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chelation of iron prevented the hyperactivity
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Behav Brain Res. 2004 Oct 5;154(2):321-9. Related Articles, Links  

 
Stress-induced behaviour in juvenile rats: effects of neonatal asphyxia, body
temperature and chelation of iron.

Rogalska J, Caputa M, Wentowska K, Nowakowska A.

Department of Animal Physiology, Institute of General and Molecular Biology, N.
Copernicus University, ul. Gagarina 9, 87-100 Torun, Poland.
rogal@biol.uni.torun.pl

Newborn mammals, showing reduced normal body temperature, might be protected
against iron-mediated, delayed neurotoxicity of perinatal asphyxia. Therefore,
we investigated the effects of (1) neonatal body temperature and neonatal
critical anoxia as well as (2) postanoxic chelation of iron with deferoxamine,
on open-field stress-induced behaviour in juvenile rats. The third aim of this
study was to compare (after the above-mentioned treatments) circadian changes
in spontaneous motor activity and body temperature in juvenile rats permanently
protected from any stress. Neonatal anoxia at body temperature adjusted (both
during anoxia and 2 h reoxygenation) to a level typical of healthy (37 degrees
C) or febrile (39 degrees C) adults led to the stress-induced hyperactivity in
juvenile (5-45 days old) rats. Both normal neonatal body temperature of 33
degrees C and chelation of iron prevented the hyperactivity in rats. Neither
neonatal body temperature nor neonatal anoxia affected spontaneous motor
activity or body temperature of juvenile rats, recorded in their home-cages
with implantable transmitters. Circadian rhythmicity was also undisturbed.
Presented data support the hypothesis that physiologically reduced neonatal
body temperature can provide a protection against iron-mediated postanoxic
disturbances of behavioural stress responses in juvenile rats.

PMID: 15313019 [PubMed - indexed for MEDLINE]

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