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Medical Forum / General / General / December 2005Aspartame Causes Cancer in Rats
ARTIFICIAL SWEETENER ASPARTAME CAUSES CANCER IN RATS Scientists are calling for an urgent reevaluation of the artificial sweetener aspartame. The ingredient, commonly found in sugar-free beverages and candies, has been shown to cause cancer in rats, according to a new study in the peer-reviewed journal Environmental Health Perspectives. "Our study has shown that aspartame is a multi-potential carcinogenic compound whose carcinogenic effects are also evident at a daily dose of 20 milligrams per kilogram of body weight (mg/kg), notably less than the current acceptable daily intake for humans," the authors write. http://www.organicconsumers.org/foodsafety/aspartame112805.cfm > ARTIFICIAL SWEETENER ASPARTAME CAUSES CANCER IN RATS > Scientists are calling for an urgent reevaluation of the artificial [quoted text clipped - 7 lines] > for humans," the authors write. > http://www.organicconsumers.org/foodsafety/aspartame112805.cfm I'm glad that only a few people consider me to be a rat > ARTIFICIAL SWEETENER ASPARTAME CAUSES CANCER IN RATS > Scientists are calling for an urgent reevaluation of the artificial [quoted text clipped - 7 lines] > for humans," the authors write. > http://www.organicconsumers.org/foodsafety/aspartame112805.cfm A check on www.pubmed.gov with the search words "ASPARTAME cancer" came up with a total of 31 journal entries (papers, reviews, letters, editorials, etc). The most recent one was in Oct. of 2004. It is one where it is free to see the entire article: http://annonc.oxfordjournals.org/cgi/content/full/15/10/1460 The conclusion that was in the abstract was this: "However, according to the current literature, the possible risk of artificial sweeteners to induce cancer seems to be negligible." So the above referenced website seems to have resorted to lying. It would not be the first time. Like one of their more recent scare stories: http://www.snopes.com/toxins/cheers.asp Remember, when a squaremonger gives you a line about something... just remember to check out medical literature at www.pubmed.gov ... and it is always good to check out the Urban Legends webpage at www.snopes.com, which just so happens to have a page on aspartame: http://www.snopes.com/toxins/aspartame.asp > > ARTIFICIAL SWEETENER ASPARTAME CAUSES CANCER IN RATS > > Scientists are calling for an urgent reevaluation of the artificial [quoted text clipped - 13 lines] > to see the entire article: > http://annonc.oxfordjournals.org/cgi/content/full/15/10/1460 This is irrelevant to the veracity of the organicconsumers info. The new nih study may be in process to pubmed listing (it was just epub'ed nov 17) or it may never make it, in either case organicconsumers gives seemingly accurate quotes and links to it on the ehp.niehs.nih.gov site. > So the above referenced website seems to have resorted to lying. No, not at all. That page's info seems quite true. It doesn't say the study's in pubmed. > > > ARTIFICIAL SWEETENER ASPARTAME CAUSES CANCER IN RATS > > > Scientists are calling for an urgent reevaluation of the artificial [quoted text clipped - 20 lines] > organicconsumers gives seemingly accurate quotes and links > to it on the ehp.niehs.nih.gov site. Actually, in another reply in another newsgroup it was noted that data was NOT being released: http://groups.google.com/group/misc.kids.health/msg/f77a6903f1ca5150?hl=en& Now why would that be? > > So the above referenced website seems to have resorted to lying. > > No, not at all. That page's info seems quite true. > It doesn't say the study's in pubmed. It was not quite true in an earlier notice they sent out... it even got posted on Snopes. Hmmm, you seem to have snipped that bit. Here it is again: http://www.snopes.com/toxins/cheers.asp Explain again with a track record of misusing information (and even withholding data) why they are credible? It seems to me that anything from them should be regarded as suspect. Good thing that humans are not rats eh? ;) So many of the special breeds of line bred rats for research get cancer by just being alive... Line breeding research rats causes cancer!  