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Medical Forum / General / Nutrition / July 2004

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Stockholders share not Healthcare: U.S. taken to task over AIDS drug policy

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Zee - 14 Jul 2004 06:25 GMT
Amazing isn't it, people dying from illnesses that could be beaten if
STOCKHOLDERS SHARE would just take a back seat to HEALTHCARE. In the
meantime, BILLIONS are spent developing lifestyle drugs, like statins
and viagra.

http://www.theglobeandmail.com/servlet/ArticleNews/TPStory/LAC/20040712/AIDS12/T
PHealth/


"As a result, U.S.-funded AIDS programs in poor
countries are able to buy only those drugs
approved by the U.S. Food and Drug
Administration."

U.S. taken to task over AIDS drug policy

Insistence on buying only FDA-approved medicine
draws fire at annual meeting

By STEPHANIE NOLEN
Monday, July 12, 2004 - Page A3

BANGKOK -- The 15th International AIDS Conference
opened with a mood of tension in the Thai capital
yesterday, with the United States standing
increasingly isolated in its insistence on the
use of brand-name drugs for the treatment of
people with AIDS.

Activists and leaders of the United Nations AIDS
treatment efforts were critical of the U.S.
program, saying it is spending two to three times
more than necessary to supply patients in Asia
and Africa with brand-name anti-retroviral drugs
from large drug companies.

Randall Tobias, the U.S. government's global AIDS
co-ordinator, said Washington's program is open
to the use of generic drugs. "Our policy is to
buy the least expensive drugs we can find
anywhere in the world -- without regard to
whether they are brand-name or generic," as long
as those drugs are safe, he told reporters.

But Mr. Tobias, a former head of the
pharmaceutical firm Eli Lilly and Co., also
insisted that there should be no "double
standard" between the drugs used in poor
countries and the West. As a result, U.S.-funded
AIDS programs in poor countries are able to buy
only those drugs approved by the U.S. Food and
Drug Administration.
Robert - 14 Jul 2004 08:57 GMT
The answer is using condoms and preventing the spread of HIV. Takes drugs
does not do anything to transmission and only makes it worse. People don't
want to be tested because of the stigma associated with the diagnoses as a
result more people spread it and are thrown out of their own home with that
diagnosis. If you think the statins are dangerous then try the HIV drugs and
their side effects. As with statins HIV drugs need to be monitored with
blood tests which are too costly for third world countries. Unless those
problems are addressed to simply put it on the door step of the drug
companies is stupid.

> Amazing isn't it, people dying from illnesses that could be beaten if
> STOCKHOLDERS SHARE would just take a back seat to HEALTHCARE. In the
> meantime, BILLIONS are spent developing lifestyle drugs, like statins
> and viagra.

http://www.theglobeandmail.com/servlet/ArticleNews/TPStory/LAC/20040712/AIDS12/T
PHealth/


> "As a result, U.S.-funded AIDS programs in poor
> countries are able to buy only those drugs
[quoted text clipped - 39 lines]
> only those drugs approved by the U.S. Food and
> Drug Administration.
GMCarter - 14 Jul 2004 12:43 GMT
>The answer is using condoms and preventing the spread of HIV. Takes drugs
>does not do anything to transmission and only makes it worse.

No, that's untrue. ARV lowers viral load also in the seminal
compartment. Use of condoms will be necessary, in addition, of course.

>People don't
>want to be tested because of the stigma associated with the diagnoses as a
[quoted text clipped - 4 lines]
>problems are addressed to simply put it on the door step of the drug
>companies is stupid.

As to ARV vs. statin toxicities, I agree. However, the rest of your
comment is incorrect.

There are means to evaluate CD4 counts and viral load
(heat-dissociated p24, for example) that provide the basic information
that is needed for managing HIV disease in the context of ARV.

However, diagnostic costs, like drugs, have been artificially driven
into the stratosphere by the out-of-control pharmaceutical industry.
They are SO greedy, they are willing to kill and harm millions to
assure their profits.

That is genocide.

        George M. Carter
Robert - 14 Jul 2004 19:26 GMT
"GMCarter" <fiar@verizon.net> wrote in message >
> There are means to evaluate CD4 counts and viral load
> (heat-dissociated p24, for example) that provide the basic information
[quoted text clipped - 8 lines]
>
> George M. Carter

As I said unless those other things are addressed taking a pill will not do
anything but breed resistance in the non compliance because of the nausea
and diarrhea and you name it.
GMCarter - 15 Jul 2004 10:05 GMT
>"GMCarter" <fiar@verizon.net> wrote in message >
>> There are means to evaluate CD4 counts and viral load
[quoted text clipped - 13 lines]
>anything but breed resistance in the non compliance because of the nausea
>and diarrhea and you name it.

People don't have much sex when suffering those particular symptoms, I
can assure you.

NOT taking the ARV will not reduce transmission rates as people have a
long incubation period (from 2-8 years--sometimes longer). It is
better to treat because

A) It is humane (which should be enough);
B) It reduces viral load;
C) it prevents early death, the numbers of which are destabilizing
economies.

