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Medical Forum / General / General / January 2007

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Neurology MRI report question

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Camilla Cracchiolo - 03 Jan 2007 11:04 GMT
Help.  My husband, 53 y.o. had the following report on an MRI,
following up a slightly abnormal EEG and one incident of temporary
altered mental status that soon resolved.  He has a history of Hep C:

"Lateral ventricles and cerebral sulci are prominent consistent with
atrophy.  There are multiple, small, high signal intensity foci
scattered about the centrum semiovale regions bilaterally, consistent
with microvascular ischemic changes. No other abnormal high or low
signal intensities are identified in the cerebral or cerebellar
hemispheres.  There is no evidence of acute intracranial hemorrhage,
mass effect, midline shift or hydrocephalus.  No signal abnormalities
are identified on diffusion weighted images.  No gross abnormalities
of the paranasal sinuses, mastoid air cells, orbits, sella and
suprasellar regions."

Impression:

1. atrophy.  

2.  Microvascular ischemic disease scattered in the centrum semiovale
regions bilaterally.

3.  Moderate deviation of the nasal septum from left to right."

The stuff I'm googling looks fairly alarming.  Any idea what this
means?  Not looking for a diagnosis, just to be informed when talking
to our neurologist and maybe ideas for a plan of action.

Thanks.
___________________________________________________              

             Camilla Cracchiolo
              Registered Nurse
            Los Angeles, California

camilla4@mindspring.com     webpage temporarily down
TheAmazingGuffy@gmail.com - 03 Jan 2007 15:04 GMT
> Help.  My husband, 53 y.o. had the following report on an MRI,
> following up a slightly abnormal EEG and one incident of temporary
[quoted text clipped - 14 lines]
>
> 1. atrophy.

This one is worrisome. With a history of Hep. C it could be
hyperammonaemia( the liver isn't removing enough ammonia from the
body)...Are his lever functions regularly checked?
http://www.nurseminerva.co.uk/metaboli1.htm

Also it isn't stated as to what degree the atrophy has progressed to
and cerebral atrophy is common in aging.

> 2.  Microvascular ischemic disease scattered in the centrum semiovale
> regions bilaterally.

This is usually caused by high blood pressure,hardening of the arteries
or Diabetes.

> 3.  Moderate deviation of the nasal septum from left to right."

I didn't see this on the report you posted. But it's estimated by some
that between 70 and 80% of all peoples nasal septums are deviated to
some degree. This ,most likely, is a condition he's had all of his
life.

> The stuff I'm googling looks fairly alarming.  Any idea what this
> means?  Not looking for a diagnosis, just to be informed when talking
[quoted text clipped - 8 lines]
>
> camilla4@mindspring.com     webpage temporarily down

This is all conjecture though....

hope it helps...
Camilla Cracchiolo - 05 Jan 2007 23:45 GMT
>> Impression:
>>
[quoted text clipped - 4 lines]
>body)...Are his lever functions regularly checked?
>http://www.nurseminerva.co.uk/metaboli1.htm

Yes, his liver enzymes are fine.  Last biopsy was a few years ago,
stage II fibrosis.  Could Hep C dementia show this?  Would this be
from Alzheimer's?  On Google, it suggests that high intensity foci in
this area are associated with Parkinson's and M.S.  

We got the MRI because he had one episode where he was at the dentist
and got completely disoriented.  The doc we saw thought it might have
been a reaction to lidocaine injection, since, in his experience,
sometimes lidocaine injected in the back of the mouth can hit nerves
that go to the higher nerve functions.  I don't know...maybe the doc
was trying to be reassuring.  He's also got some kind of genetic
learning disability affecting spatial perception and math and he's
always had a bad memory, but this was the first time he had altered
mental status.  He also is a long recovering (25 years) alcoholic and
methamphetatmine addict and did get into some fights which might have
caused head injury.  Could any of this be genetic?  Could any of it be
the "wreckage of his past" as he puts it?

Thanks for replying.  I'm really worried about him.

>Also it isn't stated as to what degree the atrophy has progressed to
>and cerebral atrophy is common in aging.

What you see is what I've got.  I imagine we'll have to have another
MRI in 6 months or a year to see how or if it's progressing.

>> 2.  Microvascular ischemic disease scattered in the centrum semiovale
>> regions bilaterally.
[quoted text clipped - 25 lines]
>
>hope it helps...
___________________________________________________              

             Camilla Cracchiolo
              Registered Nurse
            Los Angeles, California

camilla4@mindspring.com     webpage temporarily down
TheAmazingGuffy@gmail.com - 06 Jan 2007 19:04 GMT
> Yes, his liver enzymes are fine.  Last biopsy was a few years ago,
> stage II fibrosis.  Could Hep C dementia show this?  Would this be
[quoted text clipped - 21 lines]
> What you see is what I've got.  I imagine we'll have to have another
> MRI in 6 months or a year to see how or if it's progressing.

With a 25 years history of drug and alcohol abuse, there is a
possibility that he has had episodes like that before and not know
about it or been drunk or high when it has happened.

It is possible that it is genetic or history related. You need more
information...

Unfortunately the only thing you can really do is get the MRI examined
by a professional, and wait....
Camilla Cracchiolo - 05 Jan 2007 23:51 GMT
One other question:  what exactly does the centrum semiovale do?  

I can see it's smack in the middle of the brain.  The pictures look
like it's right above the brain stem and thalamus, and connects in
both hemispheres.  It looks behind and down from the frontal lobe, UT
above amydala and thalamus. One site said that motor functions were in
front and sensory connections behind.

Thanks.

>> Help.  My husband, 53 y.o. had the following report on an MRI,
>> following up a slightly abnormal EEG and one incident of temporary
[quoted text clipped - 52 lines]
>
>hope it helps...
___________________________________________________              

             Camilla Cracchiolo
              Registered Nurse
            Los Angeles, California

camilla4@mindspring.com     webpage temporarily down
TheAmazingGuffy@gmail.com - 06 Jan 2007 19:10 GMT
> One other question:  what exactly does the centrum semiovale do?
>
[quoted text clipped - 5 lines]
>
> Thanks.

The centrum semiovale conveys neural impulses through out the cerebrum.
It allows for communication within the same hemisphere.
 
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