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Medical Forum / General / General / August 2005

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whole blood or plasma?

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fresh~horses@despammed.com - 11 Aug 2005 05:22 GMT
I'm being approached to donate plasma regularly: every six days. The
pamphlet  doesn't tell me everything I'd like to know. Such as:

# why does it take longer to donate plasma?

# is the needle going to get any bigger? why?

# why can I donate plasma every six days, rather than every 56 days for
whole blood?

# why is my blood type more desirable for plasma than the type most
desirable for whole blood?

# what do they do with plasma they can't do with whole blood?
bae@cs.toronto.no-uce.edu - 11 Aug 2005 15:53 GMT
>I'm being approached to donate plasma regularly: every six days. The
>pamphlet  doesn't tell me everything I'd like to know. Such as:
>
># why does it take longer to donate plasma?

Instead of just filling a blood bag, they hook you up to a machine that
takes blood, centrifuges out the plasma and returns the red blood cells.
It does this repeatedly until a unit of plasma is collected.

># is the needle going to get any bigger? why?

AFAIK, it's the same size, more or less.

># why can I donate plasma every six days, rather than every 56 days for
>whole blood?

It takes your body only a few hours to replace the plasma.  It takes
much longer to replace red blood cells.

># why is my blood type more desirable for plasma than the type most
>desirable for whole blood?

I don't know for sure.  I could do some handwaving, but I'd rather wait
for a more knowledgable person to reply.

Incidentally, all blood types are desirable -- the commoner blood types
are needed in larger quantities because recipients as well as donors
have them more commonly.  Less common types are desirable because they
are harder to find among donors, but still needed by recipients.

># what do they do with plasma they can't do with whole blood?

Plasma is often separated into a variety of different products used to
treat various conditions, e.g. clotting factors for hemophiliacs, gamma
globulin to protect people who have been exposed to some infectious
diseases, and many others.  Because people can donate plasma more
often, it's more available, so most whole blood donations can be used
for transfusions instead of to obtain these blood factors.

You can probably find more detailed and authoritative information on
web sites like the CDC, the American Red Cross, and similar organizations
in other countries.

Donating blood is something most people can do, and it's a form of
volunteer activity that takes little time or energy or talent, so it's
particularly good for people who aren't able to do other volunteer
work.  The only source of blood and blood products is donors.  This
isn't something you can get off the shelf, or reorder from a factory --
people have to make the stuff in their own bodies and be willing to
donate it to save other people's lives.

Everybody wants their country to be a place where blood and blood
products are available when they or their loved ones need them.  The
only way to make your country a place like that is to donate and
encourage others to donate.
fresh~horses@despammed.com - 11 Aug 2005 18:33 GMT
I had a pamphlet with *some*, but not enough, information.

I have donated whole blood for years. While doing so yesterday I was
given the Plasma pamphlet and it was suggested I might want to do that,
instead. It was late.

Not sure I want that honking huge needle in me weekly. But... it's only
a few moments.

Thanks.

Zee
Sbharris[atsign]ix.netcom.com - 11 Aug 2005 19:48 GMT
> ># why can I donate plasma every six days, rather than every 56 days for
> >whole blood?
>
> It takes your body only a few hours to replace the plasma.  It takes
> much longer to replace red blood cells.

COMMENT:

A few hours to replace the water and salts in the plasma (from the
intersitial fluid and the gut), but they want the plasma for the
proteins in it, and it takes a week at least for the liver to
synthesize those.  Regular plasma donors get a simple pre-test for
protein content before they allow them to donate again. This is
especially important since some some plasma is still bought, and people
with a need for money for drugs or something else pressing, may not
tell the truth about when they last donated. And such people, who can
be malnurished or ill or both, can't always replace plasma proteins as
quickly as a healthy donor.

SBH
fresh~horses@despammed.com - 11 Aug 2005 20:26 GMT
> > ># why can I donate plasma every six days, rather than every 56 days for
> > >whole blood?
[quoted text clipped - 16 lines]
>
> SBH

Blood products are donated in Canada. I got a chocolate cookie. But
since they called me in, unexpectedly, I also ate a very good goat
curry three hours before.

But yes, one must answer a lot of questions.

I have more questions, here. Probably I can guess but I'd like to know:

One donates a pint.

Is this a lot?

Does this lowered volume of blood make it easier on my heart, and
harder on my head?

