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Medical Forum / General / General / February 2006

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Penlac for toenail fungus?

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Footloose@fancyfree.com - 05 Oct 2003 05:53 GMT
Looked for a podiatry NG but did not find, so
hope you can help.

Why does the podiatrist prescribe Penlac for toenail fungus, when even
he says it really doesn't work because it doesn't penetrate the nail?

He said the oral medication for this condition has a downside; it
can damage the liver.  He rushed out of the room before I could
ask the following:

What is the name of the stuff?

And what is the mechanism by which it can damage the liver?

TIA for info.

--

Footloose
Kent H. - 05 Oct 2003 07:42 GMT
Basically what you put in your mouth doesn't get to your toenail. Fungal
toenail occurs because you have a genetic predispositon to it. Forget
it.

> Looked for a podiatry NG but did not find, so
> hope you can help.
[quoted text clipped - 15 lines]
>
> Footloose
Footlose@fancyfree.com - 06 Oct 2003 07:24 GMT
>Basically what you put in your mouth doesn't get to your toenail. Fungal
>toenail occurs because you have a genetic predispositon to it. Forget
>it.

Well if it's a genetic predisposition, why didn't it show up sooner?
I've had my toe for *quite a while* <g>, and I just noticed the
problem a few years ago.

Also, with due respect for your reply, I don't understand why an M.D.
podiatrist would even mention an oral medicine if it didn't work --
keeping in mind the liver downside, of course.

More puzzled than ever.

--

Footlose

>> Looked for a podiatry NG but did not find, so
>> hope you can help.
[quoted text clipped - 15 lines]
>>
>> Footloose
Kent H. - 08 Oct 2003 17:14 GMT
It doesn't show up in most until later in life. My mother's began at
about age 40 and proceeded slowly until her death 45 years later, from
congestive heart failure, not from the nail problem. Other than being
ugly, it doesn't do anything adverse. At least mine doesn't.
Podiatrists aren't MDs. They are a long way from it. They have about
four years of post high school training, and some intern type training.
They wouldn't be remotely capable of monitoring the possible adverse
side effects of a drug like Penlac years on end and when the side
effects occured they wouldn't know what to do about them. Podiatrists
can be money hungry; many of them are sincere honest providers. Make
sure you are seeing one in the latter category.
There used to be a keratin dissolving product by prescription that
dissolved the excess keratin on the toenail. It was taken off the market
by the FDA.
PENLAC™ NAIL LACQUER (ciclopirox) Topical Solution, 8%, is topical and I
suspect has the same limitations of any topical antifungal drug for the
reasons I gave above. You treat the nail. You don't get to the heart of
the problem. The last time I asked my dermatologist this question that
is essentially the answer I received.
Based on your query, I am going to see a podiatrist and reask the
question. Meanwhile look at:
http://www.pdr.net/display.jsp?url=20800600.htm&productname=Penlac%20Nail%20Lacq
uer,%20Topical%20Solution%20

Obviously, penlac isn't something you want to jump right into.
I will report back, though with my HMO it will take some time.
Cheers,
Kent

> >Basically what you put in your mouth doesn't get to your toenail. Fungal
> >toenail occurs because you have a genetic predispositon to it. Forget
[quoted text clipped - 33 lines]
> >>
> >> Footloose
Kent H. - 09 Oct 2003 02:24 GMT
My internist says that it works; even though it is a topical drug it
gets into the nail bed and treats the underlying fungal infection.
Because my HMO says the treatment is cosmetic, they won't cover it. 6.6
ml of the stuff costs me $110, and I am getting a discount. It's not
available in the Canadian pharmacies. We are screwed.
Kent

> Looked for a podiatry NG but did not find, so
> hope you can help.
[quoted text clipped - 15 lines]
>
> Footloose
Kathy Cole - 12 Oct 2003 22:31 GMT
> He said the oral medication for this condition has a downside; it
> can damage the liver.  He rushed out of the room before I could
> ask the following:
>
> What is the name of the stuff?

My husband has taken said stuff; it's oral Lamisil.  He took it for a
couple of months, as I recall, and over the next couple of months, grew
a fungus-free toenail.  The fungus has not returned.

> And what is the mechanism by which it can damage the liver?

That I can't answer, though hubby did have to have a liver function test
before the doctor would prescribe the med.
Howard Homler - 13 Oct 2003 02:20 GMT
>Looked for a podiatry NG but did not find, so
>hope you can help.
[quoted text clipped - 11 lines]
>
>TIA for info.

The Lamisil treatment is definitely more effective than the topical
treatment, however it is also substantially more expensive.  I've
heard of liver injury in the literature, but in the patients that I've
treated with it, I haven't seen any problems.  There's Sporanox, too,
but that has many more potential drug interactions.  The Penlac is
worth a try, IMHO, unless you have really bad fungal involvement.
Good luck!  H2
daktarin - 18 Feb 2006 06:50 GMT
Athlete foot and fungal infection treatment.
Daktarin is a range of anti-fungal products for the effective treatment of
athlete's foot and other common fungal skin infections. www.daktarin.co.uk.
Here you can find information and advice to help you to perform to your
personal best.
 
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