Medical Forum / General / Nutrition / September 2004
Mediterranean diet increases life span
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markd@toad-net.com - 22 Sep 2004 14:37 GMT Here is another news article how this diet increases by 50 percent life span in the elderly:
http://www.eurekalert.org/pub_releases/2004-09/jaaj-mda091604.php
Mirek Fidler - 22 Sep 2004 15:39 GMT Only problem now is to decide what is mediterranean diet... :)
Mirek
Matti Narkia - 22 Sep 2004 16:42 GMT Wed, 22 Sep 2004 16:39:35 +0200 in article <2rdgocF18gmgtU1@uni-berlin.de>
>Only problem now is to decide what is mediterranean diet... :) Not really. Many studies have developed a scoring system for measuring the adherence to the Mediterranean diet. The details of the diet varies among different Mediaterranean countries, but there are certain common factors. The traditional diet of Crete is regarded as healthiest of all variations of Mediterranean diets and therefore should perhaps be used as a general guideline.
See for example
Pitsavos C, Panagiotakos DB, Chrysohoou C, Papaioannou I, Papadimitriou L, Tousoulis D, Stefanadis C, Toutouzas P. The Adoption of Mediterranean Diet Attenuates the Development of Acute Coronary Syndromes in People with the Metabolic Syndrome. Nutr J. 2003 Mar 19;2(1):1. PMID: 12740043 [PubMed - as supplied by publisher] <http://www.nutritionj.com/content/2/1/1>
An excerpt summarizinging the common features of Mediterranean diets:
"... The Mediterranean dietary pattern consists of: (a) daily consumption: of non refined cereals and products (whole grain bread, pasta, brown rice, etc), vegetables (2 3 servings/day), fruits (6 servings/day), olive oil (as the main added lipid) and dairy products (1 2 servings/day), (b) weekly consumption: of fish (45 servings/week), poultry (3 4 servings/week), olives, pulses, and nuts (3 servings/week), potatoes, eggs and sweets (3 4 servings/week) and monthly consumption: of red meat and meat products (4 5 servings/month). It is, also, characterized by moderate consumption of wine (1 2 wineglasses/day) and high monounsaturated: saturated fat ratio (> 2). This dietary pyramid was suggested by a Harvard-led group with substantial input from Greek scientists [13]. ..."
Evidence-based nutrition Dimitrios TrichopoulosMD, Pagona Lagiou, and Antonia TrichopoulouMD Asia Pacific Journal of Clinical Nutrition Volume 9 Issue Suppl. Page S4 - October 2000 doi:10.1046/j.1440-6047.2000.00174.x>Vol. 9 Issue Suppl. <URL:http://www.blackwell-synergy.com/links/doi/10.1046/j.1440-6047.2000.00174.x/full/>
"Overall, the traditional Mediterranean diet may be thought of as having eight components: (i) a high monounsaturated to saturated fat ratio; (ii) moderate ethanol consumption; (iii) high consumption of legumes; (iv) high consumption of cereals (including bread); (v) high consumption of fruits; (vi) high consumption of vegetables; (vii) low consumption of meat and meat products; and (viii) moderate consumption of milk and dairy products."
[...]
Three studies have recently been published evaluating the role of the Mediterranean diet as operationally defined through the eight components discussed previously. The first of these studies was conducted in Greece, 2 the second in Denmark 33 and the third in Australia. 34 All have shown that the Mediterranean diet has beneficial, substantial and statistically significant effects on longevity."
Traditional Mediterranean (Greek & S.Italy) & Asian (Japan) Food Patterns of the 1960's. <URL:http://www.healthyeatingclub.com/info/articles/foodcult/mediterr-asia.htm>
"The Cretan diet was one of the highest fat diets in the study (40% energy as fat, but low in saturated fat and high in monounsaturated fat), but the Cretan Greeks eating it came out with some of the lowest rates of CHD and all-cause mortality and consequently had the longest life expectancies in the world at that time. They were even living longer than mainland Greeks and the Japanese.
[...] The Cretan diet was also relatively low in carbohydrates (45% energy) with most of the carbohydrates consumed being of low glycaemic index. Even though the diet was high in fat, it paradoxically had a low energy density because of the large volume of plant foods consumed. The Cretan diet in the 1960's consisted of a high intake of vegetables (360g/day i.e. 2-3 cups/day), especially green leafy types, high intakes of legumes (30g/day), nuts (30g/day), fruit (460g/day i.e. 2-3 fruits /day) and wholegrain cereals (450g/day i.e. 8 slices of bread/day). Vegetables were used as an integral part of meals, not served on the side. Breads were made by allowing dough to ferment slowly, resulting in a lower glycaemic index. In contrast, many breads we eat today use the rapid dough fermentation procedure resulting in breads with a higher glycaemic index. They also had moderate intakes of fish (40g/day), alcohol (20g/day, with meals i.e. 2 standard drinks/day) and low intakes of red/white meat (35g/day) and fermented sheep/goats milk products (cheese/yoghurt consumed weekly). Unfermented dairy products i.e. fresh sheep/goats milk was reserved for children. The average daily intakes of some of these foods converted to the real-life situation of weekly consumption, would be: a 200g serving of fish twice a week, a 200g serving of chicken/pork once a week, a serving of lamb once a week or less, and bean/lentil soups or casseroles about 2-3 times a week. The Cretan diet was also low in animal fats (butter/margarine rarely eaten) and saturated fat (8% energy), but high in total fat (40% energy) and monounsaturated fat (25% energy) because the major source of fat was olive oil (about 4 tablespoons/day), which was nearly always consumed as 'extra virgin' or the first pressing of the olive and nearly always consumed with plant food. It was also high in omega-3 linolenic acid (probably about 1% energy intake) due to the high intake of nuts (especially walnuts), wild greens (especially purslane) and legumes. Furthermore, animals (sheep, goats, pigs, chickens) were not always fed on grains (which is relatively rich in n-6 fats), but were also allowed to graze on wild plants and herbs, resulting in fat deposits which were higher in n-3 fats. So the little meat they ate tended to be leaner and the fat of these animals was higher in n-3 fats and probably phytochemicals.
