<<snip>>
iron deposition resulting from hemochromatosis leads to Nephrogenic diabetes
insipidus
<<snip>>

Am J Kidney Dis. 2002 Aug;40(2):403-6.  Related Articles, Links  

 
Nephrogenic diabetes insipidus associated with hemochromatosis.

Okumura A, Kondo K, Hirai C, Nishimura H, Tamai H, Kawarazaki F, Ichikawa M,
Mizuno M, Oiso Y, Yamamoto M.

Department of Endocrinology and Metabolism, Anjo Kosei Hospital, Anjo, Japan.
okumura@kosei.anjo.aichi.jp

Although hemochromatosis is one of the most common genetic disorders in humans,
the clinical information on iron-induced renal impairment is limited. We
describe the clinical features of nephrogenic diabetes insipidus (NDI) observed
in a case of hemochromatosis. A 57-year-old diabetic man was admitted to the
hospital with a 6-month history of persistent polyuria, which had been
sustained after glycemic optimization with insulin therapy and resulted in
hepatic coma. Despite sufficient basal excretion of arginine vasopressin,
impaired urinary concentrating capacity was observed, which could not be
corrected by supraphysiologic doses of exogenous arginine vasopressin.
Histochemical investigations showed widely distributed iron deposition in
hepatocytes and moderately increased iron deposits in the tubular epithelium of
distal urinary tubules and collecting ducts, suggesting that iron deposition
resulting from hemochromatosis leads to NDI. This may be the first case report
of NDI associated with hemochromatosis in humans. More attention should be paid
to latent NDI as another complication of hemochromatosis. Copyright 2002 by the
National Kidney Foundation, Inc.

Publication Types:
Case Reports

PMID: 12148115 [PubMed - indexed for MEDLINE]

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