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Medical Forum / General / General / March 2006neutropenia, low wbc - causes??
Hi new to here - so hope this is the right place to post my request for help/info!! Over the last month or so, i've been feeling progressively more and more exhausted and tired etc. I then had a bout of nausea and vomiting about 4 weeks ago, which lasted a week. The nausea would not stop so i went to the docs, along with v bloated belly. He gave me some anti nausea stuff which worked a treat, and this has now reolved, but he decided to do a CBC anyway. I had previous cbc in oct and the only thing it showed was low ferritin, thus took iron for a month. ferritin in Nov was borderline normal low. Initial results came back highlighting neutropenia and low wbc, to be retested 2 weeks later. 1st results show - 2nd tests 2weeks later wbc - 3.4 - 3.9 HB - 14 - 12.5 plate - 200 - 204 RBC - 4.54 - 4.09 Haematocrit - 0.41 - 0.38 MCV - 90.7 - 92.9 mch - 30.8 - 30.6 mchc - 34 - 32.9 rbc WIDTH - 13% - 13.4 Neutrophils count - 1.3 - 1.6 Lympho - 1.5 - 1.7 Mono - 0.4 - 0.5 Eosin - 0.1 - 0.1 Baso - 0.1 - 0.0 My Gp has thus referrred me to a haematologist - but i can't get an appointment for three weeks, amd would appreciate any suggestions as to posisble causes, and if it could be related to my fatigue. Other sysmptoms - possibly unrelated - are - periodic severe night sweats (enough to drench sheets, but not hormonal nor TB), but no daytime temp (in fact base temp is around 36.4 normally, and i suffer from severe Raynauds disease). had chronic viral infection last autumn, during which an ECG showed up a right bundle branch block on the ECG requiring no action. I also suffer regualry from skin sores on my face, arms and back, and legs - rarely infected, but sore and red and often take ages to heal. Bit like acne but not. I also have achey hips and joints periodically, but was tested negative in 2004 for SLE/Lupus - so can't be that.Had flu jab annualy. BTW - i am a 35yr old white female, with history of depression (PTSD), migraine, PCOS - the only meds i am on is prozac - (whatever the lowest dose is) for last 2 yrs. Mother died aged 65 of idiopathic fibrosing alveoilitis. I'm aware of the fact that this could just be casued by a virus, or it could be more sinister - but would appreciate somebody elses views until i get to see the consultant in April. Many thanks in advance!! Merry > Hi > [quoted text clipped - 7 lines] > nausea stuff which worked a treat, and this has now reolved, but he > decided to do a CBC anyway. Viral infection? Did he check your liver or do chemistry testing? AST or ALT? Sedrate? CRP? I had previous cbc in oct and the only > thing it showed was low ferritin, thus took iron for a month. ferritin > in Nov was borderline normal low. [quoted text clipped - 20 lines] > > My Gp has thus referrred me to a haematologist - I take it by the spelling Hae that you are in UK or Canada? but i can't get an > appointment for three weeks, amd would appreciate any suggestions as to > posisble causes, and if it could be related to my fatigue. That would depend on the cause. http://www.neutropenia.ca/ > Other sysmptoms - possibly unrelated - are - periodic severe night > sweats (enough to drench sheets, but not hormonal nor TB), There are other infections and conditions that can do this including inflammatory autoimmune ones. but no > daytime temp (in fact base temp is around 36.4 normally, and i suffer > from severe Raynauds disease). Some connection needs to be ruled out here including lymphoma, felty's (Rheumatoid arthritis splenic involvment), cryoglobulinemia from hepatitis or autoimmune disease. had chronic viral infection last autumn, > during which an ECG showed up a right bundle branch block on the ECG > requiring no action. > > I also suffer regualry from skin sores on my face, arms and back, and > legs - rarely infected, but sore and red and often take ages to heal. Vasculitis? An ANCA serology test should be done. > Bit like acne but not. I also have achey hips and joints periodically, > but was tested negative in 2004 for SLE/Lupus - so can't be that.Had > flu jab annualy. I would redo an ANA, RA and sedrate. > BTW - i am a 35yr old white female, with history of depression (PTSD), > migraine, PCOS - the only meds i am on is prozac - (whatever the lowest [quoted text clipped - 4 lines] > could be more sinister - but would appreciate somebody elses views > until i get to see the consultant in April. The neutropenia its self is not that severe to cause symptoms. "The severity of neutropenia is categorized as mild with an ANC of 1000-1500 cells per mm3, moderate with an ANC of 500-1000 cells per mm3, and severe with an ANC of fewer than 500 cells per mm3. The risk of bacterial infection is related to the severity and duration of neutropenia." http://www.emedicine.com/med/topic1640.htm Your last count was not neutropenic at 1600. I wouldn't worry about the neutropenia per say but what is going on with your body involving fever, Raynauds,joint and skin involvment. The neutropenia is divided into acute and chronic and going into a hematologist might look at everything including medication. Neutropenia is not a diagnosis. > Many thanks in advance!! > > Merry |
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