High-dose Vitamin C As A Cancer Therapy

Main Category: Cancer/Oncology News
Article Date: 29 Mar 2006 - 6:00am (UK)

Although early clinical studies conducted by Linus Pauling showed that
high-dose vitamin C, given by intravenous and oral routes, may improve
symptoms and prolong life in patients with terminal cancer, no benefits
for cancer patients were seen when vitamin C therapy was administered
orally in double-blind placebo-controlled studies at the Mayo Clinic.
Since then, high doses of vitamin C have been used only as an
"alternative" therapy to standard cancer treatment. However, recent
evidence shows that intravenous administration of the maximum tolerated
dose of vitamin C produces plasma concentrations about 25 times higher
than when the vitamin is administered orally. At concentrations above
1000 mmol/L -- which can only be achieved by the intravenous route --
vitamin C is toxic to some cancer cells but not to normal cells in
vitro.

Padayatty and colleagues report on 3 well-documented cases of advanced
cancers, confirmed by histopathologic review, where patients had
unexpectedly long survival times after receiving high-dose intravenous
vitamin C therapy. They assessed the clinical details of each case in
accordance with National Cancer Institute (NCI) Best Case Series
guidelines, and found that the case reports indicate that the role of
high-dose intravenous vitamin C therapy in cancer treatment should be
reassessed.

###

p. 937 Intravenously administered vitamin C as cancer therapy: three
cases -- S.J. Padayatty et al

http://www.cmaj.ca/pressrelease/pg937.pdf

Contact: Marcia Vital
Canadian Medical Association Journal

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