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Medical Forum / General / General / May 2006Iron content in brains
In vivo detection of iron and neuromelanin by transcranial sonography - a new approach for early detection of substantia nigra damage. Berg D J Neural Transm. 2006 May 18; In more than 90% of patients with idiopathic Parkinson's disease (PD) hyperechogenicity of the substantia nigra (SN) can be found by transcranial sonography (TCS) as a typical, stable sign. Animal experiments provided first evidence that SN hyperechogenicity may be associated with increased tissue iron levels. Two consecutive studies revealed the same association in human brain. Postmortem brains of 60 subjects without clinical signs for Parkinson's disease during life time at different ages were scanned by ultrasound with planimetric measurement of the echogenic area of the SN. Afterwards the SN was dissected and used for histological examination and determination of iron content in all brains as well as ferritin and neuromelanin content in 40 brains. A significant positive correlation was found between the echogenic area of the SN and the concentration of iron, H- and L-ferritins. A multivariate analysis performed considering the iron content showed a significant negative correlation between echogenicity and neuromelanin content of the SN. Iron staining confirmed the biochemical findings. In PD a typical loss of neuromelanin and increase of iron is observed in this brain area. However, it is not clear yet, whether iron accumulation is a primary cause or a secondary phenomenon in the disease process. Screening of genes involved in brain iron metabolism showed a significant association of some sequence variations of the ceruloplasmin gene with PD. Others were associated with the ultrasound marker for increased iron levels in both PD patients and control subjects. As SN hyperechogenicity is typical for PD or subjects with a preclinical impairment of the nigrostriatal system, these findings indicate that TCS enables the detection of increased iron and decreased neuromelanin levels at the SN, even before the clinical manifestation of PD. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk "However, it is not clear yet, whether iron accumulation is a primary cause or a secondary phenomenon in the disease process. " This is the case with most posts showing a correlation between any two things in biology, and if as this study clearly says, this statement should be mentally inserted into any study of this kind. Too often the dog and the tail are confused if this is not done. One can safely bet $1000 that oxyegen is also strongly correlated with both this condition studied and iron. Can we conclude that oxygen is the cause of the disorder and the iron? >>>>"However, it is not clear yet, whether iron accumulation is a primary cause or a secondary phenomenon in the disease process. " This is the case with most posts showing a correlation between any two things in biology, and if as this study clearly says, this statement should be mentally inserted into any study of this kind.<<<< No .. the .. take home message .. IS .. "iron in the brain is BAD" .. You somehow seem to forget this .. take home .. message .. Now .. why .. is .. that .. ? Because you are a fkg .. pussy .. Isn't that .. right .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>>>"However, it is not clear yet, whether iron accumulation is a primary cause or a secondary phenomenon in the disease process. " The above is the conclusion of the authors, the guess of a rank amateur is a dog that aint gonna hunt. Such amateurs should be seen for what they are so no damage is done by those reading such posts for the first time. >>>>> "However, it is not clear yet, whether iron accumulation is a >>>>> primary [quoted text clipped - 5 lines] > > No .. the .. take home message .. IS .. "iron in the brain is BAD" .. The take home message in *this* study is "iron in one part of the brain shows that something's not right". The only application this study might have is in diagnosing existing damage. The authors themselves say clearly that they have no idea whether in the SN iron is causing damage or is merely there as a result of damage that was caused by something else. The apple doesn't fall far from the tree, apparently. You're a raving loon, Tom... and unless you get some effective mental health treatment, you'll be a raving loon when you die - just like your dear old mom was. >>The authors themselves say clearly that they have no idea whether in the SN iron is causing damage or is merely there as a result of damage that was caused by something else.