 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / General / General / September 2005Reversion of iron-induced memory impairment
Exp Neurol. 2005 Aug 23; [Epub ahead of print] Related Articles, Links Selegiline protects against recognition memory impairment induced by neonatal iron treatment. de Lima MN, Laranja DC, Caldana F, Grazziotin MM, Garcia VA, Dal-Pizzol F, Bromberg E, Schroder N. Programa de Pos-Graduacao em Gerontologia Biomedica, Instituto de Geriatria e Gerontologia, Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande do Sul, 90619-900 Porto Alegre, RS, Brazil. Excess of iron in the brain has been implicated in the pathogenesis of several human neurodegenerative diseases, for example Alzheimer's disease and Parkinson's disease. It has been shown that the neonatal period is critical for the establishment of normal iron content in the adult brain. Moreover, it is known that aging alters the cerebral distribution of this metal. We have recently described that neonatal administration of iron severely impaired novel object recognition memory in rats. The aim of the present study was to determine whether selegiline, a monoamine oxidase (MAO) inhibitor known for its neuroprotective properties, could protect rats against cognitive impairment induced by neonatal administration of iron. In the first experiment, male Wistar rats received vehicle (5% sorbitol in water) or iron (10.0 mg/kg) orally from postnatal days 12 to 14 and saline (0.9% NaCl) or selegiline (1.0 or 10.0 mg/kg) intraperitoneally for 21 days, starting 24 h before the first iron dosing. In the second experiment, rats were given either vehicle or iron (10.0 mg/kg) orally from postnatal days 12 to 14 followed by saline or selegiline (1.0 or 10.0 mg/kg) intraperitoneally for 21 days, starting when rats reached adulthood (50th day after birth). Iron-treated rats given selegiline in both doses showed no deficits in recognition memory. Rats receiving iron but no selegiline presented memory deficits. This is the first study reporting the reversion of iron-induced memory impairment, supporting the view that our model can be considered as a useful tool in the search for new drugs with neuroprotective and/or memory enhancing properties. PMID: 16122736 [PubMed - as supplied by publisher] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking What this article points to is that in any subject, including iron, there are minimal, optimal, and maximal levels of nutritional substances. Minimal to have any effect, optiimun to get the best balance between intake and result, and maximal when adding more leads to negative effects. As mentioned before, low iron intake is the world's number one health problem because too little iron causes mental problems also, just as too much causes them. What the article .. says .. since you can't OBVIOUSLY .. understand .. IS .. iron induces memory impariment .. <<snip>> This is the first study reporting the reversion of iron-induced memory impairment <<snip>> Is that .. REALLY .. that .. HARD .. to .. understand .. ? Must be .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking My reply was in the context of the larger picture of iron level and mental disorders. If one limits oneself to an unrelated patchwork of individual narrowly focused research studies this larger picture is lost. For all nutritional substances, including iron, there is a minimal, an optimal, and a max amount that relate to it's effects in human health. On the low end mental problems result, as do they on the over max end; which was the example the study posted shows. On balance, far more of the world's population have too little which makes it the number one health problem because of the mental health problems it causes in children that persist into aadulthood. And how many groups are you crossposting to now, Ironhead? Sheesh, people like you are like a virus. . . Sylvia > And how many groups are you crossposting to now, Ironhead? > > Sheesh, people like you are like a virus. . . Way too much credit! See the difference between an abstract and the full article at http://www.pedresearch.org/cgi/content/full/55/6/1034 . It is primarily about deafness in neonatals, but also mentions cognition due to too little iron. The web has many articles dealing with cognition or deafness in perinatals caused by lack of iron in the diet. Tommy would have us believe that he knows all this, so we can only speculate on why he posts what he knows to be inaccurate