INTERHEART and ApoB/ApoA1 ratio

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Juhana Harju - 15 Nov 2005 20:45 GMT

I wonder what is the importance of the ApoB/ApoA1 ratio as a predictor of
heart disease. The ratio was found to be one of the strongest predictors in
the large INTERHEART* study. Risk ratio in the lowest versus highest
quintiles of ApoB/ApoA1 ratio was 3.25. Is the ApoB/ApoA1 ratio going to
replace TC:HDL ratio and LDL:HDL ratio in clinical practise as some of the
best predictors of heart disease or does it have some other specific
importance?

*Yusuf S et al, Effect of potentially modifiable risk factors associated
with myocardial infarction in 52 countries (the INTERHEART study):
case-control study. Lancet. 2004 Sep 11-17;364(9438):937-52.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=15364185&query_hl=12

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Juhana Harju - 16 Nov 2005 14:31 GMT

: I wonder what is the importance of the ApoB/ApoA1 ratio as a
: predictor of heart disease. The ratio was found to be one of the
[quoted text clipped - 7 lines]
: associated with myocardial infarction in 52 countries (the INTERHEART
: study): case-control study. Lancet. 2004 Sep 11-17;364(9438):937-52.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=15364185&query_hl=12

The full study gives the answer:

"Because apolipoprotein concentrations are not affected by the fasting
status of the individual (unlike calculated LDL), we used the ApoB/ApoA1
ratio as an index of abnormal lipids in the current analysis. Moreover, this
ratio was predictive of myocardial infarction in subsets of patients (<12 h,
12–24 h, and >24 h after symptoms) in the present study (data not shown)."

http://www.thelancet.com/journals/lancet/article/PIIS0140673604170189/fulltext
(may require registration, but it is free)

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