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Medical Forum / General / General / January 2006

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Can anyone tell me normal TSH levels in infants

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injesus - 23 Jan 2006 21:46 GMT
I have Identical twin boys, one of whom tested boarderline for
hypothyroidism.  No levels were given, subsiquently 4 tsh and free t4
tests have been done on both of them, the one who tested boarder line,
testest 10.14 ml/UL and normal free t4 the other was in normal range
for both, the second test he went down to 9.0 and the other was still
normal, on the third he dropped to 8 and the other elevated to 7, both
have normal free t4.  now they stayed the same on the last test and
were going to see the pediatric endocranologist on Feb 8, they are 2
months old. I can't see to find what the normal levels are though,
and in the cases of congenital hypothyroidism I've found the levels
were significantlly higher than these and the t4 was really low.  I'm
not sure what to make of this, I can't seem to find much information
on newborns about this? btw, they are 2 months old now

Thanks
J

Posted via medical forums at http://medical.gr77.com
Robert - 23 Jan 2006 22:37 GMT
> I have Identical twin boys, one of whom tested boarderline for
> hypothyroidism.  No levels were given, subsiquently 4 tsh and free t4
[quoted text clipped - 14 lines]
>
> Posted via medical forums at http://medical.gr77.com

Don't really know about newborns or pediatric populations and we really
don't have normals on our reports.

For adults this is typical.

"TSH values greater than 20 mU/L, even in the absence of overt clinical
signs of hypothyroidism, mean primary hypothyroidism. Values less than that
and in particular less than 10 mU/L in asymptomatic patients are more
difficult to evaluate. It is important to become familiar with the reasons
for increases and decreases in serum TSH in the absence of thyroid
dysfunction. Nonthyroidal illnesses can account for both increases and
decreases."

Although the stated reference range for adults can be as high as 5 mU/L some
endocrinologists consider values greater than 3 as borderline.

The free T4 is important in trying to determine it's relationship to the
TSH. A decrease Free T4 would indicate primary hypothyroidism. A normal free
T4 would be borderline or Subclinical Hypothyroidism and an increase in free
T4 would indicate a TSH secreting tumor or thyroid hormone resistance.

Although not in play with identical twins, fraternal twins have been known
to exhibit chimerism of tissue sharing. They may contain DNA from two
individuals within one person.
Although strictly conjecture, hypothyroidism and fetal-maternal chimera has
been postulated as a cause for autoimmune hypothyroidism.
 
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