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Medical Forum / General / General / July 2006Cancer drug versus natural substances
<<snip>> Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), may have similar chemotherapeutic effects on cancer cells as 5-fluorouracil (5-FU), <<snip>> Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells. Norwood AA, Tan M, May M, Tucci M, Benghuzzi H Biomed Sci Instrum. 2006; 42: 350-6 Antioxidants have been found to be quite successful in deterring certain disease processes for years, especially cancer. Antioxidants protect the body by neutralizing the free radicals and donating one of their own electrons, thus ending the scavenger reaction. Epigallocatechin-3-gallate (EGCG), the most abundant catechin found in green tea, is a valuable scavenger of reactive oxygen species in vitro as well as in vivo. Thymoquinone (TQ), a major active component of black seed (Nigella sativa), is also known for its powerful scavenger abilities as an inhibitor of oxidative stress and has been utilized in the Middle East for centuries for healing properties. These two potent antioxidants when compared to the chemotherapeutic drug of choice, 5-fluorouracil (5-FU), have demonstrated incredible chemotherapeutic responses to the SW-626 cell line. The objective of this study was to evaluate and compare the effects of SW-626 colon cancer cells after a 24, 48, and 72 hour incubation periods with low, medium, and high doses of EGCG, TQ, and 5-FU. Cell viability, cell number, cellular morphology, and cellular metabolism were compared for the control and treatment groups. The results of this study evidenced a similar significant decrease in cell number as early as 24 hours in the groups treated with TQ and EGCG compared to 5-FU. Increases in cellular damage were evident after 24, 48, and 72 hours and in all treated groups compared with the control. Reduced cell numbers in the treated groups suggests the possibility that TQ and EGCG may have similar chemotherapeutic effects on cancer cells as 5-FU. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > <<snip>> > Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), may have similar [quoted text clipped - 30 lines] > suggests the possibility that TQ and EGCG may have similar > chemotherapeutic effects on cancer cells as 5-FU. Don't run out and buy this stuff unless you are really desperate. It is virtually meaningless research. I wonder who is financing it? Everything is toxic to cancer cells in tissue culture and you can make any agent work or not work by simply changing its concentration (note no mention of what concentrations were used). . Also most colon cancer cell lines do NOT respond to 5 fluorouracil. It is not the "agent of choice" for colon cancer nowadays. Also high doses of antioxidants such as vitamin C have been well-tried with cancer, both in conventional and alternative circles and they have no noticeable effect. It is possible that high doses of intravenous antioxidants may have a useful anti-cancer effect because of their pro-oxidant activity in very high concentrations, but the track record of intravenous vitamin C is so far not very impressive. Peter Moran > > <<snip>> > > Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), may have similar > > chemotherapeutic effects on cancer cells as 5-fluorouracil (5-FU), > > <<snip>> > Also high doses of antioxidants such as vitamin C have been well-tried with > cancer,. > > Peter Moran Do you think there is a .. key .. 'difference' .. between the anti-oxidant .. vitamin C and the anti-oxidants .. Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), .. ? Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), .. chelate / bind up .. iron .. whereas .. ascorbate isn't all that .. good .. as an iron chelator .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >> > <<snip>> >> > Epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), may have similar [quoted text clipped - 14 lines] > up .. iron .. whereas .. ascorbate isn't all that .. good .. as an iron > chelator .. ? Many patients with cancer become severely iron deficient, in fact some kinds of cancer often declare their presence only as severe iron deficiency anemia without halting the progress of the cancer. Why, then, would you think the ability of a drug to chelate iron would confer on it the ability to attack cancer? Peter Moran > Who loves ya. > Tom [quoted text clipped - 7 lines] > DEAD PEOPLE WALKING > http://tinyurl.com/zk9fk > Many patients with cancer become severely iron deficient, in fact some kinds > of cancer often declare their presence only as severe iron deficiency anemia > without halting the progress of the cancer. Why, then, would you think > the ability of a drug to chelate iron would confer on it the ability to > attack cancer? Encased by the chelator, the iron is no longer available to perform its role in vital jobs. like transporting oxygen, and the cancer cell dies. > Peter Moran > > [quoted text clipped - 9 lines] > > DEAD PEOPLE WALKING > > http://tinyurl.com/zk9fk |
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