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Medical Forum / General / General / March 2006

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Flavonoids to be medicines for iron overload diseases

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ironjustice@aol.com - 11 Mar 2006 17:42 GMT
Eur J Pharmacol. 2006 Mar 6;
Zhang Y, Li H, Zhao Y, Gao Z

The introduction of new iron chelating drugs may ultimately improve
iron-chelation therapy for patients with iron overload diseases such as
thalassaemia and other disorders. In this paper, the in vivo effects of
baicalin and quercetin on iron overload induced liver injury were
studied on
mice. It was found that when iron-dextran induced iron overload mice
were
fed baicalin or quercetin containing diet (1% w/w) for 45days, both
flavonoids significantly inhibited iron overload induced lipid
peroxidation
and protein oxidation of liver, decreased hepatic iron and hepatic
collagen
content, increased the serum non-heme iron level but not serum ferritin
level. Flavonoids supplementation also increased the excretion of iron
through feces. In vitro study demonstrated that both flavonoids could
release iron from ferritin. These results indicate that besides acting
as
antioxidants, both flavonoids can also release iron from liver and
finally
excrete it through feces. The present study provides further support
for
flavonoids to be medicines for iron overload diseases.

Read more <">http://www.hubmed.org/display.cgi?uids=16527270>

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore

DEAD PEOPLE WALKING
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Twittering One - 11 Mar 2006 18:01 GMT
Too much Irony,
Too much Tyranny, no justice.
Michael - 11 Mar 2006 19:51 GMT
> Too much Irony,
> Too much Tyranny, no justice.

Abundant ferrous overburden
Abandon hope all ye who enter here
 
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