<< And the take home message IS .. "the iron IS in the brain and it is NOT .. supposed .. to .. BE .. !!!!!" What part of THAT don't you dildos .. understand .. ? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>> The authors themselves say clearly that they have no idea whether >>> in the SN [quoted text clipped - 6 lines] > > What part of THAT don't you dildos .. understand .. ? That part's perfectly understandable. It should also be understandable to *you* that when you hit your thumb with a hammer, blood (hence iron) ends up where it shouldn't be... but it's the hammer that causes the injury, and excess iron in the tissue is just a symptom of trauma. What *is* completely incomprehensible is your angry, filthy-mouthed gibberish when people take the time to explain your own posts to you. Michael, > What *is* completely incomprehensible is your angry, filthy-mouthed > gibberish when people take the time to explain your own posts to you. But you explained it yourself in your previous post: he IS a raving lunatic. Now that is also incomprehensible to me as well. Sylvia >>What *is* completely incomprehensible is your angry, filthy-mouthed gibberish when people take the time to explain your own posts to you. << Explain .. my posts to .. ME .. ? The article says .. iron in brain .. bad .. You .. people .. seem to have a problems with 'where' .. this .. BAD .. iron is ..coming .. from .. ? Leave it to those people who .. understand .. YOU .. and your cohorts .. would be well informed BY .. "iron in brain is bad .. " .. PREVIOUS work .. placed in the groups .. SPECIFICALLY speak to .. iron in the brain .. My posts are .. attacked .. On what .. grounds .. ? 'insert prancing little pussies .. here' .. "where oh where is all this iron coming from .. " .. Fk .. off .. Stay off my posts ... Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>>What *is* completely incomprehensible is your angry, filthy-mouthed > gibberish when people take the time to explain your own posts to you. [quoted text clipped - 3 lines] > > The article says .. iron in brain .. bad .. No. Learn to read, Tom. The article says... finding iron in the brain indicates by correlation that something bad has happened... in the same way that finding blood spurting from a limb indicates something bad has happened. Is the blood on the floor the problem, or is it the severed artery that should be examined and tended to? > You .. people .. seem to have a problems with 'where' .. this .. BAD .. > iron is ..coming .. from .. ? > > Leave it to those people who .. understand .. So, we can safely ignore *you*, then? > My posts are .. attacked .. > > On what .. grounds .. ? Their irrelevance to MS and your lack of understanding of what they say are certainly grounds enough - and your offensive approach to discourse about them cinches it - open and shut case, I'd say. > 'insert prancing little pussies .. here' .. "where oh where is all this > iron coming from .. " .. > > Fk .. off .. > > Stay off my posts ... Are you saying you're against freedom of speech, Tom? If you are, you should consider your own vulnerability in this regard. >>Are you saying you're against freedom of speech, Tom? If you are, you should consider your own vulnerability in this regard.<< So you've decided to .. step up .. have ya .. Sooo .. place your pussiness .. to one .. side .. Specifically .. WHAT .. about the above article .. "iron in the brain has been .. found !!!!!" .. So .. draws your .. ire .. Boi .. And make it fkg .. good .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>>Are you saying you're against freedom of speech, Tom? If you are, you > should consider your own vulnerability in this regard.<< > > So you've decided to .. step up .. have ya .. So, you've decided not to answer the question, have you? > Sooo .. place your pussiness .. to one .. side .. What about your evasiveness? Shouldn't that be dispensed with as well? > Specifically .. WHAT .. about the above article .. "iron in the brain > has been .. found !!!!!" .. Iron in the brain being found isn't anything new. What's new-ish is finding iron in people's brains without having to remove and process brain tissue. > So .. draws your .. ire .. There's nothing about the article that's drawn my ire, Tom. It's *you* who's done that. > Boi .. > > And make it fkg .. good .. Nothing's better than the truth. You should try it sometimes. >>It's *you* who's done that.