SignatureOm. "My mother never saw the irony in calling me a son-of-a-bitch." -Jack Nicholson > Good thing that humans are not rats eh? > [quoted text clipped - 4 lines] > > Line breeding research rats causes cancer! New concept for me ... getting cancer by breeding. Boy ... what you people will dream up to attempt to contradict the viability of legitimate medicine. > > Good thing that humans are not rats eh? > > [quoted text clipped - 7 lines] > people will dream up to attempt to contradict the viability of > legitimate medicine. For the record, I avoid aspartame... but not because of that "study". It tends to cause neuropathy. One woman on our dog list had a "toy" breed dog die from ingesting aspartame. It ate a package of sugar free gum made with aspartame. A few hours later, it was dead. Had siezures and stopped breathing. My point is that those damned rats are no longer legitimate research models. Humans are not clones and have variations in reactions to differerent chemicals. Line bred rats are practically clones to give more "uniform" results. It's just not valid when applied to the real human population model! Just like studies on drugs that are done on all male subjects, or sterile females! The monthly hormonal fluctuations cause unpredictable and non-uniform research results if menustrating/child bearing age females are used. I used to work for a company that did drug research testing on humans. So, WTF??? They are going to test a drug that will be used to treat _normal_ females of child bearing age, and not get a legitimate testing model?????? A LOT of it is just bullshit!!! SignatureOm. "My mother never saw the irony in calling me a son-of-a-bitch." -Jack Nicholson >> Good thing that humans are not rats eh? >> [quoted text clipped - 7 lines] > will dream up to attempt to contradict the viability of legitimate > medicine. Legitmate medicine my a.s. We've cured baldness an endless number of times in rats. We've doubled their life spans. Cured them of things God never designed them to ever come down with. And the payoff to us at the drugstore/chemist shop is...? Just because we can breed a mouse to come down with a bizarre disease and then cure it in them doesn't mean it's Legitimate medicine. It's Legitimate medicine when it results in legitmate medicnes. For us humans. Otherwise it's the largest expenditure in history spent by the largest number of researchers in history on things less practical than "it works in vitro". > >> Good thing that humans are not rats eh? > >> [quoted text clipped - 18 lines] > it's the largest expenditure in history spent by the largest number of > researchers in history on things less practical than "it works in vitro". 'zactly... Look at the research for weight loss and leptin. Worked great in rats, was for zip in obese humans. That's just one of many examples. The only reason rodents are used so much is that they are cheap and prolific. They should (seriously folks!) start with pigs, then move to primates. Chimps are very expensive when compared to rats, but a far more legitimate research model. I vote we start using death row inmates. ;-) Cheers! SignatureOm. "My mother never saw the irony in calling me a son-of-a-bitch." -Jack Nicholson >>>Good thing that humans are not rats eh? >>> [quoted text clipped - 19 lines] > it's the largest expenditure in history spent by the largest number of > researchers in history on things less practical than "it works in vitro". Sorry, but I don't buy your premise. Where are your references? I mean legitimate scientific studies, not a link to some homeopathic or alternative medicine site? > >>>Good thing that humans are not rats eh? > >>> [quoted text clipped - 24 lines] > legitimate scientific studies, not a link to some homeopathic or > alternative medicine site? Go to google. He does not need to do your work for you... The reference to leptin that I gave in another post is a good start! Giving Leptin to mice/rats helped them to lose weight. Did not work in humans. Turns out that many obese humans have a receptor sensitivity problem with Leptin. I read it in journals, not on the internet. SignatureOm. "My mother never saw the irony in calling me a son-of-a-bitch." -Jack Nicholson >>>>>Good thing that humans are not rats eh? >>>>> [quoted text clipped - 27 lines] > Go to google. > He does not need to do your work for you... Oh yes he does. First of all, it is he who is questioning the legitimacy of years of a scientifically accumulated body of knowledge that is generally accepted by society. Secondly, google is about as good for finding legitimate scientific