<<snip>>
higher serum levels of ferritin were found in pruritic patients when
compared to nonpruritic ones
<<snip>>

Uremic pruritus: A review.
Lugon JR
Hemodial Int. 2005 Apr ; 9(2): 180-8

Pruritus is a major disorder among the skin derangements in advanced
renal failure. Its prevalence seems to be diminishing perhaps because
of improvements in dialysis treatment. Recent information suggests that
interactions between dermal mast cells and distal ends of nonmyelinated
C fibers may be important in the precipitation and regulation of the
sensory stimuli. The knowledge as to the control of pruritus
transmission to cortex areas is still incomplete but endogenous opioid
and opioid receptors may have a role in this regard. A recent
classification was proposed for pruritus based on the level of its
origin. Uremic pruritus, however, seems to be too complex to fit
perfectly in any of the suggested modalities. Inflammation and
malnutrition are recognized risk factors for cardiovascular death in
end-stage renal disease patients, which may be related to the genesis
of pruritus. Consistent with this concept, lower serum levels of
albumin and higher serum levels of ferritin were found in pruritic
patients when compared to nonpruritic ones. Newer treatments for this
difficult clinical problem are being developed and tested.

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