Hello

The current theory regarding the causes of male pattern baldness, MPB has
the main culprit as the hormone dihydrotestosterone, DHT. This is produced
locally in scalp hair follicle cells by the enzyme 5-alpha reductase which
produces it from testosterone. DHT has a much stronger affinity to the
androgen receptors on hair cells. It attaches to the receptor and this
complex enters the cell nucleus and affects gene expression which over time
turns the follicle from one producing terminal hair, to vellus hair. The
actual details of this process are not understood.



Now what I would like to know is this, is MPB caused by either:

1)      An overproduction of DHT balding men. i.e.  bald men have a much
higher conversion of DHT than non bald.

2)      Or a greater sensitivity of the follicle cells to DHT. So bald and
non bald have the same levels of DHT but the bald men have maybe more
receptors, more sensitive receptors etc or some other as yet unknown
difference that causes the balding process



Thanks.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Genes play a major role related to MPB.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~