 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / General / General / June 2006AUTOIMMUNITY
This article speaks to the thesis .. radiation induced damage seems to be .. particularily .. coincidentally .. MIMICING .. the damage one finds in .. AUTOIMMUNITY. Since the active .. mode of operation .. OF cancer therapy is the INDUCTION of massive amounts of free radicals / reative oxygen species / rust / oxidative stress .. the researchers propose .. 'autoimmunity' .. is .. CAUSED .. by .. free radicals / reative oxygen species / rust / oxidative stress Free radical theory of autoimmunity. Kannan S Theor Biol Med Model. 2006 Jun 7; 3(1): 22 ABSTRACT: BACKGROUND: Despite great advances in clinical oncology, the molecular mechanisms underlying the failure of chemotherapeutic intervention in treating lymphoproliferative and related disorders are not well understood. Hypothesis: A hypothetical scheme to explain the damage induced by chemotherapy and associated chronic oxidative stress is proposed on the basis of published literature, experimental data and anecdotal observations. Brief accounts of multidrug resistance, lymphoid malignancy, the cellular and molecular basis of autoimmunity and chronic oxidative stress are assembled to form a basis for the hypothesis and to indicate the likelihood that it is valid in vivo. CONCLUSIONS: The argument set forward in this article suggests a possible mechanism for the development of autoimmunity. According to this view, the various sorts of damage induced by chemotherapy have a role in the pattern of drug resistance, which is associated with the initiation of autoimmunity. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Please read more closely what you post. It was about auto immunity from use of chemo in cancer treatment, not radiation as you suggested. There are many things that can be prooxidant, in this case the drugs used in cancer treatment. Using info from another recent post of your's, free iron to "rust" is not common because it is in a bound state. > Please read more closely what you post. It was about auto immunity from > use of chemo in cancer treatment, not radiation as you suggested. There > are many things that can be prooxidant, in this case the drugs used in > cancer treatment. Using info from another recent post of your's, free > iron to "rust" is not common because it is in a bound state >free iron to "rust" is not common Contrary .. it .. seems to what you .. 'say' .. since one in three is supposed to manifest .. diabetes .. the FACT that ALL diabetics have free floating iron .. means your .. calculations .. are .. obviously .. wanting .. That happens when your stupidity is not kept in .. check .. RESULTS: NTBI (non-transferrin-bound iron ) was commonly present in diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes Diabetes Care. 2006 May;29(5):1090-5. Related Articles, Links Common presence of non-transferrin-bound iron among patients with type 2 diabetes. Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song K, Lee IK, Kim B, Hider RC. Department of Preventive Medicine, School of Medicine, Kyungpook University, 101 Dongin-dong, Jung-gu, Daegu, Korea 700-422. lee...@knu.ac.kr. OBJECTIVE: Recently, we reported increased cardiovascular disease mortality among supplemental vitamin C users with type 2 diabetes in a prospective cohort study. Because vitamin C may cause oxidative stress in the presence of redox active iron, we hypothesized that non-transferrin-bound iron (NTBI), a form of iron susceptible to redox activity, may be present in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: We measured serum NTBI levels using high-performance liquid chromatography in 48 patients with known diabetes (at least 5 years duration since diagnosis), 49 patients with newly diagnosed diabetes, and 47 healthy control subjects (frequency matched on age and sex). RESULTS: NTBI was commonly present in diabetes: 59% in newly diagnosed diabetes and 92% in advanced diabetes. Mean NTBI values varied significantly between the three groups, with the highest values being observed in patients with known diabetes and the lowest in the control subjects (0.62 +/- 0.43 vs. 0.24 +/- 0.29 vs. 0.04 +/- 0.13 mumol/l Fe). Serum total iron or percent transferrin saturation were very similar among the three groups, yet NTBI was strongly associated with serum total iron (r = 0.74, P < 0.01) and percent transferrin saturation (r = 0.70, P < 0.01) among the patients with known diabetes. CONCLUSIONS: Consistent with our hypothesis, these data demonstrate the common existence of NTBI in type 2 diabetic patients with a strong gradient with severity. Prospective cohort studies are required to clarify the clinical relevance of increased NTBI levels. PMID: 16644642 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk Don't change the subject, you confused radiation with chemo and drew a false conclusion. The example where unbound iron is not bound iron is silly, if it is not bound it is indeed unbound. Using info from one of your recent posts, normally iron is bound.. > Don't change the subject, you confused radiation with chemo and drew a > false conclusion. The example where unbound iron is not bound iron is > silly, if it is not bound it is indeed unbound. Using info from one of > your recent posts, normally iron is bound.. <<snip>> Dioxin itself causes major oxidative stress <<snip>> Didn't you .. know .. that .. ? Heh .. heh .. Le Magazine, June 1999 - Cover Story: Safe And Effective Cancer ... Standard chemotherapy causes death to cancer cells by halting the cell cycle. ... Dioxin itself causes major oxidative stress. It has been characterized as ... www.lef.org/magazine/mag99/june99-cover.html - 64k - Cached - Similar pages Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk > Don't change the subject, you confused radiation with chemo and drew a > false conclusion. The example where unbound iron is not bound iron is > silly, if it is not bound it is indeed unbound. Using info from one of > your recent posts, normally iron is bound.. Whoops .. Chemotherapy-Associated Oxidative Stress: Impact on Chemotherapeutic Effectiveness Kenneth A. Conklin, MD, PhD Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, kconklin@mednet.ucla.edu Antineoplastic agents induce oxidative stress in biological systems. During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that can attack many cellular targets. These products of oxidative stress can slow cell cycle progression of cancer cells and cause cell cycle checkpoint arrest, effects that may interfere with the ability of anticancer drugs to kill cancer cells. The aldehydes may also inhibit drug-induced apoptosis (programmed cell death) by inactivating death receptors and inhibiting caspase activity. These effects would also diminish the efficacy of the treatment. The use of anti-oxidants during chemotherapy may enhance therapy by reducing the generation of oxidative stress-induced aldehydes. Key Words: antioxidants · apoptosis · chemotherapy · oxidative stress Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "Chemotherapy-Associated Oxidative Stress" Exactly, you said first it was radiation related, thanks for correcting yourself. |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.