Does donating blood affect cholesterol at all?

Would this apply too with plasma?

However briefly...
fresh~horses@despammed.com - 11 Aug 2005 23:03 GMT
> >I'm being approached to donate plasma regularly: every six days. The
> >pamphlet  doesn't tell me everything I'd like to know. Such as:
[quoted text clipped - 51 lines]
> only way to make your country a place like that is to donate and
> encourage others to donate.

I'm also concerned about the plasmapheresis process. I know they will
give me reassurances. But I don't know that I will be reassured.
bae@cs.toronto.no-uce.edu - 12 Aug 2005 15:55 GMT
>I'm also concerned about the plasmapheresis process. I know they will
>give me reassurances. But I don't know that I will be reassured.

Well, according to the consent form, there's a minute chance of
disastrous effects.  I'm willing to take that chance in order to
contribute to a society in which there will be safe blood and blood
products for everyone who needs them.  Besides, it's far more likely
that I'll have disastrous effects from a traffic accident on my way
there, especially since I walk or bicycle in downtown Toronto.  It's
safer on the subway, but then I put myself at greater risk of
cardiovascular problems if I don't get the exercise from commuting
under my own power.  There are always trade offs.

I don't think there are any personal medical benefits from plasma
donation.  When I donate platelets they weigh me and take my pulse and
blood pressure, which is good to monitor for someone our age.  They also
test the blood for evidence of certain infectious diseases and various
parameters related to general health and blood quality, so I suppose
you might get early warning of some problems that way, or at least have
a lot of baseline data if you do get sick with something later.  But if
you're already donating whole blood every 56 days, you're getting a lot
more monitoring than healthy people need.  IIRC, the newest consent
form states that they may give physical exams occasionally to frequent
plasma donors.

You seem to have a number of misgivings about plasma donation.  You
don't have to do it -- you're doing more than most people by donating
whole blood.  Nobody there will pressure you, nor reassure you more than
mildly:  they want you to be entirely a volunteer.  So think about it,
but put off your decision until you can feel comfortable about it.

Btw, in something like 40 or 50 platelet donations over 25 years I've
never had any but the mildest side effects, i.e. a little tingling in
the lips from the anticoagulant (citrate, IIRC), getting a bit cold
from having my blood run through a refrigerator for an hour and a half
-- no problem, they'll give you a blanket, and the cold is actually
kind of nice in hot weather, and feeling kind of stiff when I get up
after staying in one position for an hour and a half, easily cured by
a good stretch.  AFAIK, plasmapheresis takes less time so you'll have
less of the last two, but you probably won't get to watch a feature
film like platelet donors do in Toronto!
fresh~horses@despammed.com - 12 Aug 2005 16:21 GMT
> >I'm also concerned about the plasmapheresis process. I know they will
> >give me reassurances. But I don't know that I will be reassured.
[quoted text clipped - 37 lines]
> less of the last two, but you probably won't get to watch a feature
> film like platelet donors do in Toronto!

My misgivings with the plasma procedure stem from the fiasco with the
Canadian Red Cross and HCV, and of course sterility. My blood goes into
their equipment and then back into me.

I just need to find out all I can. I'm looking at the platelet donation
pamphlet too. If I don't like what I learn about either of these I'll
stay with whole blood donation.

Thanks for your response. It's very informative.  

Zee
bae@cs.toronto.no-uce.edu - 13 Aug 2005 01:33 GMT
>My misgivings with the plasma procedure stem from the fiasco with the
>Canadian Red Cross and HCV, and of course sterility. My blood goes into
>their equipment and then back into me.

There hasn't been a risk of disease transmission to blood donors since
long before apheresis became routine.

They open a sterile sealed set of tubing, bags and centrifuge liner for each
donation, and discard it afterwards.  Your blood never touches anything else.

>I just need to find out all I can. I'm looking at the platelet donation
>pamphlet too. If I don't like what I learn about either of these I'll
>stay with whole blood donation.

Your best bet would probably be to ask your questions of one of the nurses
at the donation center.

>Thanks for your response. It's very informative.  

You're welcome.
fresh~horses@despammed.com - 22 Aug 2005 02:54 GMT
I can't donate.

Zee

> >My misgivings with the plasma procedure stem from the fiasco with the
> >Canadian Red Cross and HCV, and of course sterility. My blood goes into
[quoted text clipped - 16 lines]
>
> You're welcome.
 
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