Fam Med. 2004 May
The combined effect of transferrin saturation and low density lipoprotein on
mortality.
Wells BJ, Mainous AG 3rd, King DE, Gill JM, Carek PJ, Geesey ME.
Department of Family Medicine, Medical University of South Carolina, Charleston
29425, USA. wellsbj@musc.edu
BACKGROUND AND OBJECTIVES: Evidence suggests that cardiovascular disease (CVD)
is accelerated by the oxidation of low-density lipoprotein (LDL) in the
presence of iron. This study examined whether adults with elevated iron, as
measured by transferrin saturation (TS), and elevated LDL are at an increased
risk for mortality. METHODS: This is a cohort study of the adult US population
using the National Health and Nutrition Examination Survey 1976-1980 (NHANES
II) merged with the NHANES II Mortality Study in 1992. Multivariate Cox
regression was performed to determine hazard ratios (HR) for CVD and all-cause
mortality for high (>55%) or low (<55%) levels of TS and high (>160 mg/dl) or
low (<160 mg/dl) levels of LDL. RESULTS: An elevated LDL alone did not
significantly increase CVD mortality or all-cause mortality in the adjusted
model. Individuals with elevated LDL and elevated TS had a statistically
significant increase in both CVD mortality and all-cause mortality (HR=5.74 and
3.53, respectively) compared to the low LDL and low TS group. CONCLUSIONS: The
results of this study indicate an increased risk associated with the
combination of elevated LDL and elevated TS, which suggests that iron-mediated
oxidation of LDL may be a significant factor in the progression of CVD.
http://tinyurl.com/3guhl
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markd@toad-net.com - 28 Jun 2004 13:36 GMT
>presence of iron. This study examined whether adults with elevated iron, as
>measured by transferrin saturation (TS), and elevated LDL are at an increased
The cutoff they used for ts is 55, which means that about 3 percent of the
population is being included in the study. As with most of the iron info
posted, looking at fringe situations means little for most of the
population with regard to iron levels.
doe - 28 Jun 2004 16:51 GMT
>Subject: Re: iron-mediated oxidation of LDL / mortality
>From: markd@toad-net.com
[quoted text clipped - 8 lines]
>The cutoff they used for ts is 55, which means that about 3 percent of the
>population is being included in the study.
You've brought your .. expertise .. IN .. epidemiology into the discussion more
than . once ..
With the rate of iron loading thalassemia in the world .. WHERE have you gotten
your 3% of the population .. from ..?
Cite .. it .. you .. fk ..
Or stay the fk off my threads ..
You fkgcomprendez ..?
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doe - 28 Jun 2004 17:47 GMT
>Subject: Re: iron-mediated oxidation of LDL / mortality
>From: ironjustice@aol.comdoe (doe)
>Date: 6/28/2004 9:51 AM Mountain Daylight Time
>Message-id: <20040628115104.15872.00000562@mb-m21.aol.com>
>>>presence of iron. This study examined whether adults with elevated iron,
>>as
[quoted text clipped - 17 lines]
>
>You fkgcomprendez ..?
Surprise .. fkg .. surprise ..
markd .. without . cites ..
Heh .. heh ..
Full of sht ..
More like .. thirty percent ..
<<snip>>
1330 were positive (27.6%) and almost all of this group were proved to be the
thalassemia trait
<<snip>>
English Abstract :
This retrospective descriptive study is aimed to evaluate ?Prevention and
Control of Thalassemia Program? in Buddhachinaraj Hospital during 1999 - 2002.
Four thousand, eight hundred and twenty six pregnant women were screened and
1330 were positive (27.6%) and almost all of this group were proved to be ?the
thalassemia trait?. In thalassemia trait group, thirty percent were found to be
a late attendants (first visit later than 20 week?s gestation). Most
thalassemia trait was hemoglobin E trait and homozygous Hb E (93.3 %) but low
rate of ?-Thalassemia trait (3.8%). Only approximately half of the husbands of
the positive cases were given counseling and had blood tests. About one third
were positive and the distribution of trait group were similar to the positive
pregnant women group. It was disclosed that 16 couples were at risk which
represented 1.2 percent of the total positive cases. Only three pregnant women
underwent cordocentesis. Four main problems were addressed; a low rate of
husband tested, a low rate of cordocentesis in couples at risk group, a high
rate of late ANC and no ?-thalassemia were screened. It is highly recommended
that all staff should improve the counseling process. After the year 2002, the
Health Research Institute, Naresuan University was contacted for more screening
of ?-thalassemia. Government should support the budget for the antenatal
diagnosis.
English Keyword: thalassemia screening, thalassemia trait, couple at risk
>Who loves ya.
>Tom

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