>Dig Dis Sci. 2004 Sep;49(9):1433-7. Related Articles, Links
>
>Decreased total and corrected antioxidant capacity in patients with
>inflammatory bowel disease.
>
>Koutroubakis IE, Malliaraki N, Dimoulios PD, Karmiris K, Castanas E,
>Kouroumalis EA.
>
>Department of Gastroenterology, University Hospital Heraklion, P.O. Box 1352,
>Heraklion 71110, Greece. ktjohn@her.forthnet.gr
>
>Oxidative stress and depletion of antioxidants may play a key role in the
>pathogenesis of inflammatory bowel disease (IBD)-related intestinal damage. A
>new automated assay for the determination of blood total antioxidant capacity
>(TAC), based on the crocin bleaching method, has been used for the measurement
>of TAC and corrected TAC (cTAC) in patients with ulcerative colitis (UC) and
>Crohn's disease (CD) in comparison to healthy controls (HC). Ninety-four
>patients with UC, 97 patients with CD, and 72 HC were included in this study.
>Serum TAC was measured in all patients and controls on an Olympus AU-600
>chemistry analyzer using a TAC kit. cTAC was calculated from TAC after
>subtraction of the interactions due to endogenous uric acid, bilirubin and
>albumin. Mean serum TAC as well as cTAC levels were significantly lower in both
>UC and CD patients compared with HC (P < 0.0001). Patients with active UC had
>no different TAC and cTAC compared to those with inactive disease. Patients
>with active CD had significantly lower mean TAC compared to those with inactive
>disease but cTAC was not different between the two phases of disease activity.
>Patients with proctitis had significantly higher TAC and cTAC compared to
>patients with left-sided colitis and total colitis. In CD patients no
>association between disease localization and these markers was found. TAC and
>cTAC are significantly reduced in IBD patients compared with controls
>irrespective of disease activity. The decreased antioxidant defenses may be a
>primary phenomenon severely compromising the mucosa and therefore increase
>susceptibility to oxidative tissue damage.
>
>PMID: 15481315 [PubMed - in process]
>
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