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Medical Forum / General / General / March 2007

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What became of Lopinavir as a treatment of HPV?

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MikeyMuchos - 28 Feb 2007 11:18 GMT
Hi,
I don't suffer from this problem as far as I know but I have people
close to me who do.  So, when I saw this article on the BBC website
during August 2006 I was overjoyed at the prospect of this new and
effective, non-surgical treatment for HPV.

http://news.bbc.co.uk/1/hi/health/5282206.stm

Since then, I haven't been able to find any information on the
development of this remedy, other than the few original "fanfare"
announcements which appeared around the time of the linked BBC
article. Maybe this is a common fate of many revolutionary new
medicines, which don't quite make it into the real world.

One of the more interesting features of this particular antiviral drug
"Lopinavir" is that it's already extensively produced and used in the
treatment of AIDS. Also, when used as a topical application to the
cervix in the form of a  cream or pessary "...the actual concentration
needed in the lab was a millionth of that used orally to treat
HIV. ..."

So, the drug is in mainstream production and for HPV treatment only a
minute dosage is required. It must be worth making some effort to find
out where the sticking point is with the development of this
treatment. If it's a patent or a pricing problem, which isn't going to
be resolved too easily, my thought is that it might be worth finding a
way to purchase the generic drug from some Asian pharmaceutical
source. This way, those who suffer from HPV might aquire an effective
treatment for their condition, which doesn't rely on comparatively
crude surgical measures.

Any comments on this would be most welcome.

Best wishes,
Mikey Muchos
Bob - 02 Mar 2007 02:13 GMT
>Hi,
>I don't suffer from this problem as far as I know but I have people
[quoted text clipped - 3 lines]
>
>http://news.bbc.co.uk/1/hi/health/5282206.stm

The key statement there is
"Dr Ian Hampson and his team are hopeful that the HIV
drug will do the same in real life and plan to carry
out clinical trials in women soon."

That is, so far all they have done is to work with lab cells. Now they
will try to see if it works in real people. At this point, they have
no idea. Is there any reason to believe it will work as a topical?
Time will tell. That is why they do clinical trials.

bob
MikeyMuchos - 02 Mar 2007 08:08 GMT
> >Hi,
> >I don't suffer from this problem as far as I know but I have people
[quoted text clipped - 15 lines]
>
> bob

Thanks, every little helps.

MikeyMuchos
 
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