Do you have any evidence to suspect that a diet based on generous consumption of
vegetables, fruit and fish would result in weight gain?

Your 2PD approach does not offer the same cardiovascular disease preventing
properties as the Polymeal diet. Second, your 2PD approach also entices people
to eat very energy dense foods, which is contrary to what is healthy. A healthy
approach is to favour nutrient dense foods, like vegetables and fruits, instead
of energy dense foods. The latter contain very little nutrients per calories.

I don't think so. :-)

Are you able to notice and appreciate when other people are doing good job -
like the researches in the study above?

Kim you asked about my "diet":

No diet. I should not have used that word. When I look at what I eat
and look at the various nutrition recommendations I seem to be between
the Polymeal and the Mediterranean: lots of fresh fruits and
vegetables, especially brightly coloured vegetables and green leafy
vegetables; whole grains; fish about four times a week, chicken or
turkey a couple times a week, red meat rarely--bison, moose, deer or
goat; something from the beans, pulses, and dal family every day, olive
oil, olives, walnut oil, various nuts and seeds including almond,
Brazil and walnuts; ground flax seed every day, a small amount of dairy
and cheese.

Up to one ounce Swiss, German, Belgian or Dutch dark chocolate or one
ounce cocoa powder (not hot chocolate mix) usually every day.

None to minimum trans fats. I know there was some trans fat in the two
Scottish oatcakes I ate today but I haven't had them for about a year.
Rarely purchased baked goods, and no baked goods unless made with whole
grains, canola or olive oil; or rarely, butter. (Hard to make
shortbread without butter.)

Several times a week a cup of either green tea, black tea with milk or
lemon or mint tea.

A good nutrition site to consult.

http://www.hsph.harvard.edu/nutritionsource/

The Polymeal diet is the subject of the thread we were in. Ed Mathes
gives a link.

Probably some things I left out. Here is what I ate today to give you
an idea:

Breakfast

4 ounces cooked Scottish oatmeal
1/2 ounce walnuts
1/2 ounce ground flax seed
1 1/2 ounces plain full fat yogurt
2 ounces sliced banana

4 ounces whole milk in 2 cups coffee (think I have to cut that down to
2 ounces and one cup).

Lunch

2 ounces medium gouda cheese
3 ounces (12 large) dark red grapes
2 Scottish oat cakes

Supper

2 ounces rice stick noodles
1/4 cup chicken broth
2 cups assorted julienned vegs: Anaheim green pepper, jalepeno pepper,
green beans, broccoli stem
1 small tomato
4 cloves garlic slivered
1 piece ginger thinly sliced
4 ounces snapper (fish)
2 green onions
teaspoon dark sesame oil
juice of one small lime
water to cook

one ounce dark chocolate (Droste pastilles)

2 litres water apart from water in cooking and coffee.
I usually eat an apple every day. Missed today.

Zee

"The Polymeal includes wine, fish, dark chocolate, fruits and vegetables,
almonds and garlic, eaten on a daily basis (but four times a week for fish).
Scientists reviewed the medical literature on how much each ingredient cuts
heart disease, blood pressure or cholesterol levels by varying amounts,
(150ml wine daily for instance reduces heart disease by 32%) and worked out
the combined effect of the ingredients. They then calculated the potential
effect across an ongoing study of American adults."

http://www.medicalnewstoday.com/medicalnews.php?newsid=17949

Of note, a recent article in Urology reveals that a man drinking 3 glasses
of red wine a week can reduce the risk of prostate cancer by aboout 40%.

Ed

..............

Something to investigate.

Grapefruit Juice and Medications: A Potential for Adverse Events

Many patients may take their medications with a glass of juice. However,
since the accidental discovery of an interaction between the calcium
channel blocker, felodipine, with grapefruit juice,1 it has now become
evident that grapefruit juice has the potential to

alter the plasma concentrations of many medications when they are taken
by mouth. In some cases, this may result in undesirable clinical effects
of medications.

Administration of grapefruit juice in humans results in a decrease in
the level of CYP3A in the intestine,2 an important site for metabolism
for many medications. This mechanism would account for the increase in
levels of medications that are metabolized by CYP3A when concomitantly
administered with grapefruit juice.