abstracts. Cue Tommy's swearing... -- Spelling and grammatical errors are deliberate to catch copyright violators. ©¿©¬ Perth, Ontario, Canada so we can only speculate on why he posts what he knows to be inaccurate abstracts. << I say .. iron deficiency .. doesn't .. exist .. in a FED society .. Studies seem to support this .. theory .. YOU and your 'ilk' .. continuously wish to refer to studies in which the study groups are comprised of .. in many cases .. severely malnourished and/or 'slightly' impoverished .. I prefer to refer to studies in which the population is .. fed .. Why would I .. care .. whether some starving .. person .. shows signs of .. anemia .. ? cognition .. ? It doesn't .. relate .. WHEREAS .. evidence based medicine .. shows CLEARLY .. the EFFICACY .. of .. iron deprivation / reduction / limitation .. IN .. disease states .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >WHEREAS .. evidence based medicine .. shows CLEARLY .. the EFFICACY .. >of .. iron deprivation / reduction / limitation .. IN .. disease states >.. So... You want to take our normally fed society and withdraw iron from our diet so that we can have a society that is deaf and has cognition problems in addition to whatever other disease we might have. Why? Study after STUDY shows CLEARLY that YOU, YES, YOU, do NOT KNOW what YOU are talking about. Look it up. You are just road kill on the information highway: two eyes flashing in the headlights of a speeding truck and then SPLAT! Another stinking carcass to become fertiliser for the weeds beside the road. --- From: doe (ironjustice@aol.comdoe) Newsgroup: Sci.med Date: 2002-10-13 18:14:20 PST [snip] That would make you even more clueless than me .. or can't you understand that >>WHEREAS .. evidence based medicine .. shows CLEARLY .. the EFFICACY .. >>of .. iron deprivation / reduction / limitation .. IN .. disease states [quoted text clipped - 8 lines] > YOU, YES, YOU, do NOT KNOW what YOU are talking about. Look > it up. Oh, dear, can't you just ignore him, in the way that most of us do? With best wishes, Peter.  SignaturePeter \ / \ Prestbury, Cheltenham, Glos. GL52 Anne \ / __ __ \ England. and / / \ | | |\ | / _ \ http://pnyoung.orpheusweb.co.uk family / \__/ \_/ | \| \__/ \______________ pnyoung@ormail.co.uk. >>You want to take our normally fed society and withdraw iron from our diet so that we can have a society that is deaf and has cognition problems in addition to whatever other disease we might have. << So .. smart .. guy .. Off the topic of your fat fkg head .. what diet WOULD .. disallow the intake of iron .. below .. what .. is NECESSARY .. Come on ... Shouldn't be hard .. Since you and others believe there IS a diet .. devoid of iron .. Three squares .. a .. day .. Devise .. one .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking intake of iron .. below .. what .. is NECESSARY .." Easy, the natural experiment showing this is worldwid and easy to observe. Where a mainly vegetarian diet with only a few items are eaten on an ongo8ing basis the problem of low iron is the standard situation. This is the root cause of low iron in children and women being the world's number one health problem. If one eats a mainly vegetarian diet one must take measures to be sure to include items with enough iron and in a form that can be absorbed readily and isn't in conflict with other foods which inhibit absorbtion. Diets high in milled grains are the main culpret because they are cheap enough for people to afford, this is different from problems from starvation, it's about eating too much os a few kinds of foods. . You can eat a vegetarian diet and get enough iron from plant sources; I've been doing it for over 30 years. And, to Ironhead's eternal chagrin, you can also get MS on such a diet. . .I'm living proof that he is full of horsehockey. But anyone familiar with his rantings does not need any proof of that! Sylvia Actually .. this article seems to say .. even a HIGH .. meat based .. diet .. does not allow one access to enough iron to .. constitute .. ENOUGH .. iron .. in the diet .. or what .. they .. have decided to BE .. sufficient .. iron .. We're .. all .. fkd .. Or so they would have us .. believe .. 