The diet also had a favourable n-6: n-3 ratio (<5:1) due to the absence of polyunsaturated oils in the diet, the high intake of olive oil and foods high in n-3 fatty acids (including fish). In the 7 countries study, Cretan men had the lowest incidences of CHD and cancer, followed by Japan. Even though the fat content of the two diets was very different (40% vs. 10% total energy respectively) both were rich in omega-3 fatty acids (Simpoulos Prostaglandins, Leukotrienes & Ess Fatty Acids 1999; 60: 421-9). Cretan men were found to have 3-fold higher intakes of n-3 linolenic compared with the cohort from the Netherlands and 21% lower intakes of n-6 linoleic acid (Sandker et al. Eur J Clin Nutr 1993; 47: 201-8).
[...] Mediterranean diet and Survival in the Elderly in the 1990's. Further evidence in support of the Mediterranean food pattern of the 1960s has come from three prospective cohort studies which described the food habits of people aged 70 and over in Greece (Trichopoulou, Kouris-Blazos et al., BMJ 1995; 311 (7018): 1457-1460), Australia (Kouris-Blazos et al. Br J Nutr, 1999; 82: 57-61) and Denmark (Osler & Schroll, Int J Epidem 1997; 26 (1): 155-9). These cohorts were followed-up 5-6 years later to ascertain survival status. The Australian study included Greek-born and Anglo-Celtic born elderly living in Melbourne. Subjects with food patterns consistent with the food patterns found in Greece in the 1960s had a reduced risk of death by about 50%, even as late as 70 years and onwards. Smoking and male gender were not significant predictors of mortality. The food pattern was defined as follows:
1) high consumption of vegetables; 2) high consumption of legumes; 3) high consumption of fruits; 4) high consumption of cereals; 5) low consumption of dairy products; 6) low consumption of meat and meat products; 7) moderate ethanol consumption; 8) high monounsaturated: saturated fat ratio.
Subjects achieved greater mortality advantage if they followed the entire food pattern, suggesting synergy between food groups. To read the full text BMJ paper on the study in Greece go to: http://www.bmj.com/cgi/content/full/311/7018/1457
Close Adherence to a Traditional Mediterranean Diet Promotes Longevity Benefits of following the diet long-term appear to increase with age <URL:http://www.hsph.harvard.edu/press/releases/press06252003.html>
"The traditional Mediterranean diet features an abundance of vegetables, legumes, fruits, nuts and cereals and regular use of olive oil (monounsaturated fats), moderate amounts of fish and dairy products (mostly yogurt or cheese), small amounts of red meat (low intake of saturated fats) and moderate consumption of alcohol, usually in the form of wine and consumed at meals."
Mediterranean Diet: More Than Olive Oil 'Divine Mix' Prevents Death From Cancer, Heart Disease <URL:http://my.webmd.com/content/article/67/80070.htm>
"When the researchers looked at the individual components of the Mediterranean diet, they found no significant decrease in death with any one type of food.
In addition to having olive oil with most meals, the typical Mediterranean diet is very high in vegetables, fruits, legumes, nuts, and cereals; moderate in fish intake; and has lower amounts of meat and dairy than the typical American diet. Drinking alcohol is also a frequently practiced dining ritual.
"God knows what sorts of interactions take place within the foods, and we need further research to pinpoint them exactly," Trichopoulos tells WebMD.
"But typically, people in Greece eat twice as many vegetables as Americans -- nearly a pound a day. And you really can't eat a pound of vegetables a day unless you have olive oil to make them appetizing. My advice is to try to double the amount of vegetables and fruits you currently have, and eat more fish, legumes, and non-refined cereals."
While olive oil itself showed little benefit, the researchers note a significant reduction in death rates from a higher overall ratio of monounsaturated fats to saturated fats. Olive oil is among the best sources of monounsaturated fats -- and happens to be the main cooking oil in most Mediterranean countries -- but other oils frequently consumed by Greeks and others surrounding the Mediterranean Sea also contain these healthy fats. "
Simopoulos AP. The Mediterranean diets: What is so special about the diet of Greece? The scientific evidence. J Nutr. 2001 Nov;131(11 Suppl):3065S-73S. Review. PMID: 11694649 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1 1694649&dopt=Abstract>
The Mediterranean Diet Pyramid <URL:http://www.oldwayspt.org/pyramids/med/p_med.html> <URL:http://www.e-guana.net/organizations.php3?orgid=61&typeID=193&action=printConten tItem&itemID=1529> <URL:http://www.diet-i.com/mediterranean-diet-pyramid.htm>
Mediterranean Diet Guidelines <URL:http://www.diet-i.com/mediterranean-diet.htm>
Quantum - Mediterranean Diet Guidelines <URL:http://www.abc.net.au/quantum/stories/meddiet.htm>
Essential Elements of the Mediterranean Diet <URL:http://www.trincoll.edu/~jvillani/Ingredients.htm>
Cretan diet and food details. Diet and food of Crete island quality, benefits and cretan food producers <URL:http://greekproducts.com/greekproducts/cretan.html>
Crete | The Cretan Diet - Cretan cuisine & healthy food - by CreteTravel.com http://www.cretetravel.com/Cretan_Diet/Cretan_Diet_1.htm
The Mediterranean Diet <URL:http://www.cheshire-med.com/services/dietary/nutrinew/mediter.html>
The Mediterranean Diet and Mortality Olive Oil and Beyond <URL:http://www.medical-journals.com/r03266b.htm>
Postgraduate Medicine: Understanding the Mediterranean diet <URL:http://www.postgradmed.com/issues/2002/08_02/curtis.htm>
Hearty Diet <URL:http://www.accessexcellence.org/WN/SUA11/meddiet897.html>
Mediterranean Diets Francesco Visioli, Ph.D. Visiting Scientist <URL:http://lpi.oregonstate.edu/f-w00/mediterr.html>
 Signature Matti Narkia
Mirek Fidler - 22 Sep 2004 17:46 GMT > vegetables (2 - 3 servings/day), fruits (6 > servings/day), olive oil (as the main added lipid) and > dairy products (1 - 2 servings/day), And here problems arise - in the original article posted by markd, it is specifically noted that " low in meat and dairy products ".