studies as a 3 year-old. There is very limited access to medical journals, and no access to repositories that contain results of impartial studies or clinical trials. Don't be so cocky. The burden of proof lies with you if you are making a claim that contradicts commonly accepted knowledge. > The reference to leptin that I gave in another post is a good start! > Giving Leptin to mice/rats helped them to lose weight. [quoted text clipped - 4 lines] > > I read it in journals, not on the internet. If you want to claim that substances that are given to mice/rats don't always turn out to have efficacy in humans, I will be the first to agree...absolutely yes! But mice/rats present a good starting point to use as an animal model (unless you'd like to volunteer your body ... and you know thousands of others who are also willing to do so) and can help to validate whether to try something out in humans. Are mice/rats exactly the same model? Of course not. I agree with that. But this was not the claim that initiated the debate on this post. It was the fact that someone claimed that "So many of the special breeds of line bred rats for research get cancer by just being alive" and "Line breeding research rats causes cancer!". And the poster's name of "OmManPadMeOmelet" just adds so much legitimacy. Gimme a break. My challenge stands ... show me legitimate impartial research that substantiates this ... and I'll believe it. Larry >>>>>>Good thing that humans are not rats eh? >>>>>> [quoted text clipped - 63 lines] > > Larry There are plenty of rat and mouse strains which have a very high spontaneous cancer rate > >>>>>>Good thing that humans are not rats eh? > >>>>>> [quoted text clipped - 66 lines] > There are plenty of rat and mouse strains which have a very high spontaneous > cancer rate I agree, but he want's google references. :-( Thing is, this sort of information is best found in medical research journals at the library. And he's too lazy to go look at them........ I doubt it can be googled. SignatureOm. "My mother never saw the irony in calling me a son-of-a-bitch." -Jack Nicholson >>>>>>>>Good thing that humans are not rats eh? >>>>>>>> [quoted text clipped - 75 lines] > > I doubt it can be googled. And are you too lazy to look beyond google to find them? If they exist and you are so familiar with them, why don't YOU have them handy and why can't you at least reference them? Larry > My challenge stands ... show me legitimate impartial research that > substantiates this ... and I'll believe it. > > Larry Translation: I am one of these theory workers blowing millions of dollars a year. Show me research where others have done the same and reported the results. I just love reading things written by people whose funding kept them employed and made them feel useful but in the end accomplished nothing. If I can't read that, give me the writings of that self important, self taught know it all in Canada who walks around with a chip on his shoulder because he was refused tenure. Amazing. They're called the "hard" sciences. People who study and pursue the "hard" sciences look down on those who work in "voodoo" social sciences or write science fiction. There's an old joke about one's brother in law who invented a cure for which there was no disease. It's not a joke. Done every day with monkeys and mice and real money. It's called, of all things "legitimate medical research" and "hard" science. >>My challenge stands ... show me legitimate impartial research that >>substantiates this ... and I'll believe it. [quoted text clipped - 17 lines] > mice and real money. It's called, of all things "legitimate medical > research" and "hard" science. Terrible argument about ? and a weak response. Suit yourself. If you had a strong case to make, I supposed you would have made it. Larry > But this was not the claim that initiated the debate on this post. It > was the fact that someone claimed that "So many of the special breeds of [quoted text clipped - 6 lines] > > Larry Try here: http://tinyurl.com/8smrw 1,100 references, I'm sure a few of them will contain proof of what I posted. ;-) SignatureOm. "My mother never saw the irony in calling me a son-of-a-bitch." -Jack Nicholson >>But this was not the claim that initiated the debate on this post. It >>was the fact that someone claimed that "So many of the special breeds of [quoted text clipped - 13 lines] > 1,100 references, I'm