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Medical Forum / General / General / January 2007

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Head Trauma

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dan@nospam.com - 17 Jan 2007 19:41 GMT
Hello,

My brother sustained head trauma in a car accident about 20 years ago.
He lost his peripheral vision, sense of smell, and hearing in one ear.
Given all this damage he still functions well.  I am wondering if stem
cell research offers any promise to restore my brother to full functioning.

TIA,
Dan
Bob - 18 Jan 2007 03:53 GMT
>Hello,
>
>My brother sustained head trauma in a car accident about 20 years ago.
>He lost his peripheral vision, sense of smell, and hearing in one ear.
>Given all this damage he still functions well.  I am wondering if stem
>cell research offers any promise to restore my brother to full functioning.

Interesting question.

The first thing to understand is that there are no accepted treatments
for anything at this point using stem cells (other than the
long-established bone marrow transplant). The field is in its infancy.

As to what may become possible, who knows? But a requirement will be
-- almost certainly -- to know the specific defect, at the cellular
level.

bob
dan@nospam.com - 18 Jan 2007 16:35 GMT
>> Hello,
>>
[quoted text clipped - 14 lines]
>
> bob

My understanding is that all his damage is nerves so I thought with the
experiments of repairing rats severed spines to 75% function may mean
other nerve path ways may be able to be repaired eventually.

Dan
Bob - 22 Jan 2007 02:47 GMT
>>> Hello,
>>>
[quoted text clipped - 18 lines]
>experiments of repairing rats severed spines to 75% function may mean
>other nerve path ways may be able to be repaired eventually.

Good thought.

The reservation is about the time scale of making it happen; the
principle is fine.

The rat work you refer to is promising, but it takes a while to
translate such things to humans. People are extremely cautious in
developing new medical procedures for humans. One can argue that they
are too cautious, but there is fear about doing harm. Of particular
concern is long term effects, which of course take a while to show up.
One consequence is that early work is usually done with those with
severe conditions, as they may be more willing to assume the risk of
something experimental.

One thing you might do is to check out the US govt site on clinical
trials. (clinicaltrials.gov). That may help you stay aware of what is
happening.

bob
dan@nospam.com - 22 Jan 2007 19:53 GMT
>>>> Hello,
>>>>
[quoted text clipped - 37 lines]
>
> bob

I know most of the medical stem cell research is moving out of the USA
(to SE Asia?).  Are there other websites to keep track of the whole world?

Dan
Bob - 24 Jan 2007 03:21 GMT
>> One thing you might do is to check out the US govt site on clinical
>> trials. (clinicaltrials.gov). That may help you stay aware of what is
[quoted text clipped - 4 lines]
>I know most of the medical stem cell research is moving out of the USA
>(to SE Asia?).  Are there other websites to keep track of the whole world?

Perhaps.

But the US site may contain more than you might expect. It lists
anything that involves the NIH at all -- even if the work is done
overseas. In fact, if you look at the "advanced search" page, you will
find a box to select the country in which the trial is being done.

Remember, only one type of stem cell research is actually restricted
in the US -- that on embryonic stem cells (ESC). I do not know if any
ESC trials are in progress elsewhere.

If you google on something like
clinical trials databases Europe
You will get hits. I didn't try to sort them out. If you find
something good, let us know. (There is much interest in making
information about clinical trials more public, so such databases
should become more common and accessible.)

bob
 
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