Now here it is 1-2 servings of dairy / day. Not quite a low.
> "The Cretan diet was one of the highest fat diets in the study > (40% energy as fat, but low in saturated fat and high in Well, now we have high fat diet :)
> [...] > > The Cretan diet was also relatively low in carbohydrates (45% > energy) with most of the carbohydrates consumed being of low And low-carb. :)
> They also had moderate intakes of fish (40g/day), alcohol > (20g/day, with meals i.e. 2 standard drinks/day) and low > intakes of red/white meat (35g/day) and fermented sheep/goats > milk products (cheese/yoghurt consumed weekly). How it comes that previous list has 2 servings of dairy / day?
> 5) low consumption of dairy products; Now I am really confused :)
> of olive oil (monounsaturated fats), moderate amounts of fish > and dairy products (mostly yogurt or cheese), small amounts of And once again moderate....
That said, I going to prepare my dinner:
2 tomatoes, 1 cucumber, 2 pepperoni, olives, mediterranean type "wet" cheese and olive oil (quite a lot - I am on high fat diet in the end :). I call it "Greek salad" :)
Mirek
Matti Narkia - 22 Sep 2004 19:09 GMT Wed, 22 Sep 2004 18:46:09 +0200 in article <2rdo5mF19j57qU1@uni-berlin.de>
>> vegetables (2 - 3 servings/day), fruits (6 >> servings/day), olive oil (as the main added lipid) and [quoted text clipped - 4 lines] > >Now here it is 1-2 servings of dairy / day. Not quite a low. Meat consumptions is _very_ low in the traditional Cretan diet, perhaps only once month or so. The "general" Mediterranean diet pattern includes slightly more meat. Dairy product intake was low to moderate, lower in Crete than elsewhere. Only fermented dairy products (goat/sheep milk feta cheese and yoghurt) were used in Crete, and the Greek ortodox tradition advised to avoid even these every Wednesday and Friday throughout the year and during religious fast periods.
>> "The Cretan diet was one of the highest fat diets in the study >> (40% energy as fat, but low in saturated fat and high in > >Well, now we have high fat diet :) Nothing wrong with that if the fats are of right kind.
>> They also had moderate intakes of fish (40g/day), alcohol >> (20g/day, with meals i.e. 2 standard drinks/day) and low >> intakes of red/white meat (35g/day) and fermented sheep/goats >> milk products (cheese/yoghurt consumed weekly). > >How it comes that previous list has 2 servings of dairy / day? 1-2 servings. The first list described the general Mediterranean dietary pattern and this list the traditional Cretan diet, which includes less dairy products.
>> 5) low consumption of dairy products; > >Now I am really confused :) This describes food patterns found in Greece in the 1960s of which the traditional Cretan diet is the prime example. No reason to get confused, if you just read the whole texts and place the described pattern in the right context.
>> of olive oil (monounsaturated fats), moderate amounts of fish >> and dairy products (mostly yogurt or cheese), small amounts of > >And once again moderate.... This is Harvard's very brief and general summary of the traditional Mediterranean diet. The traditional Cretan diet is slightly stricter with dairy products.
To summarize, the traditional Cretan diet is slightly stricter with meat and dairy products than the "general" Mediterranean food pattern, which otherwise seems fairly consistently defined.
The Cretans also used a lot of local wild herbs.
>That said, I going to prepare my dinner: > >2 tomatoes, 1 cucumber, 2 pepperoni, olives, mediterranean type "wet" >cheese and olive oil (quite a lot - I am on high fat diet in the end :). >I call it "Greek salad" :) The "wet" cheese is feta cheese, preferably made of goat or sheep milk. It is indeed called Greek salad everywhere.
When traditional Cretan diet is described, often the effects of Greek orthodox fasting periods' effects are not discussed or even mentioned. Sarri et al [1,2] have recently researched the effects of these periods. They describe these fasts as follows [2]:
"Orthodox Christian holy books recommend a total of 180200 days of fasting per year. The faithful are advised to avoid olive oil, meat, fish, milk and dairy products every Wednesday and Friday throughout the year. Additionally, there are three principal fasting periods per year: i) a total of 40 days preceding Christmas (meat, dairy products and eggs are not allowed, while fish and olive oil are allowed except on Wednesdays and Fridays), ii) a period of 48 days preceding Easter (Lent). During Lent fish is allowed only two days whereas meat, dairy products and eggs are not allowed. Olive oil consumption is allowed only at weekends, iii) a total of 15 days in August (the Assumption) when the same dietary rules apply as for Lent with the exception of fish consumption which is allowed only on August 6th. Seafood such as shrimps, squid, cuttlefish, octopus, lobsters, crabs as well as snails are allowed on all fasting days throughout the year. The Greek Orthodox fasting practices can therefore be characterized as requiring a periodic vegetarian diet including fish and seafood.
The variant of vegetarianism followed during fasting periods by Orthodox Christians, with a diet of vegetables, legumes, nuts, fruits, olives, bread, snails and seafood, is a type of the so- called Mediterranean diet [15,16]. To date little is known as to the effects of this 'hidden' element of the traditional Orthodox Christian diet on health and no data exist on the effect of Orthodox Christianity's dietary rules on blood lipid levels and obesity. The objective of this study was therefore to assess the effects of intermittent short-term religious fasting, according to the dietary rules of the Orthodox Christian Church, on blood lipoprotein profile and the prevalence of obesity."
During the fasts LDL, BMI and intake of energy and calcium are statistically significantly reduced, and intake of fiber and folate are statistically significantly increased.
