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Medical Forum / General / General / March 2006Early-intervention therapies needed for Alzheimer's disease
Reseachers show that dendritic spine density, impaired long-term potentiation (LTP), and behavioral deficits occurred months before plaque deposition in the Tg2576 mouse model of Alzheimer's disease. The findings of this study highlight the importance that early-intervention therapies will have in the treatment of Alzheimer's disease. Jacobsen et al. (2006) Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0600948103. The question is: Where are those early-intervention therapies? ----------- Health Information http://click2health.webmedtoday.com Latest Medical Discoveries http://aims.webmedtoday.com >Reseachers show that dendritic spine density, impaired long-term >potentiation (LTP), and behavioral deficits occurred months before [quoted text clipped - 9 lines] > >The question is: Where are those early-intervention therapies? Let me rephrase the question -- What would those early-intervention therapies be? To name a few: DHA at about 1.5g per 1000Cal consumed. Purified EGCG at about 14mg/Kg(BW) per day in divided doses. Teavigo is purified EGCG. Curcumin at about a couple of hundred mg/day. R-lipoic acid at about 600mg/day in divided doses along with acetyl-l-carnitine at about 2 or 3 g/day in a divided dose. Ibuprofen appears to be among the best NSAIDs to slow Alzheimer's. It does have its dangers. At low doses it can cause stomach ulcers and at higher doses produce kidney and liver damage. NFT's occur years before overt AD in humans. A study in men aged 55-64 found ~75% of them had NFT's in parts of their brain. This may be when the prodromal period of the disease i.e., well before age 55. Ann Neurol. 1985 Mar;17(3):273-7. Related Articles, Links Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer's disease and senile dementia of Alzheimer type. Ulrich J. Senile plaques (SP) and neurofibrillary tangles (NFT) were found in 38 (74.5%) of 51 unselected brains of nondemented patients who died between the ages of 55 and 64 years. A high proportion (22, or 43%) had only NFTs. These were consistently present in the entorhinal cortex and/or the hippocampus; the olfactory bulb, the amygdala, and the nucleus basalis of Meynert were also occasionally involved. Isolated SPs were seen in only 3 brains (6%); SPs and NFTs coexisted in 13 (25.5%). The distribution patterns of NFTs and SPs differed. NFTs were seen in discrete, mostly single neurons of the structure, already noted, whereas SPs occurred in a more generalized distribution over the base and convexity of the cerebrum. The plaques were usually small (30 mu in diameter) and consisted of delicate fibrillary material. Other types of SP were also seen. The incidence of various types of plaques in nondemented patients is considered to indicate a morphological evolution of these structures. PMID: 3994315 [PubMed - indexed for MEDLINE] |
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