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Medical Forum / General / General / November 2006Apoptosis?
Hello? "In biology, apoptosis (from the Greek words apo = from and ptosis = falling, commonly pronounced ap-a-tow'-sis[1]) is one of the main types of programmed cell death (PCD). As such, it is a process of deliberate life relinquishment by a cell in a multicellular organism. In contrast to necrosis, which is a form of cell death that results from acute cellular injury, apoptosis is carried out in an ordered process that generally confers advantages during an organism's life cycle. . Cell damage or infection Apoptosis can occur, for instance, when a cell is damaged beyond repair, or infected with a virus. The "decision" for apoptosis can come from the cell itself, from its surrounding tissue or from a cell that is part of the immune system. If a cell's capability of apoptosis is damaged (for example, by mutation), or if the initiation of apoptosis is blocked (by a virus), a damaged cell can continue dividing without restrictions, developing into cancer. http://en.wikipedia.org/wiki/Apoptosis " Apoptosis is said to be programmed cells death or somewhat "cells sucide".Apoptosis or sucide may not be natual phenomena and may oppose survival. How it is correct to use word "Apoptosis" for this purpose? Instead, can't it be natural or unnatural death or killing by body's mechanisms? Best wishes. >Hello? Can we expect that you will soon sign your name with a question mark ?? >"In biology, apoptosis (from the Greek words apo = from and ptosis = >falling, commonly pronounced ap-a-tow'-sis[1]) is one of the main types [quoted text clipped - 18 lines] >sucide".Apoptosis or sucide may not be natual phenomena and may oppose >survival. Apoptosis is a normal part of development. A simple example in humans is that you have fingers -- because the tissue between them (webbing) is eliminated by apoptosis, as a normal part of human development. This was first made clear, I suspect, by studying development -- cell by cell -- in the worm Caenorhabditis elegans. In addition to that role in normal development, apoptosis protects the organism by getting rid of damaged cells. The signaling processes for this are somewhat worked out -- an area of very active work. bob > >Hello? > > Can we expect that you will soon sign your name with a question mark > ?? Q&A can be two sides of discussions alike two sides of coin. > >"In biology, apoptosis (from the Greek words apo = from and ptosis = > >falling, commonly pronounced ap-a-tow'-sis[1]) is one of the main types [quoted text clipped - 31 lines] > > bob Why it is called/thought or found as Apoptosis instead of natural,unnatural death or killing by body systems? >> Apoptosis is a normal part of development. A simple example in humans >> is that you have fingers -- because the tissue between them (webbing) [quoted text clipped - 11 lines] >Why it is called/thought or found as Apoptosis instead of >natural,unnatural death or killing by body systems? I have no idea. But don't worry much about names. Names are often developed/assigned before something is fully understood. A name is a label, and not an explanation -- even if someone might have once intended it to be explanatory. A key point when the process first became evident was to distinguish it from simple messy death -- what is now usually called necrotic death. Apoptosis is a "clean" process; whatever the trigger, the organism undertakes an active process to eliminate a cell it no longer wants, and cleanly. Programmed cell death is certainly a good description of one role of apoptosis. Suicide is also a good description (at least in some sense), in that the cell kills itself, rather than being killed by an invader (= murder, I suppose). bob > >> Apoptosis is a normal part of development. A simple example in humans > >> is that you have fingers -- because the tissue between them (webbing) [quoted text clipped - 29 lines] > > bob It not the name but definition also indicate it as suicide;" is one of the main types of programmed cell death (PCD). As such, it is a process of *deliberate life relinquishment by a cell in a multicellular organism.* In contrast to necrosis, which is a form of cell death" Programmed cell death can be consider as natural death, necrosis/by injury as unnatural death, phagocytosis or otherwise killing by body's mechanism will be just "killing". But how it can be suicide, looks bit confusing. How can we measure for sure it is suicide not natural or unnatural death or killing? > > >> Apoptosis is a normal part of development. A simple example in humans > > >> is that you have fingers -- because the tissue between them (webbing) [quoted text clipped - 43 lines] > confusing. How can we measure for sure it is suicide not natural or > unnatural death or killing? To add furthur; "Programmed Cell Death Occurs through Apoptosis The demise of cells by programmed cell death is marked by a well-defined sequence of morphological changes, collectively referred to as apoptosis, a Greek word that means "dropping off" or "falling off" as in leaves from a tree. Dying cells shrink and condense and then fragment, releasing small membrane-bound apoptotic bodies, which generally are phagocytosed by other cells (Figure 23-45). Importantly, the intracellular constituents are not released into the extracellular milieu where they might have deleterious effects on neighboring cells. The highly stereotyped changes accompanying apoptosis suggested to early workers that this type of cell death was under the control of a strict cellular program. In contrast, cells that die in response to tissue damage exhibit very different morphological changes. Typically, cells that undergo this process, called necrosis, swell and burst, releasing their intracellular contents, which can damage surrounding cells and frequently cause inflammation. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.section.6889 " Should there be natural death somewhat alike ""dropping off" or "falling off" as in leaves from a tree when riped/matured or as riped fruits fall off? |
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