References:
1: Sarri KO, Linardakis MK, Bervanaki FN, Tzanakis NE, Kafatos AG. Greek Orthodox fasting rituals: a hidden characteristic of the Mediterranean diet of Crete. Br J Nutr. 2004 Aug;92(2):277-84. PMID: 15333159 [PubMed - in process] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra ct&list_uids=15333159>
2: Sarri KO, Tzanakis NE, Linardakis MK, Mamalakis GD, Kafatos AG. Effects of Greek Orthodox Christian Church fasting on serum lipids and obesity. BMC Public Health. 2003 May 16;3(1):16. PMID: 12753698 [PubMed - indexed for MEDLINE] <URL:http://www.biomedcentral.com/1471-2458/3/16> <URL:http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12753698>
 Signature Matti Narkia
Lictor - 22 Sep 2004 19:31 GMT > Wed, 22 Sep 2004 18:46:09 +0200 in article <2rdo5mF19j57qU1@uni-berlin.de> > The Cretans also used a lot of local wild herbs. And they also eat snails, which eat these herbs. These herbs have been tested as part of a margarine in a study in France on CHD and cholesterol. They have shown quite significant improvements in the lipid profiles. Interrestingly enough, the manufacturer of the margarine decline to market it, and preferred to push it's "high" omega-3 sunflower margarine instead... The problem when you study a diet like this is missing "tiny" details like these herbs. It would be like studying the American diet, and coming with the conclusion that it is good for cholesterol levels (it is, cholesterol levels are lower in the USA than in France). Of course, that study would have forgotten tiny facts, like an increasing number of Americans being on statins or other anti-cholesterol drugs, which are a rarity in France. The mediterrannean diet has an history of being distorted to match the point of view of the author. It used to be sold (in France) as a low fat diet for instance, which it certainly isn't.
>>That said, I going to prepare my dinner: >> [quoted text clipped - 4 lines] > The "wet" cheese is feta cheese, preferably made of goat or sheep milk. > It is indeed called Greek salad everywhere. Add some onion, some lemon juice and it's a great summer salad. :) Eat with some Italian ham, and you have a whole meal...
Matti Narkia - 22 Sep 2004 23:43 GMT Wed, 22 Sep 2004 20:31:51 +0200 in article <4151c518$0$7863$79c14f64@nan-newsreader-05.noos.net> Lictor <ghostmlNOSPAM@online.fr> wrote:
>> Wed, 22 Sep 2004 18:46:09 +0200 in article <2rdo5mF19j57qU1@uni-berlin.de> >> The Cretans also used a lot of local wild herbs. [quoted text clipped - 5 lines] >decline to market it, and preferred to push it's "high" omega-3 >sunflower margarine instead... Yep, in the Lyon Diet Heart Study. More about it in
Serge Renaud: from French paradox to Cretan miracle. Lancet 2000; 355: 48 - 52. <URL:http://www.thelancet.com/journal/vol355/iss9197/full/llan.355.9197.news.2419.1>
de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, Delaye J. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994 Jun 11;343(8911):1454-9. Erratum in: Lancet 1995 Mar 18;345(8951):738. PMID: 7911176 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7 911176&dopt=Abstract>
Renaud S, de Lorgeril M, Delaye J, Guidollet J, Jacquard F, Mamelle N, Martin JL, Monjaud I, Salen P, Toubol P. Cretan Mediterranean diet for prevention of coronary heart disease. Am J Clin Nutr. 1995 Jun;61(6 Suppl):1360S-1367S. PMID: 7754988 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7 754988&dopt=Abstract>
de Lorgeril M, Salen P, Martin J-L, Monjaud I, Delaye J, Mamelle N: Mediterranean diet, traditional risk factors and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation 1999, February 16, 99:779-785 <URL:http://circ.ahajournals.org/cgi/content/full/99/6/779>
Leaf A. Dietary prevention of coronary heart disease: the Lyon Diet Heart Study. Circulation. 1999 Feb 16;99(6):733-5. <URL:http://circ.ahajournals.org/cgi/content/full/99/6/733>
 Signature Matti Narkia
Mirek Fidler - 22 Sep 2004 19:40 GMT > Meat consumptions is _very_ low in the traditional Cretan diet, perhaps only > once month or so. The "general" Mediterranean diet pattern includes slightly [quoted text clipped - 3 lines] > avoid even these every Wednesday and Friday throughout the year and during > religious fast periods. Well, Matti, but that is why my original complaint about m. diet was that it is a little bit hard to determine exactly what m. diet is.
In any case, there are some important lessons that are probably correct:
a) a lot of veggies and fruits b) a lot of olive oil c) relatively low carbs and relatively high fat d) fish
> >Well, now we have high fat diet :) > > > Nothing wrong with that if the fats are of right kind. Yes!
> >> 5) low consumption of dairy products; > > [quoted text clipped - 4 lines] > you just read the whole texts and place the described pattern in the right > context. Well, I was making a bit of fun. What I wanted to point out that m. diet is VERY often used as buzzword to promote very different nutritional approaches. E.g. it is sometimes even described as low-fat, high carb diet, which seems to be absolute nonsense - even if it is true that mediterranean covers pretty big area with very different lifestyles, so that Italian diet is probably thousands light years different from Greece.
Anyway, it is true that above 4 points are shared, esp. compared to traditional USA diet.
> To summarize, the traditional Cretan diet is slightly stricter with meat and > dairy products than the "general" Mediterranean food pattern, which > otherwise seems fairly consistently defined. I am afraid it is not....
> >2 tomatoes, 1 cucumber, 2 pepperoni, olives, mediterranean type "wet" > >cheese and olive oil (quite a lot - I am on high fat diet in the end [quoted text clipped - 3 lines] > The "wet" cheese is feta cheese, preferably made of goat or sheep milk. > It is indeed called Greek salad everywhere. I know what real feta is, but I called my version "wet" m. type, because unfotunatly real feta is not easily available....
Anyway, our local (and not so expensive) version tastes very good too (when mixed with other ingredients).
> When traditional Cretan diet is described, often the effects of Greek > orthodox fasting periods' effects are not discussed or even mentioned. Sarri > et al [1,2] have recently researched the effects of these periods. They > describe these fasts as follows [2]: Very good point. One should also take into account general climate in the area. These things are often being forgotten by experts trying to explain everything by diet composiion.
> is allowed only on August 6th. Seafood such as shrimps, squid, > cuttlefish, octopus, lobsters, crabs as well as snails are > allowed on all fasting days throughout the year. Seems fish consumption might have been even higher than suggested...
> The Greek > Orthodox fasting practices can therefore be characterized as > requiring a periodic vegetarian diet including fish and > seafood. What nonsense is this? "Vegetarian diet including fish and seafood" ?!