1: Br J Nutr. 2005 Jul;94(1):78-83. Related Articles, Links Pork meat increases iron absorption from a 5-day fully controlled diet when compared to a vegetarian diet with similar vitamin C and phytic acid content. Bach Kristensen M, Hels O, Morberg C, Marving J, Bugel S, Tetens I. Department of Human Nutrition, Centre for Advanced Food Studies (LMC), The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. Meat increases absorption of non-haem iron in single-meal studies. The aim of the present study was to investigate, over a 5 d period, the potential increasing effect of consumption of pork meat in a whole diet on the fractional absorption of non-haem iron and the total absorption of iron, when compared to a vegetarian diet. A randomised cross-over design with 3x5 d whole-diet periods with diets containing Danish-produced meat, Polish-produced meat or a vegetarian diet was conducted. Nineteen healthy female subjects completed the study. All main meals in the meat diets contained 60 g of pork meat and all diets had high phytic acid content (1250 mumol/d). All main meals were extrinsically labelled with the radioactive isotope (59)Fe and absorption of iron was measured in a whole body counter. The non-haem iron absorption from the Danish meat diet was significantly higher compared to the vegetarian diet (P=0.031). The mean fractional absorption of non-haem iron was 7.9 (se1.1), 6.8 (se 1.0) and 5.3 (se 0.6) % for the Danish and Polish meat diets and vegetarian diet, respectively. Total absorption of iron was higher for both meat diets compared to the vegetarian diet (Danish meat diet: P=0.006, Polish meat diet: P=0.003). The absorption ratios of the present study were well in accordance with absorption ratios estimated using algorithms on iron bioavailability. Neither the meat diets nor the vegetarian diets fulfilled the estimated daily requirements of absorbed iron in spite of a meat intake of 180 g/d in the meat diets. PMID: 16115336 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking "Actually .. this article seems to say .. even a HIGH .. meat based .. diet .. does not allow one access to enough iron to .. constitute .. ENOUGH .. iron .. in the diet .. or what .. they .. have decided to BE .. sufficient .. iron .." Nope, it is in fact a fatal contridiction to your notions, a little logic saves alot of time. In science when a notion fails we turn from it in pursuit of truth. The article states a normal diet consisting of meat /and or vegetarian diet .. did not meet the requirements of iron absorption .. seemingly contrary to what previous studies .. have shown. The absorption ratios of the present study were well in accordance with absorption ratios estimated using algorithms on iron bioavailability. Neither the meat diets nor the vegetarian diets fulfilled the estimated daily requirements of absorbed iron in spite of a meat intake of 180 g/d in the meat diets << using algorithms on iron bioavailability << This means ESTABLISHED / accepted .. by all .. Neither the meat diets nor the vegetarian diets fulfilled the estimated daily requirements of absorbed iron << CONTRARY to what the ... calculations .. say .. iron is NOT absorbed at a high enough rate .. at THAT food intake .. So .. like I said .. This diet above .. commonly consumed by our .. peers .. does not give one enough iron to .. survive .. According to all those .. smart .. guys .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking *Total consumption per day, 6.4 oz. http://www.superbad.com/1/meat/ The link above tells us to eat 5 - 7 ounces of meat perday .. The study found 180 grams is not enough .. and THAT .. is .. precisely .. 7 ounces of meat .. give or take a few grams .. So .. a .. RECOMMENDED .. amount of meat .. does NOT .. give one enough ... iron .. So .. as I said .. the diet being PRESENTLY consumed .. and which has been consumed for .. forever .. is NOT .. enough to give enough iron .. to .. survive .. 'They' .. screwed up .. again .. I .. guess .. Or are they .. SCREWING .. up .. again ..? Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking What jackass crossposted this? > *Total consumption per day, 6.4 oz. > [quoted text clipped - 20 lines] > Who loves ya. > Tom Good point Tom. Obviously from your conclusion we can also conclude that eating 7oz of meat is safe, in your context. That, of accidental Iron poisoning. Can we agree on that, or are you a moron? To everyone else, cant you see how easy it is to destroy a delusional psychotics delusions? Watch how he tries to skip and dance around the only logical conclusion. That being his own study has shown 7oz of meat does NOT provide enough iron to survive. So we should all strive to eat more than 7oz of meat a day. As Tom says we will not survive by