Resveratrol problem

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gehayw@hotmail.com - 25 Dec 2004 03:55 GMT

The anti-aging food chemical resveratrol is said to have an anti-cancer
effect by means of conversion to piceatannol. This conversion requires
the action of the cytochrome P450 enzyme CYP1B1. Piperine (bioperine)
is used to increase absorption of curcumin and other supplements and
inhibits P450 enzymes (generally speaking). Would piperine therefore
"neutralize" the anti-cancer effect of resveratrol? Any thoughts on
this?

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Larry Hoover - 25 Dec 2004 23:41 GMT

> The anti-aging food chemical resveratrol is said to have an anti-cancer
> effect by means of conversion to . This conversion requires
[quoted text clipped - 3 lines]
> "neutralize" the anti-cancer effect of resveratrol? Any thoughts on
> this?

I think the generalized statement that piperine inhibits P450 enzymes is overly
broad. I can find evidence in the literature that piperine inhibits CYP3A family
enzymes, as well as 2B1, but not of a more general activity.

I don't see anything that would support the idea that piperine would inhibit
resveratrol conversion to piceatannol. That conversion seems to be possible with
functional 1B or 1A.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=15276085

If it's a concern, you could alternate supplements on a daily basis.

Lar

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