> fruits, olives, bread, snails and seafood, is a type of the so- Snails ? :) Do they have the right kinds of fats? :)
Mirek
Matti Narkia - 22 Sep 2004 20:17 GMT Wed, 22 Sep 2004 20:40:29 +0200 in article <2rdus7F17rp3kU1@uni-berlin.de>
>> To summarize, the traditional Cretan diet is slightly stricter with meat and >> dairy products than the "general" Mediterranean food pattern, which >> otherwise seems fairly consistently defined.
>I am afraid it is not.... IMHO it is, at least in studies about Mediterranean diet. But these are usually based either on the traditional Greek Mediterranean diet or especially on the traditional Cretan Mediterranean diet.
Other public descriptions may vary. But even in them there is a pattern which clearly distinguishes Mediterranean diet for example from a typical American, Eastern European, English, German or Japanese diet.
>Snails ? :) Do they have the right kinds of fats? :) Yep, omega-3, especially alpha-linolenic acid. At least in Crete :-).
 Signature Matti Narkia
Matti Narkia - 22 Sep 2004 20:22 GMT Wed, 22 Sep 2004 22:17:32 +0300 in article <55j3l01l27f437krtk018k0audgkad3533@4ax.com> Matti Narkia <mnng1_REMOVE_THIS@despammed.com> wrote:
>Yep, omega-3, especially alpha-linolenic acid. At least in Crete :-). The last sentence may be significant. Most land snails eat plants and other vegetation, and some wild weeds and herbs in Crete, especially purslane, have high alpha-linolenic acid content.
 Signature Matti Narkia
Matti Narkia - 22 Sep 2004 20:58 GMT Wed, 22 Sep 2004 20:40:29 +0200 in article <2rdus7F17rp3kU1@uni-berlin.de>
>Very good point. One should also take into account general climate in >the area. These things are often being forgotten by experts trying to >explain everything by diet composiion. Yes. Still it has been demonstrated in some studies that many of the health benefits of the traditional Cretan diet are transferrable to other populations and climates by following the main principles of the diet. See the references in the end of this message.
>> The Greek >> Orthodox fasting practices can therefore be characterized as >> requiring a periodic vegetarian diet including fish and >> seafood. > >What nonsense is this? "Vegetarian diet including fish and seafood" ?! Well, perhaps a bit bad formulation of something like "a basically vegetarian diet plus some fish and seafood". The authors are Greek, perhaps they should have used a professional translator :-).
References
1: Kouris-Blazos A, Gnardellis C, Wahlqvist ML, Trichopoulos D, Lukito W, Trichopoulou A. Are the advantages of the Mediterranean diet transferable to other populations? A cohort study in Melbourne, Australia. Br J Nutr. 1999 Jul;82(1):57-61. PMID: 10655957 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1 0655957&dopt=Abstract>
"A prospective cohort study, involving 141 Anglo-Celts and 189 Greek-Australians of both sexes aged 70 years or more, was undertaken in Melbourne, Australia. The objective was to evaluate whether adherence to the principles of the Mediterranean diet affects survival of elderly people in developed non-Mediterranean countries. Diet was assessed using an extensive validated questionnaire on food intake. A one unit increase in a diet score, devised a priori on the basis of eight key features of the traditional common diet in the Mediterranean region, was associated with a 17% reduction in overall mortality (two-tailed P value 0.07). Mortality reduction with increasing diet score was at least as evident among Anglo-Celts as among Greek-Australians. We conclude that a diet that adheres to the principles of the traditional Mediterranean diet is associated with longer survival among Australians of either Greek or Anglo-Celtic origin."
2: Singh RB, Dubnov G, Niaz MA, Ghosh S, Singh R, Rastogi SS, Manor O, Pella D, Berry EM. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet. 2002 Nov 9;360(9344):1455-61 <URL:http://www.thelancet.com/journal/vol360/iss9344/full/llan.360.9344.original_rese arch.23027.1>
3: de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, Delaye J. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994 Jun 11;343(8911):1454-9. Erratum in: Lancet 1995 Mar 18;345(8951):738. PMID: 7911176 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7 911176&dopt=Abstract>
4: Renaud S, de Lorgeril M, Delaye J, Guidollet J, Jacquard F, Mamelle N, Martin JL, Monjaud I, Salen P, Toubol P. Cretan Mediterranean diet for prevention of coronary heart disease. Am J Clin Nutr. 1995 Jun;61(6 Suppl):1360S-1367S. PMID: 7754988 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7 754988&dopt=Abstract>
5: De Lorgeril M, Salen P, Martin JL, Mamelle N, Monjaud I, Touboul P, Delaye J. Effect of a mediterranean type of diet on the rate of cardiovascular complications in patients with coronary artery disease. Insights into the cardioprotective effect of certain nutriments. J Am Coll Cardiol. 1996 Nov 1;28(5):1103-8. <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8 890801&dopt=Abstract>
6: de Lorgeril M, Salen P, Martin JL, Monjaud I, Boucher P, Mamelle N. Mediterranean dietary pattern in a randomized trial: prolonged survival and possible reduced cancer rate. Arch Intern Med. 1998 Jun 8;158(11):1181-7. <URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9 625397&dopt=Abstract>
7: de Lorgeril M, Salen P, Martin J-L, Monjaud I, Delaye J, Mamelle N: Mediterranean diet, traditional risk factors and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation 1999, February 16, 99:779-785 <URL:http://circ.ahajournals.org/cgi/content/full/99/6/779>
8: Leaf A. Dietary prevention of coronary heart disease: the Lyon Diet Heart Study. Circulation. 1999 Feb 16;99(6):733-5. <URL:http://circ.ahajournals.org/cgi/content/full/99/6/733>
9: Serge Renaud: from French paradox to Cretan miracle. Lancet 2000; 355: 48 - 52. <URL:http://www.thelancet.com/journal/vol355/iss9197/full/llan.355.9197.news.2419.1>
 Signature Matti Narkia
Jan - 22 Sep 2004 21:19 GMT > Wed, 22 Sep 2004 20:40:29 +0200 in article <2rdus7F17rp3kU1@uni-berlin.de> > > [quoted text clipped - 6 lines] > populations and climates by following the main principles of the diet. > See the references in the end of this message. I agree that Cretan diet seems to be transferrable to areas as well. Still I would like to add that Cretans live very close to nature. I remember reading that the longest lived people where farmers. I suppose that they spent a lot of time outdoors in the nature. That might have some health benefit also which is not accountable to the diet.
