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Medical Forum / General / General / December 2005Luprone, a prostate cancer drug found affective on Alzheimers
Heard on the news tonight that a patient who had Alzheimers and contracted prostate cancer was given Luprone for the cancer but it seemed to halt the Alzheimers also. So I was searching on the web as to the chemical formula of Luprone. Anyone know? And anyone offer a explanation as to how it may work on Alzheimers? If my memory serves me, I last left off on Alzheimers as a family of diseases where Parkinson and Prion were similar diseases and that since Parkinsons is caused by well-water bacteria that a microbe is the cause also of Prion and Alzheimers. So if Luprone is effective on Alzheimers, does luprone somehow kill or get rid of cancer cells? And if it does kill cancer cells, does it kill bacteria or other microbes? Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies Now as far as I can see that this Lupron is Leuprolide Acetate which really does not tell me much about its chemistry. If my theory is correct that the Family Diseases of Alzheimers, Parkinsons and Prion if so related that a cure in one would be a cure in all. I suppose Lupron is not a cure for Alzheimers but halts or slows down the process. And in Parkinsons the cause is microbes in well-water such as bacteria. So the cause in Alzheimers and prion would also be microbes. >From what I gather about Lupron is that it is related to hormones. Is that true? Anyway, if it halts or slows down Alzheimers, then Lupron should also be effective against both Prion and Parkinsons. So has anyone contracted Prion or Parkinsons and then contracted prostate cancer? So for the person who found out he/she had both Alzheimers and prostate cancer and took Lupron and was surprized to find Alzheimers abated, is there another person out there who has both Prion and prostate cancer and both Parkinsons and prostate cancer so that we can find out if Lupron mitigates not only Alzheimers but also Prion and Parkinsons. If Lupron is a cure, I suspect the way it works is not to kill the microbe that causes Alzheimers, Prion or Parkinsons, but rather what the microbe does is start the body to install a rogue protein assembly factory in the body and where the Lupron halts the disease is that it somehow jams the protein production gone awry in the body. Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies >Heard on the news tonight that a patient who had Alzheimers and >contracted prostate cancer was given Luprone for the cancer but it >seemed to halt the Alzheimers also. > >So I was searching on the web as to the chemical formula of Luprone. >Anyone know? It is an anti-androgen (reduces production of testosterone). Growth of some prostate tumors is dependent on (stimulated by) testosterone, so depriving them of the hormone reduces the growth (for a while, until the tumor becomes hormone-independent). It is chemical castration. (And I vaguely recall it is indeed the drug used for chemical castration of sex offenders.) I would doubt that it has any general action on cancer cells or on any microbes. You can check Medline to see if anything has been reported. But its action here is not to kill cancer cells, but to slow this special type. >And anyone offer a explanation as to how it may work on >Alzheimers? Well, that would be sheer speculation at this point. The first question is whether the observation pans out as significant. Sometimes an anecdotal observation, when followed up, turns out to lead to something. Often it does not. If it holds, one can worry later about mechanism. I think it is known that sex hormones affect the brain, so there is no reason to suggest that it can't be true. Whether it acts in some general way on the brain ("stimulating" it), or acts in some way directly relevant to Alz, is completely open. bob It is an anti-androgen (reduces production of testosterone). Growth of some prostate tumors is dependent on (stimulated by) testosterone, so depriving them of the hormone reduces the growth (for a while, until the tumor becomes hormone-independent). It is chemical castration. (And I vaguely recall it is indeed the drug used for chemical castration of sex offenders.) I would doubt that it has any general action on cancer cells or on any microbes. You can check Medline to see if anything has been reported. But its action here is not to kill cancer cells, but to slow this special type. >And anyone offer a explanation as to how it may work on >Alzheimers? Well, that would be sheer speculation at this point. The first question is whether the observation pans out as significant. Sometimes an anecdotal observation, when followed up, turns out to lead to something. Often it does not. If it holds, one can worry later about mechanism. I think it is known that sex hormones affect the brain, so there is no reason to suggest that it can't be true. Whether it acts in some general way on the brain ("stimulating" it), or acts in some way directly relevant to Alz, is completely open. bob A.P. writes: Very interesting. According to Alzheimers, Prion and Parkinsons they all involve some rogue protein. Do hormones affect mainly proteins in the body? And is there a disease that is common involving too much testosterone which affects a protein and for which it was not recognized that the disease belonged in the same family of disease of Alzheimers Prion and Parkinsons. Now I wonder if Autism belongs in the same family of disease as Alzheimers Prion and Parkinsons where a hormone imbalance leads to a protein gone awry and thus Autism. Where Autism is sort of the young age of Alzheimers and Alzheimers a sort of old age Autism. In Autism is there a protein gone awry? And I wonder if there is a case of a human who has autism and prostate cancer and if Lupron treatment alleviates the autism. Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies The important issue here is that Alzheimers, Prion and Parkinsons are members of a Family Related Disease. If a microbe is found to be the cause in one of them, such as bacteria in well-water was found to cause Parkinsons, then a microbe is the cause in Alzheimers and Prion. If a protein gone awry is the mechanism in one of those diseases, then a protein gone awry is the mechanism in the other two diseases. This is what it means to be a Family Related Group of Diseases. What is found true in one has a resemblence in the other two. So we found a microbe as the cause of Parkinsons implies that a microbe is the likely cause of both Alzheimers and Prion. Now we found that Lupron ameliorates the Alzheimers disease and if true then the implications are that Lupron will ameliorate Parkinsons and Prion (CJD). And I wonder if there are more diseases that belong within this Family Related Group. I wonder if Autism is a member of this group. I wonder if a protein mechanism has gone awry. I wonder if it is concentrated in the brain region for which Alzheimers, Parkinsons and Prion are. So as Bob tells me that Lupron is a hormone inhibitor, how does that affect protein assimilation in the brain? Can someone tell me if Alzheimers Parkinsons and Prion seem to favor males over females and whether Autism favors males over females. Now I know hormones are both in male and female but perhaps these diseases favor one hormone over the other. How does a microbe involve itself? It maybe that a microbe is involved in setting up a allergic reaction for whence the body thereafter switches on a deformation of protein synthesis. Complex diseases have multifactors to bring on the onset of the disease. Archimedes Plutonium www.iw.net/~a_plutonium whole entire Universe is just one big atom where dots of the electron-dot-cloud are galaxies |
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