger risk of osteoporosis and hip fractures can be partly explained by >> higher amount of smokers among the non-milk drinkers (10.9% vs. 16%). > > Is there a reason why smokers drink milk, or milk drinkers smoke? Sorry, I meant the other way round, of course. "Is there a reason why *non*-smokers drink milk, or milk drinkers *don't* smoke? Anyway, is there a relation between non-milk drinking and cigarette smoking?
 Signature Enrico C
Berna Bleeker - 24 Jun 2005 18:27 GMT Enrico C schreef:
> "Is there a reason why *non*-smokers drink milk, or milk drinkers *don't* > smoke? > Anyway, is there a relation between non-milk drinking and cigarette > smoking? Of course. Drinking milk is healthy, if you aren't allergic to it, and smoking is bad for your health. So people who aren't very health-conscious are more likely to smoke and to not drink milk.
Berna
 Signature ( )_( ) Berna M. Bleeker-Slikker / . . \ berna.bleeker@gmail.com \ \@/ / http://www.volksliedjes.nl
nospam@aol.com - 24 Jun 2005 18:52 GMT It could be that milk drinkers have more mouth lubrication and are less inclined to smoke because of that. After eating dairy products I have no inclination to smoke because it leaves me a bit thirsty.
Ora
>>> The hihger risk of osteoporosis and hip fractures can be partly explained by >>> higher amount of smokers among the non-milk drinkers (10.9% vs. 16%). [quoted text clipped - 6 lines] >Anyway, is there a relation between non-milk drinking and cigarette >smoking? Enrico C - 24 Jun 2005 12:53 GMT > The hihger risk of osteoporosis and hip fractures can be partly explained by > higher amount of smokers among the non-milk drinkers (10.9% vs. 16%). Is there a reason why *non*-smokers drink milk, or milk drinkers *don't* smoke? Anyway, is there a relation between non-milk drinking and cigarette smoking?
 Signature Enrico C
Enrico C - 24 Jun 2005 10:36 GMT >> [32 quoted lines suppressed] > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15910636&query_hl=3 [quoted text clipped - 3 lines] > > http://www.epi.bris.ac.uk/staff/gdaveysmith/pdf/P485%20Avoiding.pdf Three questions:
1. What do English milk drinkers usually have it with?
2. Might malabsorption of lactose explain the difference?
"Our results are consistent with a previous study that found individuals with malabsorption of lactose had lower fasting glucose levels and were less dyslipidaemic than normal absorbers (5)"
[...]
"Further studies are required to replicate our findings and to assess whether genetic variants associated with lactose intolerance are associated with insulin resistance and the metabolic syndrome [16]."
3. Aren't the results of this study in contrast with results from other studies recalled in the full text?
"Although imprecise when we stratified our analyse, we found that in both those who were overweight and those who were normal weight, not drinking milk was associated with reduced odds of the metabolic syndrome. In a study of men of Japanese ancestry living in Hawaii aged 45–68 years, there was no association between dietary calcium from dairy products and serum glucose or total cholesterol [11]. However, calcium may not be the constituent of milk that is related to metabolic abnormalities. In a study of French individuals aged 30– 64 years, the prevalence of the metabolic syndrome was lower in men who consumed greater than one portion of dairy products per day than those consuming less, with no association between consumption of dairy products and the metabolic syndrome in women [12]. No separate results for milk alone were given. This means that any effect of lactose is difficult to assess as cultured dairy products such as cheese and yogurt contain very little lactose [13]. A recent review concluded that epidemiological evidence for associations between milk consumption and insulin resistance, the metabolic syndrome or diabetes was scare and contradictory [14]. Milk may be associated with the metabolic syndrome because of its fat content. However, full-fat milk is only 4% fat and our associations remained with adjustment for other dietary factors, which will contribute much more too total fat consumption."
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