Jan
Matti Narkia - 22 Sep 2004 21:31 GMT 22 Sep 2004 13:19:13 -0700 in article <1095884353.898577.33870@h37g2000oda.googlegroups.com> "Jan" <shantigiri@luukku.com> wrote:
>I agree that Cretan diet seems to be transferrable to areas as well. >Still I would like to add that Cretans live very close to nature. I >remember reading that the longest lived people where farmers. I suppose >that they spent a lot of time outdoors in the nature. That might have >some health benefit also which is not accountable to the diet. Walking probably was an important factor. According to some sources in 1960s and earlier Cretans walked in average about 13 kms in their daily duties.
 Signature Matti Narkia
Lictor - 23 Sep 2004 10:04 GMT > Walking probably was an important factor. According to some sources in 1960s > and earlier Cretans walked in average about 13 kms in their daily duties. Where the average American (with the exception of NYC) walks 500m a day... That's certainly a huge difference! When you see studies establish that even a mere 30 minutes of walking a day is enough to reduce risks for several diseases (CHD, diabete), 13km is *huge*. Another factor is the overall stress level. The whole mediterrannea area has a whole different approach towards work than the USA for instance. French people often get laugh at for being always on hollydays or "RTT", but that's also typical of the overall lifestyle of the area. Life goes beyond what you do in the office, and your job is only a way to earn enough money to enjoy life outside of it. This reduces the need to "perform", and as a result the overall stress level. Moderate alcohol consumption also helps. Stress has been recognized as a major risk factor in many diseases, at least on the same level as diet. The diet itself does not explain everything...
Matti Narkia - 22 Sep 2004 23:12 GMT Wed, 22 Sep 2004 18:46:09 +0200 in article <2rdo5mF19j57qU1@uni-berlin.de>
>> The Cretan diet was also relatively low in carbohydrates (45% >> energy) with most of the carbohydrates consumed being of low > >And low-carb. :) I'm not sure if the Cretan diet can be described as a low carb diet. Perhaps moderate carb, but definitely low glycemic index and low glycemic load.
 Signature Matti Narkia
Mirek Fidler - 23 Sep 2004 19:49 GMT > Wed, 22 Sep 2004 18:46:09 +0200 in article <2rdo5mF19j57qU1@uni-berlin.de> > >> [quoted text clipped - 5 lines] > I'm not sure if the Cretan diet can be described as a low carb diet. Perhaps > moderate carb, but definitely low glycemic index and low glycemic load. Well, depends what you call low-carb. If The Zone or SB are low-carb, mediterranean is definitely too.
Mirek
Matti Narkia - 23 Sep 2004 23:48 GMT Thu, 23 Sep 2004 20:49:34 +0200 in article <2rgjp2F1a6tfuU1@uni-berlin.de>
>> Wed, 22 Sep 2004 18:46:09 +0200 in article ><2rdo5mF19j57qU1@uni-berlin.de> [quoted text clipped - 11 lines] >Well, depends what you call low-carb. If The Zone or SB are low-carb, >mediterranean is definitely too. Zone allows 40% carbohydrates, I wouldn't call it low carb, but moderate carb. I'm not sure about SB. American National Academy of Sciences and American Dietetic Association recommend the average adult consume approximately 45 to 65 percent of daily calories from carbohydrates, so if Cratans had 45% of calories from carbs, that would be just within recommendations and therefore borderline normal carb, but I'm ready to compromise and call it moderate carb ;-). Reading Medline abstracts it seems that the real low carb diets go below 30%, often 10-20%, sometimes even 5%.
 Signature Matti Narkia
Jan - 24 Sep 2004 06:53 GMT > Thu, 23 Sep 2004 20:49:34 +0200 in article <2rgjp2F1a6tfuU1@uni-berlin.de> > [quoted text clipped - 22 lines] > compromise and call it moderate carb ;-). Reading Medline abstracts it seems > that the real low carb diets go below 30%, often 10-20%, sometimes even 5%. I think that you have to keep in mind that the traditional Cretan diet is high in fat (about 40 E%). So, although it might be only _low normal_ in carb, it is not high-protein either because of the high (monounsaturated) fat content.
Jan
Mirek Fidler - 24 Sep 2004 21:38 GMT > Zone allows 40% carbohydrates, I wouldn't call it low carb, but moderate Many do... Just as Dr. Ornish of Mc Dougall :)
> approximately 45 to 65 percent of daily calories from carbohydrates, so if > Cratans had 45% of calories from carbs, that would be just within Many studies describe it as 50% fat. In that case, with some minimal protein, you can easily get under 45.
Mirek
Matti Narkia - 25 Sep 2004 02:52 GMT Fri, 24 Sep 2004 22:38:32 +0200 in article <2rjehaF1b5vn2U1@uni-berlin.de>
>> Zone allows 40% carbohydrates, I wouldn't call it low carb, but >moderate > >Many do... Just as Dr. Ornish of Mc Dougall :) Ornish is a veeryy-low-fat fanatic, who probably regards anything below 55% carbs as a low carb, Mc Dougall doesn't count :-)
 Signature Matti Narkia
Jan - 23 Sep 2004 07:19 GMT > Wed, 22 Sep 2004 16:39:35 +0200 in article <2rdgocF18gmgtU1@uni-berlin.de> > [quoted text clipped - 8 lines] > > See for example Nobody has mentioned the use of honey in the traditional Cretan diet. Perhaps we tend to think that it is not so essential part of a healthy diet, but I think that if we are to learn about the Cretan diet we should have an open and unbiased look at it. Honey is definitely a part of traditional Mediterranean and Cretan diet. Already the Roman Vergilius (70-19 B.C.) praised bees and honey in his Georgica. Especially Cretan thyme honey is a traditional sweetener consumed with joghurt. Also pastries are made with honey. Both honey and thyme are antimicrobial and honey promotes the growth of healthy bifido-bacteria in the gut.
http://www.crete.tournet.gr/cuisine-en.jsp
http://www.crete-today.com/honey/about.htm
BTW, I am aware of the high glycemic index of honey. I am not suggesting its use in massive amounts.