A list of medications that have been shown, in clinical studies, to have
an interaction with grapefruit juice can be found in the table below.
All of the medications, except for theophylline and itraconazole, are
known to be substrates of CYP3A. When given with grapefruit juice in
pharmacokinetic studies their availability increases. In most cases, the
clinical consequence of the pharmacokinetic interaction has not been
evaluated. However, for midazolam and triazolam, as well as for
buspirone, impairment of CNS function was observed, and for the calcium
channel blocker felodipine greater blood pressure lowering has been
observed. In contrast to the increased levels of the other medications,
the grapefruit juice interaction observed with theophylline and
itraconazole was reduced plasma concentrations. The mechanism for this
effect has not been determined.

Although the clinical consequence of the grapefruit juice interaction
with most of the listed drugs has not been evaluated, increased plasma
concentrations of many of these drugs could result in adverse outcomes.
Examples include excessive lowering of blood pressure with the calcium
channel blockers, rhabdomyolysis and the potential for renal impairment
with the HMG CoA reductase inhibitors, and adverse pulmonary effects of
amiodarone. Inconsistent use of grapefruit juice or variability in its
effect on drug metabolism could result in variable and difficult to
control plasma concentrations of other medications, where maintaining a
certain plasma concentration may be especially important, such as for
cyclosporine or for HIV protease inhibitors like saquinavir.

In light of the potential for serious adverse outcomes, patients taking
medications with a potential for interaction with grapefruit juice
should be advised to avoid drinking grapefruit juice. Possible
interactions with whole grapefruit have not been evaluated but it would
be assumed to have similar effects.

Drug Class (Therapeutic Uses)

Medication

Brand Names

Antidepressant (depression)
Sertraline  
Zoloft

Antihypertensive (high blood pressure)
Felodipine  
Plendil

Nisoldipine  
Sular

Pranidipine  
Not available in the United States

Antilipemic (lowers cholesterol)
Atorvastatin  

Lipitor

Lovastatin  
Mevacor

Simvastatin  

Zocor

Antimalarial (malaria infection)

Artemether

Paluther

Antiretroviral (HIV infection)
Saquinavir

Fortovase, Invirase

Anxiolytic (anxiety); Sedative (sleep)
Diazepam  

Valium

Midazolam

Versed

Triazolam

Halcion

Buspirone  

BuSpar

Bronchodilator (asthma, bronchospam)
Theophylline  
Theo-Dur, Slo-bid, others

GI stimulant (stimulates GI motility)
Cisapride

Propulsid

Estrogen (birth control, hormone replacement therapy)
Ethinyl estradiol  

Ortho-Novum, Loestrin, femhrt, others

Immune suppressant (prevents organ rejection)
Cyclosporine
Neoral, Sandimmune, SangCya

Antifungal (fungal infection)
Itraconazole

Sporanox

Antiarryhthmic (heart rhythm)
Amiodarone  
Cordarone, Pacerone

Note: Medication names are hyperlinked to references in PubMed

1.                    Bailey DG, Spence JD, Munoz C, Arnold JMO.  
Interaction of citrus juices with felodipine and nifedipine.  Lancet
1991; 337:268-9.

2.                    Lown KS, Bailey DG, Fontana RJ, et al.  
Grapefruit juice increases felodipine oral availability in humans by
decreasing intestinal CYP3A protein expression.

Return to Drug Interaction Advisory Index



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It is GRAPES and GRAPE JUICE, not grapefruit or grapefruit juice, to
substitute for wine. What a nice man!

Dear Zee

I apologize for the confusion that in a mistake from my not so good
english I have generated. When I said grapefruit I was refering to
"UVAS"
which are grapes. I had not idea that grapes and grapefruits were
different. I am not a native english speaker, my mother tongue is
spanish!
I was refering to grape juice (similar to wine which comes also from
grapes but without alcohol). About grapefruit, I can not tell much
about
its interactions with medicaments, I am still not sure what it exactly
is,
my wife is here explaining me that it is a sort of orange and tastes
like
lemon. I am sorry for the confusion, please take my apologies and offer
them in my name to the members of your discussion group. I will love to
join your discussion group but here in the Netherlands is saturday
23+17,
its time to sleep! Greetings and thank you once more for your interest!
Dr Oscar H. Franco