eating less than 7oz of meat. Do I have that right...? Yes, yes I think I do. Next... Rob Rob Good point Tom. Obviously from your conclusion we can also conclude that eating 7oz of meat is safe, in your context. That, of accidental Iron poisoning. Can we agree on that, or are you a moron? << What .. you don't think researchers can be .. wrong .. ? To everyone else, cant you see how easy it is to destroy a delusional psychotics delusions? Watch how he tries to skip and dance around the only logical conclusion. << Logical conclusion .. ? How many approved .. drugs .. have NOW been taken off the market BECAUSE .. they fkd .. up ..? The study says .. the diet we have been consuming for a very long time .. is .. INSUFFICIENT .. to supply the RECOMMENDED doses of iron .. Now if one ACCEPTS THE FKG RECOMMENDED DOES AS CORRECT .. then .. one WOULD COME TO THE LOGICAL FKG CONCLUSION .. that you seem to have accepted .. But .. if one .. KNOWS these braindeadfkgmorons .. LIKE I DO .. then maybe one wouldn't be so .. accepting .. The study 'could' be .. accepted .. as .. THE MARKERS USED ARE SET TOO FKG HIGH AND EVEN A WELL FED PERSON CANNOT GET ENOUGH IRON TO .. fulfill .. THE RECOMMENDED DOSES OF FKG .. iron .. But .. THAT .. would be .. impossible .. BECAUSE .. the researchers are sooooooooooo fkg .. smart .. Eh .. I wonder if it is the same researchers who have had their drugs and cash pulled out from under .. them ..? Nah .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Iron must have impaired my memory or something. . .or did this just come out of the blue after over 2 weeks? Must have been. . .our troll could not make any mistakes, like posting to the wrong newsgroup. Or maybe he's talking to himself again. . . Sylvia Hate to tell you this .. but .. changing the header DOESN'T alter the crosspost .. one ... fkg .. bit .. I suppose your 'handle' of the intricacies of the internet ..mirror.. your ability to keep yourself .. healthy .. Eh .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking Doehead; >Hate to tell you this .. but .. changing the header DOESN'T alter the >crosspost .. one ... fkg .. bit .. >I suppose your 'handle' of the intricacies of the internet ..mirror.. >your ability to keep yourself .. healthy .. And your "handle" of the. . .uses of. . .the English language. . .mirrors. . .your ability to come up. . .with a. . .coherent. . .comprehensive. . .thought. FYI, "handle" is a singular noun, which needed the singular verb, "mirrors" in your sentence. The object of a preposition is NEVER the subject of a sentence. Go back to grammar school. Not to mention your charming uses of the initials instead of "dirty word" trick! You are such a character! Your post. . .made me. . .giggle! Sylvia (still snickering over the antics of our resident clown) >I suppose your 'handle' of the intricacies of the internet ..mirror.. >your ability to keep yourself .. healthy .. >I cannot help you with your decision. However, avoid the looney who calls >himself Doe; he believes that he found a secret code in the Bible which >tells him that iron is responsible for all disease. Begin quote of Msg ID fragment 20021006092541.12706.00008179@mb-fa.aol.com Lets just put it this way .. the above was written by a person who cannot even place their real email signature .. This means they have no ability to post under their own signature any longer due to their rights being pulled by the servers and google usenet groups. This means pretty much they have been proven to be .. nuts. End quote SignatureThe opinions expressed are mine alone. My employer would crap if it were known what I say here. That was real helpful here. Iron must have impaired my memory or something. . .or did this just come out of the blue after over 2 weeks? Must have been. . .our troll could not make any mistakes, like posting to the wrong newsgroup. Or maybe he's talking to himself again. . . Sylvia > *Total consumption per day, 6.4 oz. > [quoted text clipped - 11 lines] > been consumed for .. forever .. is NOT .. enough to give enough iron > .. to .. survive .. Neither does the recommended number of fruit servings give enough vitamin C. > 'They' .. screwed up .. again .. Not at all. You see... unlike you, they have enough brains to know that practically no one eats nothing but meat. > I .. guess .. > [quoted text clipped - 11 lines] > DEAD PEOPLE WALKING > http://pages.ivillage.com/ironjustice/deadpeoplewalking |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.