Jan
Mirek Fidler - 23 Sep 2004 19:50 GMT > BTW, I am aware of the high glycemic index of honey. I am not > suggesting its use in massive amounts. I guess that when waling 13km / day, a bit of honey would not harm :)
Mirek
Matti Narkia - 23 Sep 2004 13:31 GMT Wed, 22 Sep 2004 18:42:12 +0300 in article <3t43l0hel2hkt92nsoslse86mqn44ptahe@4ax.com> Matti Narkia <mnng1_REMOVE_THIS@despammed.com> wrote:
>Wed, 22 Sep 2004 16:39:35 +0200 in article <2rdgocF18gmgtU1@uni-berlin.de> > [quoted text clipped - 6 lines] >Mediterranean diets and therefore should perhaps be used as a general >guideline. The scoring system used in the subject study
Mediterranean Diet, Lifestyle Factors, and 10-Year Mortality in Elderly European Men and Women. The HALE Project. Kim T. B. Knoops, MSc; Lisette C. P. G. M. de Groot, PhD; Daan Kromhout, PhD; Anne-Elisabeth Perrin, MD, MSc; Olga Moreiras- Varela, PhD; Alessandro Menotti, MD, PhD; Wija A. van Staveren, PhD JAMA, September 22/29, 2004; 292:1433-1439. <URL:http://jama.ama-assn.org/cgi/content/full/292/12/1433>
is described there as follows:
"To assess the association of diet and the lifestyle factors with mortality, a low-risk group was defined for diet and lifestyle factors. For dietary intake, the low-risk group was defined as those who had a score of at least 4 on a modified version of the Mediterranean diet score proposed by Trichopoulou et al.4 The modified Mediterranean diet score comprised 8 components: ratio of monounsaturated to saturated fat; legumes, nuts, and seeds; grains; fruit; vegetables and potatoes; meat and meat products; dairy products; and fish. Intake of each component was adjusted to daily intakes of 2500 kcal (10.5 MJ) for men and 2000 kcal (8.5 MJ) for women. The sex-specific median intake values were taken as cutoff points. The diet score varied from 0 (low-quality diet) to 8 (high-quality diet). For the components monounsaturated fatty acids to saturated fatty acids (MUFA to SAFA) ratio; fruits and fruit products; vegetables and potatoes; legumes, nuts, and seeds; fish; and grains, a value of 1 was assigned to persons whose consumption was at least as high as the sex-specific median value, and 0 to the others. The vegetables group of the original Mediterranean diet score was replaced by the vegetables and potatoes group because the European classification system (EUROCODE) was used when the 2 food groups were assessed together.16 For meat and meat products and dairy products, a value of 1 was assigned to persons whose consumption was less than the sex- specific median and 0 to the others. The low-risk group for alcohol was defined as those who consumed more than 0 g of alcohol per day. Alcohol consumption was initially divided into 3 groups: 0 g, 1 to 29 g, and 30 g or more of alcohol per day. However, the Kaplan-Meier survival curves of the 3 alcohol groups showed no difference in survival between participants who consumed between 1 g to 29 g of alcohol per day and those who consumed 30 g or more alcohol per day. For smoking, individuals were considered to be at low risk if they had never smoked or had stopped smoking more than 15 years ago.17-19 Individuals with a score in the intermediate and the highest tertile on the Voorrips or Morris questionnaire were considered the low-risk group for physical activity.14-15 A lifestyle score was calculated by adding the individual scores for diet, physical activity level, smoking status, and alcohol intake. Individuals scored 1 point if they belonged to the low-risk group for diet or a particular lifestyle factor and 0 if they belonged to the high-risk group. In total, an individual could obtain 4 points: 1 point for a Mediterranean diet and 3 points for the healthful lifestyle factors."
Te above cited "the Mediterranean diet score proposed by Trichopoulou et al.4" is described in the study
Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003 Jun 26;348(26):2599-608. PMID: 12826634 [PubMed - indexed for MEDLINE] <URL:http://content.nejm.org/cgi/content/full/348/26/2599?ijkey=954de3729cd4bf6a762b3 0acdf92d99b1f97f246>
as follows:
"A scale indicating the degree of adherence to the traditional Mediterranean diet was constructed by Trichopoulou et al.6 and revised to include fish intake.35 A value of 0 or 1 was assigned to each of nine indicated components with the use of the sex- specific median as the cutoff. For beneficial components (vegetables, legumes, fruits and nuts, cereal, and fish), persons whose consumption was below the median were assigned a value of 0, and persons whose consumption was at or above the median were assigned a value of 1. For components presumed to be detrimental (meat, poultry, and dairy products, which are rarely nonfat or low-fat in Greece), persons whose consumption was below the median were assigned a value of 1, and persons whose consumption was at or above the median were assigned a value of 0. For ethanol, a value of 1 was assigned to men who consumed between 10 and 50 g per day and to women who consumed between 5 and 25 g per day. Finally, for fat intake, we used the ratio of monounsaturated lipids to saturated lipids, rather than the ratio of polyunsaturated to saturated lipids, because in Greece, monounsaturated lipids are used in much higher quantities than polyunsaturated lipids. Thus, the total Mediterranean- diet score ranged from 0 (minimal adherence to the traditional Mediterranean diet) to 9 (maximal adherence)."