sure a few of them will contain proof of what I > posted. ;-) OK ... the "open up the paint can and throw it at the wall" philosophy, huh? Is that the best you can do? Very very weak when you are trying to make a case like you are. So I humored you and tried the first five hits. Nothing. That's as far as I will go. I also don't how it's possible based on your search arguments to find studies that "Line breeding research rats causes cancer". I'm still waiting for substantiation of your claim. Larry >> Line breeding research rats causes cancer! > > New concept for me ... getting cancer by breeding. Boy ... what you > people will dream up to attempt to contradict the viability of > legitimate medicine. Some day I'll find where I kept a copy of a newsgroup article written by a guy whose summer job was shipping specially bred white mice for medical research. Among other things, he told of having to wear gloves at all times, because if you touched one of the mice, your skin oils would cause cancer on its skin. SignatureIf John McCain gets the 2008 Republican Presidential nomination, my vote for President will be a write-in for Jiang Zemin. > >> Line breeding research rats causes cancer! > > [quoted text clipped - 7 lines] > at all times, because if you touched one of the mice, your skin oils > would cause cancer on its skin. Thank you!!!!!!! :-) I'd read stuff like that. These damned line bred rodents are so specialized and inbred, they get cancer if you look at them wrong! It's just bad science IMHO. It's not "real". SignatureOm. "My mother never saw the irony in calling me a son-of-a-bitch." -Jack Nicholson > Good thing that humans are not rats eh? Too bad humans aren't fruitflies or rats. We cure everything in those buggers, including death and even more importantly, baldness. Too bad it doesn't translate over to us humans and some of the contributors to sci.life-extension. > > Good thing that humans are not rats eh? > > Too bad humans aren't fruitflies or rats. We cure everything in those > buggers, including death and even more importantly, baldness. Too bad it > doesn't translate over to us humans and some of the contributors to > sci.life-extension. Indeed... ;-) Prove stuff in primate models before publishing. It makes it more relevant. And use normal female models, not sterile ones! Modern research methods to women a serious diservice. :-( SignatureOm. "My mother never saw the irony in calling me a son-of-a-bitch." -Jack Nicholson ******************************************************* Sunday, December 4, 2005 Any unsuspected source of methanol, which the body always quickly and largely turns into formaldehyde and then formic acid, must be monitored, especially for high responsibility occupations, often with night shifts, such as pilots and nuclear reactor operators. http://groups.yahoo.com/group/aspartameNM/message/1237 ubiquitous potent uncontrolled co-factors in nutrition research are formaldehyde from wood and tobacco smoke and many sources, including from methanol in dark wines and liquors, in pectins in fruits and vegetables, and in aspartame: Murray 2005.12.04 http://groups.yahoo.com/group/aspartameNM/message/1250 aspartame causes cancer in rats at levels approved for humans, Morando Soffritti et al, Ramazzini Foundation, Italy & National Toxicology Program of National Institute of Environmental Health Sciences 2005.11.17 Env. Health Pers. 35 pages: Murray As a medical layman, I suggest that evidence mandates immediate exploration of the role of these ubiquitious, potent formaldehyde sources as co-factors in epidemiology, research, diagnosis, and treatment in a wide variety of disorders. Folic acid, from fruits and vegetables, plays a role by powerfully protecting against methanol (formaldehyde) toxicity. Many common drugs, such as aspirin, interfere with folic acid, as do some mutations in relevant enzymes. The majority of aspartame reactors are female. In mutual service, Rich Murray ******************************************************* Rich Murray, MA Room For All rmforall@comcast.net 505-501-2298 1943 Otowi Road Santa Fe, New Mexico 87505 http://groups.yahoo.com/group/aspartameNM/messages group with 148 members, 1,262 posts in a public, searchable archive http://RoomForAll.blogspot.com http://AspartameNM.blogspot.com Dark wines and liquors, as well as aspartame, provide similar levels of methanol, above 100 mg daily, for