Adherence is an important piece. As is food, clean water, trained
outreach workers, nurses and physicians. These are all quite do-able.

        George M. Carter
Robert - 15 Jul 2004 19:33 GMT
"GMCarter" <fiar@verizon.net> wrote in message > >>
> >As I said unless those other things are addressed taking a pill will not do
> >anything but breed resistance in the non compliance because of the nausea
> >and diarrhea and you name it.
>
> People don't have much sex when suffering those particular symptoms, I
> can assure you.

Thats why they are non compliant and only take sporadic drugs.

> NOT taking the ARV will not reduce transmission rates as people have a
> long incubation period (from 2-8 years--sometimes longer). It is
[quoted text clipped - 9 lines]
>
> George M. Carter

George the only answer is in finding a vaccine. Historically within the
context of third world countries that is the only thing they will be able to
afford.
It is the only answer that makes any sense.
GMCarter - 21 Jul 2004 10:31 GMT
>"GMCarter" <fiar@verizon.net> wrote in message > >>
>> >As I said unless those other things are addressed taking a pill will not
[quoted text clipped - 6 lines]
>
>Thats why they are non compliant and only take sporadic drugs.

Adherence is a problem. Interestingly, the studies in poor, rural and
other communities from Haiti to Africa show very high rates of
adherence. Limited adherence among some is not a reason to deny
treatment.

>> NOT taking the ARV will not reduce transmission rates as people have a
>> long incubation period (from 2-8 years--sometimes longer). It is
[quoted text clipped - 14 lines]
>afford.
>It is the only answer that makes any sense.

I agree it is the BEST answer--preferably one that acts both as a
preventative and as a therapeutic (although *stimulating* immunity may
be the a.s-backwards thing to do in HIV disease--recent data, e.g.,
sooty mangabeys, suggest that immune activation may be why CD4+ cells
die....In sooty mangabeys, they have active, productive infections of
SIV that has been around--but their immune system essentially ignores
it....transfer that SIV to a macaque, the imm sys recognises it but
with the consequence of CD4 loss and the development of AIDS.)

In the meantime, though, we need prevention AND treatment.

        George M. Carter
tcomeau - 14 Jul 2004 15:41 GMT
HIV has never been isolated and thus the HIV/AIDS connection has never
met Koch's Postulates.

TC

> The answer is using condoms and preventing the spread of HIV. Takes drugs
> does not do anything to transmission and only makes it worse. People don't
[quoted text clipped - 56 lines]
> > only those drugs approved by the U.S. Food and
> > Drug Administration.
Robert - 14 Jul 2004 19:28 GMT
> HIV has never been isolated and thus the HIV/AIDS connection has never
> met Koch's Postulates.
>
> TC

I answered that previously moron but I hope you continue to mention it in
your posts because I want people to see what an idiot you are. No one would
even consider taking their dog to you for medcial advice much less
themselves.

> > The answer is using condoms and preventing the spread of HIV. Takes drugs
> > does not do anything to transmission and only makes it worse. People don't
[quoted text clipped - 10 lines]
> > > meantime, BILLIONS are spent developing lifestyle drugs, like statins
> > > and viagra.

http://www.theglobeandmail.com/servlet/ArticleNews/TPStory/LAC/20040712/AIDS12/T
PHealth/


> > > "As a result, U.S.-funded AIDS programs in poor
> > > countries are able to buy only those drugs
[quoted text clipped - 39 lines]
> > > only those drugs approved by the U.S. Food and
> > > Drug Administration.
tcomeau - 15 Jul 2004 15:52 GMT
> > HIV has never been isolated and thus the HIV/AIDS connection has never
> > met Koch's Postulates.
[quoted text clipped - 5 lines]
> even consider taking their dog to you for medcial advice much less
> themselves.

Can you show me the paper that shows definitively that Koch's
postulates have been definitively met in the case of HIV/AIDS and/or
shows that HIV has been properly isolated?

TC
GMCarter - 15 Jul 2004 10:05 GMT
>HIV has never been isolated and thus the HIV/AIDS connection has never
>met Koch's Postulates.

This is nonsense, my friend. HIV HAS been isolated. And HIV disease
DOES lead to AIDS and DOES fulfill Koch's postulates.

    George M. Carter
tcomeau - 15 Jul 2004 15:49 GMT
> >HIV has never been isolated and thus the HIV/AIDS connection has never
> >met Koch's Postulates.
[quoted text clipped - 3 lines]
>
>     George M. Carter

I notice that you make no references to published papers that show
this to be the case.

TC
GMCarter - 21 Jul 2004 10:35 GMT
>> >HIV has never been isolated and thus the HIV/AIDS connection has never
>> >met Koch's Postulates.
[quoted text clipped - 6 lines]
>I notice that you make no references to published papers that show
>this to be the case.

There are numerous such papers.  See, e.g., Science. 1994 Dec
9;266(5191):1647. Another:
Harden VA. Koch's postulates and the etiology of AIDS: an historical
perspective. Hist Philos Life Sci. 1992;14(2):249-69.