"A scale indicating the degree of adherence to thetraditional Mediterranean diet was constructed by Trichopoulou et al.6" in the above excerpt refers to the study
Trichopoulou A, Kouris-Blazos A, Wahlqvist ML, Gnardellis C, Lagiou P, Polychronopoulos E, Vassilakou T, Lipworth L, Trichopoulos D. Diet and overall survival in elderly people. BMJ. 1995 Dec 2;311(7018):1457-60. PMID: 8520331 [PubMed - indexed for MEDLINE] <URL:http://bmj.bmjjournals.com/cgi/content/full/311/7018/1457>
An excerpt from there:
"For analysis the frequency of consumption of different food items was quantified approximately in terms of the number of times a month the food was consumed, as done by Graham et al4 and Katsouyanni et al.5 Thus, daily consumption was multiplied by 30 and weekly consumption by 4, a value of 0 was assigned to food items rarely or never consumed. Food items were considered in groups as recommended by Davidson and Passmore6 and used by Graham et al,4 Dales et al,7 and Trichopoulou et al.8 Food frequencies were translated into food quantities in grams per day on the basis of standard portion size estimations, and they were further adjusted to daily intakes of 2500 kcal for men and 2000 kcal for women. Nutrient intakes for individual people were estimated by multiplying the nutrient contents of a selected typical portion for each specified food item by the frequency that the food item was eaten a month and adding these estimates for all food items. Data on the nutrient composition of Greek foods and recipes were based on a nutrient database developed in Greece by the department of nutrition and biochemistry, National School of Public Health.9 The estimation of portion size was based on the results from previous validation studies.3 10 11
Composite scores are often used to describe total diet; these scores are necessary for the evaluation of epidemiological associations,11 12 although they require some operational definitions. We used the food groups recommended by Davidson and Passmore6 in devising a score except that we combined starchy roots with cereals and did not consider sugars and syrups for which no systemic health implications have been documented over and beyond their contribution to net energy intake. The traditional Mediterranean diet is also defined in terms of these food groups with the addition of moderate intake of ethanol13 14 and therefore can be reasonably scored in terms of eight component characteristics: high monounsaturated:saturated fat ratio; moderate ethanol consumption (there were no men who drank more than seven glasses of wine a day and no women who drank more than two glasses of wine a day so that no study subject could be considered a heavy drinker); high consumption of legumes; high consumption of cereals (including bread and potatoes); high consumption of fruits; high consumption of vegetables; low consumption of meat and meat products; and low consumption of milk and dairy products. We used as a cut off point for all characteristics the corresponding median values specific for each sex. We a priori hypothesised that a diet with more of these components has beneficial health effects whereas a diet with fewer of these components would be less healthy. These considerations are based on the collective epidemiological and biological evidence as summarised in the report of the National Academy of Science1 and a recent critical overview.15 In our study sample only 34 subjects (or 19% of the total) were found to have two or fewer of the eight desirable dietary components, whereas 104 subjects (57%) were found to have four or more of the eight desirable components, a reasonable pattern given the attachment of elderly rural Greeks to their traditional diet.
The statistical analysis was undertaken by modelling the data through Cox's proportional hazards regression.16 This approach takes into account not only the event of death but also the time until its occurrence. An assumption in the model is that the rate ratio is constant over follow up time. Initially, eight Cox's models were developed; these controlled for age at enrolment (in three month intervals), sex (0=female, 1=male), and current smoking status (0=non- smoker, 1=smoker) and evaluated alternatively the eight individual components of the diet score adjusted for energy. An additional Cox's model was developed that controlled for age at enrolment, sex, and current smoking status and evaluated the total diet score as a predictor of the hazard of death. Survival curves were plotted by using the Kaplan- Meier method."
 Signature Matti Narkia
tcomeau - 22 Sep 2004 21:53 GMT > Only problem now is to decide what is mediterranean diet... :) > > Mirek Yeah, they seem to think that it is low in animal proteins and fats. I'm not sure that that is accurate.
TC
Matti Narkia - 22 Sep 2004 22:52 GMT 22 Sep 2004 13:53:12 -0700 in article <b550f406.0409221253.1feebaf1@posting.google.com> tunderbar@hotmail.com
>> Only problem now is to decide what is mediterranean diet... :) >> >> Mirek > >Yeah, they seem to think that it is low in animal proteins and fats. >I'm not sure that that is accurate. Who are these "they" and where are they hiding? Certainly I haven't heard of "them". Mediterranean diet is _not_ low in fat. It's moderate to high fat diet. Most of the fat consists of monounsaturated fatty acids from olive oil. Omega-6:omega-3 ratio is very good especially in the traditional Cretan diet. In addition to EPA and DHA from fish and other seafood, the traditional Cretan diet contained a lot of alpha-linolenic acid, mainly from snails and wild plants like purslane. The main sources of animal protein in the traditional Cretan diet were fish and other seafood, dairy products and eggs. Perhaps some poultry. Vegetable sources of protein such as beans and other legumes, nuts and whole meal grain products were used in larger quantity than animals sources of protein. Red meat was rarely consumed, perhaps once in a month. Even then it was meat of goats and sheep, which had been eating wild grass and plants with relatively high omega-3 content. Therefore the fatty acid profile of the meat consumed deviated greatly from the meat of grain fed animals.
 Signature Matti Narkia
Matti Narkia - 23 Sep 2004 00:10 GMT 22 Sep 2004 13:37:33 GMT in article
>Here is another news article how this diet increases by 50 percent life >span in the elderly: > >http://www.eurekalert.org/pub_releases/2004-09/jaaj-mda091604.php This study is
Mediterranean Diet, Lifestyle Factors, and 10-Year Mortality in Elderly European Men and Women. The HALE Project. Kim T. B. Knoops, MSc; Lisette C. P. G. M. de Groot, PhD; Daan Kromhout, PhD; Anne-Elisabeth Perrin, MD, MSc; Olga Moreiras-Varela, PhD; Alessandro Menotti, MD, PhD; Wija A. van Staveren, PhD JAMA, September 22/29, 2004; 292:1433-1439. <URL:http://jama.ama-assn.org/cgi/content/full/292/12/1433>
The full text is freely available on-line.
In the same issue of JAMA there is also another study about Mediterranean diet:
Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome. A Randomized Trial. Katherine Esposito, MD; Raffaele Marfella, MD, PhD; Miryam Ciotola, MD; Carmen Di Palo, MD; Francesco Giugliano, MD; Giovanni Giugliano, MD; Massimo D'Armiento, MD; Francesco D'Andrea, MD; Dario Giugliano, MD, PhD JAMA, September 22/29, 2004; 292:1440-1446. <URL:http://jama.ama-assn.org/cgi/content/short/292/12/1440>
 Signature Matti Narkia
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