long-term heavy users, 2 L daily, about 6 cans. Methanol is inevitably largely turned into formaldehyde, and thence largely into formic acid. It is the major cause of the dreaded symptoms of "next morning" hangover. Fully 11% of aspartame is methanol -- 1,120 mg aspartame in 2 L diet soda, almost six 12-oz cans, gives 123 mg methanol (wood alcohol). If 30% of the methanol is turned into formaldehyde, the amount of formaldehyde, 37 mg, is 18.5 times the USA EPA limit for daily formaldehyde in drinking water, 2.0 mg in 2 L average daily drinking water, 185 times the New Jersey limit, 615 times the California and Maine limits, 1850 times the Maryland limit. The 1999 July EPA 468-page formaldehyde profile admits that four states substantially exceed the federal EPA limit: Environmental Protection Agency 2.00 mg in 2 L daily drinking water California and Maine------------ 0.06 mg Maryland---------------------- 0.02 mg New Jersey-------------------- 0.20 mg http://groups.yahoo.com/group/aspartameNM/message/1108 faults in 1999 July EPA 468-page formaldehyde profile: Elzbieta Skrzydlewska PhD, Assc. Prof., Medical U. of Bialystok, Poland, abstracts -- ethanol, methanol, formaldehyde, formic acid, acetaldehyde, lipid peroxidation, green tea, aging: Murray 2004.08.08 2005.07.11 http://groups.yahoo.com/group/aspartameNM/message/835 ATSDR: EPA limit 1 ppm formaldehyde in drinking water July 1999: Murray 2002.05.30 rmforall Aspartame is made of phenylalanine (50% by weight) and aspartic acid (39%), both ordinary amino acids, bound loosely together by methanol (wood alcohol, 11%). The readily released methanol from aspartame is within hours turned by the liver into formaldehyde and then formic acid, both potent, cumulative toxins. http://groups.yahoo.com/group/aspartameNM/message/1106 hangover research relevant to toxicity of 11% methanol in aspartame (formaldehyde, formic acid): Calder I (full text): Jones AW: Murray 2004.08.05 2005.09.28 Since no adaquate data has ever been published on the exact disposition of toxic metabolites in specific tissues in humans of the 11% methanol component of aspartame, the many studies on morning-after hangover from the methanol impurity in alcohol drinks are the main available resource to date. Jones AW (1987) found next-morning hangover from red wine with 100 to 150 mg methanol (9.5% w/v ethanol, 100 mg/L methanol, 0.01%, one part in ten thousand). http://groups.yahoo.com/group/aspartameNM/message/1182 Joining together: short review: research on aspartame methanol, formaldehyde, formic acid) toxicity: Murray 2005.07.08 rmforall http://groups.yahoo.com/group/aspartameNM/message/1071 research on aspartame (methanol, formaldehyde, formic acid) toxicity: Murray2004.04.29 rmforall http://groups.yahoo.com/group/aspartameNM/message/1250 aspartame causes cancer in rats at levels approved for humans, Morando Soffritti et al, Ramazzini Foundation, Italy & National Toxicology Program of National Institute of Environmental Health Sciences 2005.11.17 Env. Health Pers. 35 pages: Murray http://groups.yahoo.com/group/aspartameNM/message/1226 USA National Institutes of Health National Toxicology Program aids eminent Ramazzini Foundation, Bologna, Italy, in more results on cancers in rats from lifetime low levels of aspartame (methanol, formaldehyde), Felicity Lawrence, www.guardian.co.uk: Murray 2005.09.30 http://groups.yahoo.com/group/aspartameNM/message/1186 aspartame induces lymphomas and leukaemias in rats, full plain text, M Soffritti, F Belpoggi, DD Esposti, L Lambertini: Ramazzini Foundation study 2005.07.14: main results agree with their previous methanol and formaldehyde studies: Murray 2005.09.03 http://groups.yahoo.com/group/aspartameNM/message/1189 Michael F Jacobson of CSPI now and in 1985 re aspartame toxicity, letter to FDA Commissioner Lester Crawford; California OEHHA aspartame critique 2004.03.12; Center for Consumer Freedom denounces CSPI: Murray 2005.07.27 http://groups.yahoo.com/group/aspartameNM/message/1143 methanol (formaldehyde, formic acid) disposition: Bouchard M et al, full plain text, 2001: substantial sources are degradation of fruit pectins, liquors, aspartame, smoke: Murray 2005.04.02 rmforall http://groups.yahoo.com/group/aspartameNM/message/1141 Nurses Health Study can quickly reveal the extent of aspartame (methanol, formaldehyde, formic acid) toxicity: Murray 2004.11.21 [ Any scientist can get access to