<< So .. if .. I .. specifically .. place an article .. YOU get .. pissed .. Eh .. WHAT part of my description of .. YOU .. being .. a fkg .. pussy .. do you disagree with .. ? Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >>> It's *you* > who's done that.<< [quoted text clipped - 3 lines] > > Eh .. No. If you place an article in a newsgroup, you should be prepared to discuss it rationally, and you should have the decency to explain - if asked - exactly what it means. > WHAT part of my description of .. YOU .. being .. a fkg .. pussy .. > do you disagree with .. ? The fact that it's nothing but an unsupported attempt on your part to discredit me with slander is a good start. > So .. if .. I .. specifically .. place an article .. YOU get .. pissed > .. > Eh .. No. If you place an article in a newsgroup, you should be prepared to discuss it rationally, and you should have the decency to explain - if asked - exactly what it means. << Actually .. michael .. I don't think the above has .. ever .. been attempted with .. me .. It would be rather .. > WHAT part of my description of .. YOU .. being .. a fkg .. pussy .. > do you disagree with .. ? Actually ... the 'word' .. pussy .. has many .. 'meanings' .. It.. means .. "one who attacks without reason" .. or .. "uses underhanded tactics , lies .. falsifies .. etc .. DURING .. 'debate' / attack .." Somewhat like .. kicking a man when he is down .. Fkg .. pussy .. I think others would be able to think of their OWN .. run-ins WITH .. those who fit the description OF .. pussy .. YOU .. fit .. coincidentally .. both .. 'meanings' .. In the context of this thread .. I believe the 'meaning' of the word .. has been effectively .. proven .. And it .. seems .. admitted .. >>The fact that it's nothing but an unsupported attempt on your part to discredit me with slander is a good start.<< Heh .. heh .. You thought I called you a .. homo .. ? Heh .. heh .. No .. michael .. you are a .. pussy .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk >> So .. if .. I .. specifically .. place an article .. YOU get .. >> pissed .. [quoted text clipped - 8 lines] > Actually .. michael .. I don't think the above has .. ever .. been > attempted with .. me .. You may not "think" so, but it's happened many, many times. You ought to read back through the long history of our encounters. > It would be rather .. > [quoted text clipped - 5 lines] > underhanded tactics , lies .. falsifies .. etc .. DURING .. 'debate' / > attack .." Would you please show your readers a dictionary citation of these definitions? I've never seen or heard any such use of the term... anywhere. Besides, your unique definition above would describe *you* better than it describes me, Tom. While I do "attack" you now and then (not to evade or distract argument... simply because it can be fun to watch you melt down,) I usually offer you my opinions of the articles you post and ask you to explain yourself clearly - which you haven't done once yet in the entire decade of our interactions, choosing instead to attack without reason, use underhanded tactics, lie, falsify, ridicule and threaten. > You thought I called you a .. homo .. ? Not this time out, no... although you've done so many times in the past. Tom is mentally ill, and its just getting worse. Conversing with him is fruitless, he is ill. Logic and reason play no part in his mental process. Youre just antagonizing an ill person... Rob >>> So .. if .. I .. specifically .. place an article .. YOU get .. >>> pissed .. [quoted text clipped - 39 lines] > > Not this time out, no... although you've done so many times in the past. Tommy Tinpot wrote; <snip> > Actually ... the 'word' .. pussy .. has many .. 'meanings' .. > It.. means .. "one who attacks without reason" .. or .. "uses > underhanded tactics , lies .. falsifies .. etc .. DURING .. 'debate' / > attack .." > > Somewhat like .. kicking a man when he is down .. Not only does have his own religion and his own science, now he has his own language. I have never heard of this meaning for "pussy." In the dictionaries I've read, it means an affectionate term for a cat, vulgar slang for female sex organs, or it is a derogatory word for a coward, usually used on males. What dictionary are you using, Tommy? The one in your head with all the voices? Sylvia >Specifically .. WHAT .. about the above article .. "iron in the brain >has been .. found !!!!!" .. You would not win a Nobel prize on finding iron in the brain. Some would think, another child who has revealed something happens in brain |
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