Well, Rxlist isn't the end-all and be-all; it's just one tool. Apsirin
(and all salicylates) are NSAIDs, and NSAIDs are nephrotoxic to some
degree or another. Here's the "Precautions" section from the Physician's
Desk Reference for aspirin:

"Precautions:
General: Renal Failure: Avoid aspirin in patients with severe renal
failure (glomerular filtration rate less than 10 mL/minute).

Hepatic Insufficiency: Avoid aspirin in patients with severe hepatic
insufficiency.

Sodium Restricted Diets: Patients with sodium-retaining states, such as
congestive heart failure or renal failure, should avoid
sodium-containing buffered aspirin preparations because of their high
sodium content.

Laboratory Tests: Aspirin has been associated with elevated hepatic
enzymes, blood urea nitrogen and serum creatinine, hyperkalemia,
proteinuria, and prolonged bleeding time."

See the last section, on laboratory tests? Proteinuria (and increased
proteinuria) is one of the biggest dangers with NSAID use in kidney
patients.

I got the information from my internist and nephrologist, but here's
what the Physician's Desk Reference has to say on the subject:

"Renal Effects
As with other non-steroidal anti-inflammatory drugs, long-term
administration of sulindac to animals has resulted in renal papillary
necrosis and other abnormal renal pathology. In humans, there have been
reports of acute interstitial nephritis with hematuria, proteinuria, and
occasionally nephrotic syndrome.

A second form of renal toxicity has been seen in patients with prerenal
and renal conditions leading to a reduction in renal blood flow or blood
volume, where the renal prostaglandins have a supportive role in the
maintenance of renal perfusion. In these patients, administration of an
NSAID may cause a dose dependent reduction in prostaglandin formation
and may precipitate overt renal decompensation. CLINORIL may affect
renal function less than other NSAIDs in patients with chronic
glomerular renal disease (see CLINICAL PHARMACOLOGY ). Until these
observations are better understood and clarified, however, and because
renal adverse experiences have been reported with CLINORIL (see ADVERSE
REACTIONS ), caution should be exercised when administering the drug to
patients with conditions associated with increased risk of the effects
of non-steroidal anti-inflammatory drugs on renal function, such as
those with renal or hepatic dysfunction, diabetes mellitus, advanced
age, extracellular volume depletion from any cause, congestive heart
failure, septicemia, pyelonephritis, or concomitant use of any
nephrotoxic drug. Discontinuation of NSAID therapy is typically followed
by recovery to the pretreatment state."

http://www.drugs.com/pdr/clinoril_tablets.html

Yes, I have idiopathic FSGS. It usually effects older Black men with
high blood pressure, but I am a young(ish) white chick with very low
blood pressure. Go figger! My biopsy was unusual; in addition to the
FSGS, I was also found to have very early diabetic nephropathy and maybe
Minimal Change Disease as well. I now have extensive scarring, too, from
a chronic kidney infection. I also pass a lot of stones. In other words,
I have really busy kidneys.

To my knowledge, such a statement

I'm not sure how an opioid receptor antagonist would work for FSGS. I
can see how it might work for MS ... but I haven't read the studies yet,
just looked up what it is. Therapy with it would suck though - I take
narcotic analgesics!