this data for free by submitting a proper research proposal. No one has admitted mining the extensive data on diet soda use and many symptoms for decades for about 100,000 nurses. ] http://groups.yahoo.com/group/aspartameNM/message/1213 aspartame (methanol, phenylalanine, aspartic acid) effects, detailed expert studies in 2005 Aug and 1998 July, Tsakiris S, Schulpis KH, Karikas GA, Kokotos G, Reclos RJ, et al, Aghia Sophia Children's Hospital, Athens, Greece: Murray 2005.09.09 http://groups.yahoo.com/group/aspartameNM/message/939 aspartame (aspartic acid, phenylalanine) binding to DNA: Karikas July 1998: Murray 2003.01.05 rmforall Karikas GA, Schulpis KH, Reclos GJ, Kokotos G Measurement of molecular interaction of aspartame and its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7. Dept. of Chemistry, University of Athens, Greece http://www.chem.uoa.gr gkokotos@atlas.uoa.gr K.H. Schulpis inchildh@otenet.gr G.J. Reclos reklos@otenet.gr http://groups.yahoo.com/group/aspartameNM/message/1088 Murray, full plain text & critique: chronic aspartame in rats affects memory, brain cholinergic receptors, and brain chemistry, Christian B, McConnaughey M et al, 2004 May: 2004.06.05 http://groups.yahoo.com/group/aspartameNM/message/1067 eyelid contact dermatitis by formaldehyde from aspartame, AM Hill & DV Belsito, Nov 2003: Murray 2004.03.30 Thrasher (2001): "The major difference is that the Japanese demonstrated the incorporation of FA and its metabolites into the placenta and fetus. The quantity of radioactivity remaining in maternal and fetal tissues at 48 hours was 26.9% of the administered dose." [ Ref. 14-16 ] Arch Environ Health 2001 Jul-Aug; 56(4): 300-11. Embryo toxicity and teratogenicity of formaldehyde. [100 references] Thrasher JD, Kilburn KH. toxicology@drthrasher.org Sam-1 Trust, Alto, New Mexico, USA. http://www.drthrasher.org/formaldehyde_embryo_toxicity.html full text http://groups.yahoo.com/group/aspartameNM/message/1052 DMDC: Dimethyl dicarbonate 200mg/L in drinks adds methanol 98 mg/L [ becomes formaldehyde in body ]: EU Scientific Committee on Foods 2001.07.12: Murray 2004.01.22 http://groups.yahoo.com/group/aspartameNM/message/925 aspartame puts formaldehyde adducts into tissues, Part 1/2 full text Trocho & Alemany 1998.06.26: Murray 2002.12.22 http://groups.yahoo.com/group/aspartameNM/message/1224 Aspartame disease: an FDA-approved epidemic, H. J. Roberts, MD 2004: Murray 2005.09.30 http://groups.yahoo.com/group/aspartameNM/message/1233 Aspartame -- the shocking story, The Ecologist, 2005 Sept., p. 35-51, full text: Murray 2005.09.30: the correct author, Pat Thomas, What Doctors Don't Tell You www.wddty.co.uk : 2005.10.11 http://groups.yahoo.com/group/aspartameNM/message/1131 genotoxicity of aspartame in human lymphocytes 2004.07.29 full plain text, Rencuzogullari E et al, Cukurova University, Adana, Turkey 2004 Aug: Murray 2004.11.06 http://groups.yahoo.com/group/aspartameNM/message/1228 NM EIB votes 4-2 for 5-day aspartame toxicity hearing July, 2006, requesting a Hearing Officer and a medical expert from Environmental Dept. and legal advice from NM Attorney General: Murray 2005.10.04 http://groups.yahoo.com/group/aspartameNM/message/1237 ubiquitous potent uncontrolled co-factors in nutrition research are formaldehyde from wood and tobacco smoke and many sources, including from methanol in dark wines and liquors, in pectins in fruits and vegetables, and in aspartame: Murray 2005.12.03 http://groups.yahoo.com/group/aspartameNM/message/1261 Time to drop the pop? [ both regular and aspartame soda], Jim Davidson, SouthernIllinoisan.com 2005.12.03: James D Koonce, DDS: Brian H Hardin, MD: Murray http://groups.yahoo.com/group/aspartameNM/message/1262 aspartame safe? Jodi Mailander Farrell, Miami Herald: Claudia M Gonzales, American Dietetic Association: Murray 2005.12.04 ******************************************************* > Methanol is inevitably largely turned into formaldehyde, > and thence largely into formic acid. > It is the major cause of the dreaded symptoms of "next > morning" hangover. The hangover is the result of alcohol metabolized into acetaldehyde, but significant amounts of acetaldehyde not being immediately metabolized into sugar. SignatureIf John McCain gets the 2008 Republican Presidential nomination, my vote for President will be a write-in for Jiang Zemin. |
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