Control of iron metabolism in Mycobacterium tuberculosis.
Rodriguez GM
Trends Microbiol. 2006 Jun 4;

Tuberculosis continues to kill millions of people around the world. New
tools to prevent and treat this disease are urgently needed. Similar to
most microorganisms, Mycobacterium tuberculosis - the causative agent
of tuberculosis - requires iron for essential metabolic pathways.
Because iron is not freely available in the host, pathogens must
actively compete for this metal to establish an infection but they must
also carefully control iron acquisition as excess free iron can be
extremely toxic. Recent studies have demonstrated that failure to
assemble the iron acquisition machinery or to repress iron uptake has
deleterious effects for M. tuberculosis. Here, we review how M.
tuberculosis obtains iron in a regulated manner and discuss how these
processes could potentially be disrupted to interfere with the survival
and replication of this bacterium in the host.

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