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Medical Forum / General / General / August 2005

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How long for certain side effects to wear off?

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catlover112233@yahoo.com - 25 Aug 2005 22:37 GMT
I have been on several meds for quite some time, but have also been
experiencing some cardiac symptoms -- both high blood pressure, and
rapid pulse -- which may or may not be related to the meds.  As an
experiment, my doctor and I have agreed that I will be getting off the
meds, one at a time.  (First, off one med, see what effect that has.
Then, if no effect, back on the med, then off the next med, etc.)

The doctor has indicated that, if getting off the meds should result in
decreased blood pressure, or decreased pulse (or both), the result
should start to be evident after about a week or so.  I'm posting here
to get a second opinion.  Assuming one these meds is, in fact, causing
increased BP or pulse rate to begin with, will these side effects
subside after just one week off the medicine?

The meds are:  Desipramine, Remeron, Provigil

I also take a low dose of Zyprexa and a moderate dose of Depakote, but
the doctor seems pretty sure these should not have any cardiac related
effects.  Is he correct here?

Thanks in advance for all informed replies.

CL
Sharon Hope - 26 Aug 2005 05:19 GMT
http://www.healthsquare.com/newrx/ZYP1509.HTM

Gives a layman's information for Zyprexa.  It says, "More common side
effects may include:
...high blood pressure, ...rapid heartbeat..."

If you go to the Zyprexa website www.zyprexa.com, and click on the
Prescribing Information, you will get to
http://pi.lilly.com/us/zyprexa-pi.pdf

Table 1
Treatment-Emergent Adverse Events:
Incidence in Short-Term, Placebo-Controlled Clinical Trials1
with Oral Olanzapine
Chest pain
Tachycardia
Hypertension
These were reported at a 3 to 1 ratio to the placebo group.

You may want to check the rest, in case they also apply.

Further, there is information on various problems when used in combination
with other drugs.
I will leave it to you to compare the drugs you take (or their generic
names) to those known to react badly with Zyprexa.

You don't mention your age, but note, too, the warning at the top of the PI:

WARNING
Increased Mortality in Elderly Patients with Dementia-Related Psychosis -
Elderly
patients with dementia-related psychosis treated with atypical antipsychotic
drugs are at
an increased risk of death compared to placebo. Analyses of seventeen
placebo-controlled
trials (modal duration of 10 weeks) in these patients revealed a risk of
death in the
drug-treated patients of between 1.6 to 1.7 times that seen in
placebo-treated patients. Over
the course of a typical 10-week controlled trial, the rate of death in
drug-treated patients
was about 4.5%, compared to a rate of about 2.6% in the placebo group.
Although the
causes of death were varied, most of the deaths appeared to be either
cardiovascular
(e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in
nature.
ZYPREXA (olanzapine) is not approved for the treatment of patients with
dementia-related psychosis (see WARNINGS).

One doctor was considering prescribing Zyprexa for the cognitive damage my
husband suffered under Lipitor, in addition to myopathy, elevated CK
bordering on rhabdomyolysis, and nerve damage.  I'm glad it didn't happen.
Note this:

Postintroduction Reports
Adverse events reported since market introduction that were temporally (but
not necessarily
causally) related to ZYPREXA therapy include the following: allergic
reaction
(e.g., anaphylactoid reaction, angioedema, pruritus or urticaria), diabetic
coma, pancreatitis,
priapism, rhabdomyolysis, and venous thromboembolic events (including
pulmonary embolism
and deep venous thrombosis). Random cholesterol levels of ?240 mg/dL and
random triglyceride
levels of ?1000 mg/dL have been rarely reported.

>I have been on several meds for quite some time, but have also been
> experiencing some cardiac symptoms -- both high blood pressure, and
[quoted text clipped - 19 lines]
>
> CL
 
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