 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / General / Nutrition / March 2004Thalassemia / tocopherol / vitamin E
Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Das N, Chowdhury TD, Chattopadhyay A, Datta AG. Department of Life Science and Biotechnology, Jadavpur University, Kolkata - 700 032, India. dbandyo_5@yahoo.com; assoke_datta@yahoo.com The oxidative stress status of the transfusion-dependant Ebeta- and beta-thalassemia patients were studied before and after treatment with vitamin E for a period of four weeks. The level of cellular vitamin antioxidants viz. ascorbic acid and vitamin E in the thalassemia patients were found to be considerably lower compared to normal subjects. The activities of enzymatic antioxidants viz. catalase, glutathione peroxidase and glutathione reductase were found to be drastically reduced in untreated Ebeta- and beta-thalassemic patients when compared to normal subjects. However, the activity of superoxide dis-mutase was found to be increased in both types of untreated thalassemic patients when compared to normal individuals. An increase in superoxide dismutase and a decrease in catalase activity reflects the presence of a severe oxidative stress situation in the erythrocytes of the untreated transfusion dependant Ebeta- and beta-thalassemia patients. Changes in erythrocyte membrane protein pattern in untreated Ebeta- and beta-thalassemia patients when compared to normal erythrocyte further confirm the presence of continued oxidative stress in the ailing thalassemic erythrocytes. All these changes in the antioxidant status as well as the changes in the erythrocyte membrane proteins are ameliorated to considerable extent when the transfusion-dependent Ebeta- and beta-thalassemia patients were treated with vitamin E at a dose of 10 mg/kg/day for a period of four weeks. The patients during the treatment period did not exhibit any side effects and gained in body weight indicating a healthy status. The present study reveals that the lipophilic antioxidant vitamin E could be useful in the management of transfusion-dependant Ebeta- and beta-thalassemia patients. PMID: 15047982 [PubMed - in process] -------------------------------------------------------------------------- ------ Who loves ya. Tom  SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking And what exactly are we to make of this, how does it relate to any body of theory, to what practical use is it, and to what goal can it be useful? Without this information it is but another random abstract plucked from the web, one among thousands of such. >Subject: Re: Thalassemia / tocopherol / vitamin E >From: markd@toad-net.com [quoted text clipped - 5 lines] >Without this information it is but another random abstract plucked from >the web, one among thousands of such. Jeez .. can't even understand a simple medical study ..? Right after the word .. 'conclusion' .. comes this phrase .. vitamin E could be useful in the management of transfusion-dependant Ebeta- and beta-thalassemia patients Little advice .. right after .. the .. word .. conclusion .. in .. a .. medical .. study .. comes .. some .. important .. relevant .. information .. pertaining .. to .. the .. medical .. study .. Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Das N, Chowdhury TD, Chattopadhyay A, Datta AG. Department of Life Science and Biotechnology, Jadavpur University, Kolkata - 700 032, India. dbandyo_5@yahoo.com; assoke_datta@yahoo.com The oxidative stress status of the transfusion-dependant Ebeta- and beta-thalassemia patients were studied before and after treatment with vitamin E for a period of four weeks. The level of cellular vitamin antioxidants viz. ascorbic acid and vitamin E in the thalassemia patients were found to be considerably lower compared to normal subjects. The activities of enzymatic antioxidants viz. catalase, glutathione peroxidase and glutathione reductase were found to be drastically reduced in untreated Ebeta- and beta-thalassemic patients when compared to normal subjects. However, the activity of superoxide dis-mutase was found to be increased in both types of untreated thalassemic patients when compared to normal individuals. An increase in superoxide dismutase and a decrease in catalase activity reflects the presence of a severe oxidative stress situation in the erythrocytes of the untreated transfusion dependant Ebeta- and beta-thalassemia patients. Changes in erythrocyte membrane protein pattern in untreated Ebeta- and beta-thalassemia patients when compared to normal erythrocyte further confirm the presence of continued oxidative stress in the ailing thalassemic erythrocytes. All these changes in the antioxidant status as well as the changes in the erythrocyte membrane proteins are ameliorated to considerable extent when the transfusion-dependent Ebeta- and beta-thalassemia patients were treated with vitamin E at a dose of 10 mg/kg/day for a period of four weeks. The patients during the treatment period did not exhibit any side effects and gained in body weight indicating a healthy status. The present study reveals that the lipophilic antioxidant vitamin E could be useful in the management of transfusion-dependant Ebeta- and beta-thalassemia patients. PMID: 15047982 [PubMed - in process] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Ah, so when you are a doc you can use this for transfusions,ie. increasing the iron level by introducing it externally? A very clever approach to iron anemia indeed, why didn't I think of that? >Subject: Re: Thalassemia / tocopherol / vitamin E >From: markd@toad-net.com [quoted text clipped - 3 lines] >Ah, so when you are a doc you can use this for transfusions,ie. increasing >the iron level by introducing it externally? No .. it .. simply .. CONFIRMS .. a lack of tocopherol in thalassemia patients .. Pretty straight forward and easy to understand .. actually .. YOU .. though .. somehow miss this .. Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Das N, Chowdhury TD, Chattopadhyay A, Datta AG. Department of Life Science and Biotechnology, Jadavpur University, Kolkata - 700 032, India. dbandyo_5@yahoo.com; assoke_datta@yahoo.com The oxidative stress status of the transfusion-dependant Ebeta- and beta-thalassemia patients were studied before and after treatment with vitamin E for a period of four weeks. The level of cellular vitamin antioxidants viz. ascorbic acid and vitamin E in the thalassemia patients were found to be considerably lower compared to normal subjects. The activities of enzymatic antioxidants viz. catalase, glutathione peroxidase and glutathione reductase were found to be drastically reduced in untreated Ebeta- and beta-thalassemic patients when compared to normal subjects. However, the activity of superoxide dis-mutase was found to be increased in both types of untreated thalassemic patients when compared to normal individuals. An increase in superoxide dismutase and a decrease in catalase activity reflects the presence of a severe oxidative stress situation in the erythrocytes of the untreated transfusion dependant Ebeta- and beta-thalassemia patients. Changes in erythrocyte membrane protein pattern in untreated Ebeta- and beta-thalassemia patients when compared to normal erythrocyte further confirm the presence of continued oxidative stress in the ailing thalassemic erythrocytes. All these changes in the antioxidant status as well as the changes in the erythrocyte membrane proteins are ameliorated to considerable extent when the transfusion-dependent Ebeta- and beta-thalassemia patients were treated with vitamin E at a dose of 10 mg/kg/day for a period of four weeks. The patients during the treatment period did not exhibit any side effects and gained in body weight indicating a healthy status. The present study reveals that the lipophilic antioxidant vitamin E could be useful in the management of transfusion-dependant Ebeta- and beta-thalassemia patients. PMID: 15047982 [PubMed - in process] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Smile, Tom I didn't miss it at all. I could not resist to once again tinkle your bell, I'm so weak to resist temptation. But you must agree, to reuce iron anemia rapidly, transfusions are a way to go. On the other hand, just think of all that good vit e one loses at the blood bank. >Subject: Re: Thalassemia / tocopherol / vitamin E Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Das N, Chowdhury TD, Chattopadhyay A, Datta AG. Department of Life Science and Biotechnology, Jadavpur University, Kolkata - 700 032, India. dbandyo_5@yahoo.com; assoke_datta@yahoo.com The oxidative stress status of the transfusion-dependant Ebeta- and beta-thalassemia patients were studied before and after treatment with vitamin E for a period of four weeks. The level of cellular vitamin antioxidants viz. ascorbic acid and vitamin E in the thalassemia patients were found to be considerably lower compared to normal subjects. The activities of enzymatic antioxidants viz. catalase, glutathione peroxidase and glutathione reductase were found to be drastically reduced in untreated Ebeta- and beta-thalassemic patients when compared to normal subjects. However, the activity of superoxide dis-mutase was found to be increased in both types of untreated thalassemic patients when compared to normal individuals. An increase in superoxide dismutase and a decrease in catalase activity reflects the presence of a severe oxidative stress situation in the erythrocytes of the untreated transfusion dependant Ebeta- and beta-thalassemia patients. Changes in erythrocyte membrane protein pattern in untreated Ebeta- and beta-thalassemia patients when compared to normal erythrocyte further confirm the presence of continued oxidative stress in the ailing thalassemic erythrocytes. All these changes in the antioxidant status as well as the changes in the erythrocyte membrane proteins are ameliorated to considerable extent when the transfusion-dependent Ebeta- and beta-thalassemia patients were treated with vitamin E at a dose of 10 mg/kg/day for a period of four weeks. The patients during the treatment period did not exhibit any side effects and gained in body weight indicating a healthy status. The present study reveals that the lipophilic antioxidant vitamin E could be useful in the management of transfusion-dependant Ebeta- and beta-thalassemia patients. PMID: 15047982 [PubMed - in process] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Folk who need blood transfusions for a specific disease do better when vits c e are provided. People who give blood have less of everything that isgood in blood. >Subject: Re: Thalassemia / tocopherol / vitamin E >From: markd@toad-net.com [quoted text clipped - 3 lines] >Folk who need blood transfusions for a specific disease do better when >vits c e are provided. Very .. good .. Pol J Pharmacol. 2004 Jan-Feb;56(1):85-96. Related Articles, Links Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin E. Das N, Chowdhury TD, Chattopadhyay A, Datta AG. Department of Life Science and Biotechnology, Jadavpur University, Kolkata - 700 032, India. dbandyo_5@yahoo.com; assoke_datta@yahoo.com The oxidative stress status of the transfusion-dependant Ebeta- and beta-thalassemia patients were studied before and after treatment with vitamin E for a period of four weeks. The level of cellular vitamin antioxidants viz. ascorbic acid and vitamin E in the thalassemia patients were found to be considerably lower compared to normal subjects. The activities of enzymatic antioxidants viz. catalase, glutathione peroxidase and glutathione reductase were found to be drastically reduced in untreated Ebeta- and beta-thalassemic patients when compared to normal subjects. However, the activity of superoxide dis-mutase was found to be increased in both types of untreated thalassemic patients when compared to normal individuals. An increase in superoxide dismutase and a decrease in catalase activity reflects the presence of a severe oxidative stress situation in the erythrocytes of the untreated transfusion dependant Ebeta- and beta-thalassemia patients. Changes in erythrocyte membrane protein pattern in untreated Ebeta- and beta-thalassemia patients when compared to normal erythrocyte further confirm the presence of continued oxidative stress in the ailing thalassemic erythrocytes. All these changes in the antioxidant status as well as the changes in the erythrocyte membrane proteins are ameliorated to considerable extent when the transfusion-dependent Ebeta- and beta-thalassemia patients were treated with vitamin E at a dose of 10 mg/kg/day for a period of four weeks. The patients during the treatment period did not exhibit any side effects and gained in body weight indicating a healthy status. The present study reveals that the lipophilic antioxidant vitamin E could be useful in the management of transfusion-dependant Ebeta- and beta-thalassemia patients. PMID: 15047982 [PubMed - in process] -------------------------------------------------------------------------- ------ Who loves ya. Tom SignatureJesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking So Tom, are you planning to have transfusions in the near future, otherwise what is the purpose of posting the abstract, the original question? Remember, all the good things in blood is lost when giving blood. |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.