See also:
http://www.niaid.nih.gov/publications/hivaids/12.htm

        George M. Carter
tcomeau - 21 Jul 2004 19:20 GMT
> >> >HIV has never been isolated and thus the HIV/AIDS connection has never
> >> >met Koch's Postulates.
[quoted text clipped - 16 lines]
>
>         George M. Carter

Koch's Postulates don't work that way.  The paper you referenced
pieces together a variety of unrelated events that give the appearance
of HIV/AIDS meeting Koch's Postulates.

Here are Koch's Postulates:

1. The specific organism should be shown to be present in all cases of
animals suffering from a specific disease but should not be found in
healthy animals.

TC: Many with Acquired Immune Deficiency-type Syndromes are not HIV
positive. In North America you can have all the medical hallmarks of
AIDS and still not be diagnosed with AIDS if you are HIV negative.
Many with HIV never develop AIDS. In parts of Africa, HIV is not even
part of the definition of AIDS.

2. The specific microorganism should be isolated from the diseased
animal and grown in pure culture on artificial laboratory media.

TC:Never been done. If it was done, show me the paper. Show me the
micrograph of the isolated and purified retro-virus.

3. This freshly isolated microorganism, when inoculated into a healthy
laboratory animal, should cause the same disease seen in the original
animal.

TC: never been done.

4. The microorganism should be reisolated in pure culture from the
experimental infection.

TC: never been done.

Furthermore, Koch's Postulates cannot be met by showing various
unrelated events and tieing them together.

Koch's Postulates involves taking an infected animal and extracting
the and isolating the pathogen from it, then taking that very same
isolated pathogen and using it to innoculate another specific animal,
then once that very same animal develops the symptoms, the pathogen is
then re-isolated from that animal.

The example you showed me makes a mockery of Koch's Postulates and is
about as nebulous a piece of pseudo-science as there exists.

TC
GMCarter - 22 Jul 2004 00:40 GMT
snip..

>Koch's Postulates don't work that way.  The paper you referenced
>pieces together a variety of unrelated events that give the appearance
>of HIV/AIDS meeting Koch's Postulates.

Ah, I think some of the people referenced might have an idea of how
Koch's postulates work. They reflect a framework, not a set of laws.

>Here are Koch's Postulates:
>
[quoted text clipped - 7 lines]
>Many with HIV never develop AIDS. In parts of Africa, HIV is not even
>part of the definition of AIDS.

These are not rational arguments. Many people with congestion and
coughing are not suffering from tuberculosis. It does not mean
Mycobacterium tuberculosis does not exist. Many people with TB have a
chronic condition which does not cause disease (although it may
reactivate). Indeed, the horrible thing about HIV is that so FEW
infected individuals (maybe 8-12%) are very slow or non-progressors.

>2. The specific microorganism should be isolated from the diseased
>animal and grown in pure culture on artificial laboratory media.
>
>TC:Never been done. If it was done, show me the paper. Show me the
>micrograph of the isolated and purified retro-virus.

Oh, horseshit. The denialist view on isolation demands that a sucrose
density gradient test be used that is from the 70s--and curiously one
of the authors they cite is a woman named Francoise Barre-Sinoussi.
Guess what? SHE is the discoverer of LAV (later HIV-1) from Pasteur
Institute! It's just nonsense. I won't show you ONE paper--there are
DOZENS of papers (and micrographs) that show HIV exists.

>3. This freshly isolated microorganism, when inoculated into a healthy
>laboratory animal, should cause the same disease seen in the original
>animal.
>
>TC: never been done.

Yes it has. Chimpanzees.

>4. The microorganism should be reisolated in pure culture from the
>experimental infection.
>
>TC: never been done.

Yes it has.

>Furthermore, Koch's Postulates cannot be met by showing various
>unrelated events and tieing them together.
[quoted text clipped - 7 lines]
>The example you showed me makes a mockery of Koch's Postulates and is
>about as nebulous a piece of pseudo-science as there exists.

Actually, what you have just projectile vomited is just denialist
horseshit that has been refuted time and time again. Sadly, the few
HIV+ people I have known who bought this codswallop died of AIDS.
Including a big proponent of this nonsense, David Pasquarelli.

You don't believe me? Cool. I hope you don't have to do your own "n of
1" study of getting infected and watching your magicaly mystery CD4
cells plummet to zero and the concomitant and often lethal infections
that arise.

Tom, I agree with you on a lot of things. But not THIS. THIS one
deflects from so many more important and horrifying situations that
ARE genuine horrors. Pharma's despicable acts in blocking access to
generic medications. The failure to do research on tropical diseases.
the lies of patents inducing R&D (when pipelines are narrowing).

Drugs have value. They have limitations. Just like botanicals and
minerals and prayer and diet and stress reduction and love.

As a person living with Hepatitis C, I can tell you, I am interested
in what works and understanding its benefits, costs and limitations.
And having so many HIV+ friends and losing so many, I am quite sure
that HIV exists and causes AIDS.

        George M. Carter

        George M. Carter
 
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