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Medical Forum / General / General / February 2006

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Optimum T dosage and timing

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avillalo@nimax.com - 06 Feb 2006 20:12 GMT
Hello all,
I'm currently taking 200mg/day of T for hypogonadism (doctor
supervised) My levels are now great.(aroung 750-850, or "high normal",
as the doc says)   I'm currently taking 100mg at around 6:30 am and
100mg around 10-11pm -  The Doc thinks this is fine, but what of the
highly pulsatile nature of T production naturally, is
there anything to be gained, maybe lower overall dosage, maybe a more
"natural" flow, by taking smaller doses throughout the day?
I think the  "reference range"  (from LabCorp) is nearly useless-
Is it a  normal distribution?  How about percentile level for all
people my age? Too much to ask? Sheesh!

I'm looking for a pointer to alot more detail on any research done on
Human T production over a 24 hour period.   Is it 10 pulses of 10% ?
is it more like 20-30 pulses of a
few% each? Whats the delta between the biggest and smallest pulse.  Is
it even possible to measure this way?  Whats the relationship of plasma

T level to actual T production in ng/dl  (or whatever the units are)
Thats the kind of data I'm looking for- Is that kind of detail even
available online?

Thanks everyone!
Robert - 06 Feb 2006 21:28 GMT
> Hello all,
> I'm currently taking 200mg/day of T for hypogonadism (doctor
[quoted text clipped - 19 lines]
>
> Thanks everyone!

Details are open for interpretation which is what you are really after.
copyright infringement let me summarize.

Current controversies in testosterone testing: aging and obesity
Elin RJ, Winters SJ
Clinics in Laboratory Medicine - March 2004 (Vol. 24, Issue 1, Pages 119-139

Testosterone circulates in the plasma in the free form but also in bound to
protein carriers so the total testosterone may not be the ideal specimen.

Controversies exist about the accuracy and interpretation of clinical
laboratory tests to evaluate sex hormone production and function,
particularly in obese and elderly men for the problems you stated.

The ideal specimen is one collected in morning between 8 and 10.
A circadian rhythm exists where it is highest in the morning and some say
that is when other hormones are also high causing some heart attacks.

. The difference in the concentration between the lowest and the highest is
approximately 15%, but may be as much as 50%. The pulsatile frequency of
testosterone secretion about once per hour but the pulse amplitude is low
with small fluctuation in the blood concentration

The total testosterone concentration may be insufficient to appropriately
evaluate testosterone deficiency in certain clinical situations, such as
obesity and older men and also in men who have hyperinsulinemia or hyper- or
hypothyroidism and men who are on antiepileptic drugs. Like other serum
analytes that are protein bound, such as total calcium and total thyroxine,
the amount of the binding protein may effect the measurement of the total
concentration of the analyte; only the free analyte has biologic activity.
In men, approximately 44% to 65% of testosterone is bound to SHBG, a
high-affinity but low-capacity binding protein and about 33% to 50% is bound
primarily to albumin with a high capacity but low affinity. The total
testosterone concentration in plasma is related directly to the SHBG
concentration in men. Several factors affect the concentration of SHBG in
plasma and, thus, influence the total testosterone concentration. The bias
in the total testosterone concentration that is due to SHBG in certain
clinical situations supports the determination of the free testosterone or a
surrogate test/index.
Spanky - 07 Feb 2006 00:22 GMT
Great response-thanks!  my next step is to model that somehow (in
excel?)
By this quote:

"The difference in the concentration between the lowest and the highest
is
approximately 15%, but may be as much as 50%. The pulsatile frequency
of
testosterone secretion about once per hour but the pulse amplitude is
low
with small fluctuation in the blood concentration "

It would appear that more, smaller doses of supplemental T would be a
more natural way to administer it- Anyone disagree or have experience
with this dosage pattern?

Does anyone know the half-life of a supplemetal T dose in adult males?

MORE INFO on me:

Age 41
FItness- Excellent - Wt. 170lbs  Bodyfat<10%
no diseases or metabolic disorders other than naturally low T

Thanks  All!
 
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