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Medical Forum / General / General / March 2006Iron (Fe) is essential for the proliferation of cancer cells
Anticancer Drug Des. 2001 Aug-Oct;16(4-5):195-207. Related Articles, Links The desferrithiocin (DFT) class of iron chelators: potential as antineoplastic agents. Kicic A, Chua AC, Baker E. Department of Physiology, University of Western Australia, Nedlands, Australia. Iron (Fe) is essential for the proliferation of cancer cells. A subgroup of the orthosubstituted phenolate class of Fe chelators, desferrithiocin [2-(3'-hydroxypyrid-2'-yl)4-methyl-delta2-thiazoline-4(S)-carboxylic acid; DFT] and its analogues, have potential application in short-term chemotherapy for cancer by Fe deprivation. Their effects on cell proliferation, cell cycle progression, Fe uptake and toxicity were therefore examined in adult and fetal rat and human hepatocellular carcinoma (HCC) cell lines, as well as in normal cells. DFT was more active than desferrioxamine, in clinical trials as an antineoplastic agent, consistently inhibiting cell proliferation in all cell lines (IC50 = 40 microM). 2-(2'-hydroxyphenyl-2'-yl)-delta2-thiazoline-4(S)-carboxylic acid was the most active analogue (IC50 = 55-90 microM). Inhibition was affected by chelator concentration and ability to prevent Fe uptake. The fetal-cell-derived HCC was more susceptible than adult HCC. Structure-activity studies revealed that thiazol methyl deletion greatly diminished antiproliferative activity of the chelators but stereochemical orientation of COOH around C4 had no effect. Removal of the N from the pyridine ring restored antiproliferative activity. Chelators inhibited DNA synthesis in the S phase. The chelators at their IC50 concentration had little or no effect on Fe uptake in normal cells. This apparent selectivity of these chelators for cancer cells, coupled with their high activity, suggests that further investigation is warranted. PMID: 12049478 [PubMed - indexed for MEDLINE] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking I have yet to fully figure out why you keep posting studies like this in a nutrition group. Are you saying that we should stop eating foods containing iron? If we go without iron, we get iron deficiency anemia. Let that go for too long and we die. Hemoglobin can not be produced without iron. Oxygen can not be distributed throughout the body without hemoglobin. So, what are you saying, man? Max. >>I have yet to fully figure out why you keep posting studies like this in a nutrition group. Are you saying that we should stop eating foods containing iron? If we go without iron, we get iron deficiency anemia. Let that go for too long and we die. Hemoglobin can not be produced without iron. Oxygen can not be distributed throughout the body without hemoglobin. So, what are you saying, man? Max. << You store seven months worth of iron .. There is no .. iron .. deficient .. people in the world .. Anyone who has food .. has .. iron .. The addition of iron to foods kills you .. The eating of meat .. a HIGHLY absorbable form of iron leads to iron toxicity .. elevated / abnormal levels of iron which .. oxidizes .. destroying .. antioxidants .. and while in this state of high elevation is FREE to be .. 'accessed' / used by .. pathogens .. bacteria .. fungi .. virus' and cancer cells for .. proliferation .. Any 'anemia' .. you EVER .. run into .. is NOT .. iron deficient anemia .. Low iron diet / reduced iron diet / iron restricted diet .. restricts .. infection .. Low iron diet is around 7ppm iron .. lacto-vegetarian diet / dairyvegetable .. diet .. That diet has been used to lower iron levels in hepatitis patients .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > Any 'anemia' .. you EVER .. run into .. is NOT .. iron deficient anemia Mrs X presented in haematology clinic with Hb 5.1 g/dl & MCV 72.1 fl. Prescribed oral ferrous sulphate. Six montyhs later Hb 11.3 g/l, MCV 82.3 fl. Not iron deficient? One lives & learns. Is your period key stuck? What's wrong with your keyboard? I'd love to see the evidence you have that shows there no such thing as iron deficiency anemia. Here's another definition for you: "Iron deficiency anemia is the most common form of anemia. Approximately 20% of women, 50% of pregnant women, and 3% of men are iron deficient. Iron is an essential component of hemoglobin, the oxygen-carrying pigment in the blood. Iron is normally obtained through the food in your diet and by recycling iron from old red blood cells. Without it, the blood cannot carry oxygen effectively -- and oxygen is needed for the normal functioning of every cell in the body." http://www.nlm.nih.gov/medlineplus/ency/article/000584.htm I'm about as open minded as they come. I've even been told that I'm open minded to a fault, but I'm sorry, unless you can post some credible references to your claims, I can't possibly take anything you've said seriously. Max. your fuckin gone man. go get a life rusty. > You store seven months worth of iron .. > [quoted text clipped - 32 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking >>I don't see them using any .. 'william lee' .. chelators in .. cancer ..<< Now WHY .. is .. that .. Because .. william lee .. is .. nobody .. William Lee is .. who .. ? One more ... time .. Nobody .. Heh .. heh Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >Low iron diet is around 7ppm iron .. lacto-vegetarian diet / >dairyvegetable .. diet .. Back to spinach greens, stinging nettle soup and parsley. Good for your health ironjustice :-) |
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