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Medical Forum / General / General / July 2005Colitis / iron aggravates inflammation
Inflamm Bowel Dis. 2005 Aug;11(8):744-748. Related Articles, Links Low-dose Oral Ferrous Fumarate Aggravated Intestinal Inflammation in Rats with DSS-Induced Colitis. Erichsen K, Milde AM, Arslan G, Helgeland L, Gudbrandsen OA, Ulvik RJ, Berge RK, Hausken T, Berstad A. >From the *Department of Medicine, daggerDepartment of Pathology, and double daggerLaboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway; section signInstitute of Medicine and parallelDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway; and paragraph signNational Institute of Nutritional and Seafood Research, Bergen, Norway. BACKGROUND:: Oral ferrous iron therapy may reinforce intestinal inflammation. One possible mechanism is by catalyzing the production of reactive oxygen species. We studied the effects of low-dose oral ferrous fumarate on intestinal inflammation and plasma redox status in dextran sulfate sodium (DSS)-induced colitis in rats. METHODS:: Forty male Wistar rats were divided into 5 groups: no intervention, sham gavage (distilled water), ferrous fumarate, DSS, and ferrous fumarate + DSS. Ferrous fumarate was dissolved in distilled water (0.60 mg Fe/kg per day) and administered by gavage on days 1 to 14. All rats were fed a standard diet. Colitis was induced by 5% DSS in drinking water on days 8 to 14. Rats were killed on day 16. Histologic colitis scores, fecal granulocyte marker protein, plasma malondialdehyde, plasma antioxidant vitamins, and plasma aminothiols were measured. RESULTS:: DSS significantly increased histologic colitis scores (P < 0.001) and fecal granulocyte marker protein (P < 0.01). Ferrous fumarate further increased histologic colitis scores (P < 0.01) in DSS-induced colitis. DSS + ferrous fumarate decreased plasma vitamin A compared with controls (P < 0.01). Otherwise, no changes were seen in plasma malondialdehyde, plasma antioxidant vitamins, or plasma aminothiols. CONCLUSION:: Low-dose oral ferrous iron enhanced intestinal inflammation in DSS-induced colitis in rats. PMID: 16043990 [PubMed - as supplied by publisher] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking > a standard diet. Colitis was induced by 5% DSS in drinking water on > days 8 to 14. What I don't get, is this type of colitis the same as humans have?? See, if that is the case then we should have medication to heal this by now. If one knows how it comes about, a cure should be easy. Is that not profitable enough or so?? Putting to many researchers out of work?? If this is not the type of colitis humans get, what good is this research then?? Reminds me of he waste of PUBLIC money for research. They managed to study if!!!! driving in rush hour was stressful on people. DUH, ask any kid and they can even tell you. But no, we had to waste I believe it was $485,000 to scientifically "prove" that. Oh boy...... Just thinking out loud on a glorious thursday morning Another question...Was the dosage decreased to fit the size of the mice or were they overloaded with a human dose. It is a fine line between iron being helpful and not. Individuals who have colitis (I would think) have problems with low iron levels anyway. I wonder about the use of Slow Fe? It is easier on the stomach so does that make it easier on the intestines or harder because that becomes the site of digestion? It seems like 5% is a pretty low number to be called significant. I take slow fe and it does not aggravate my CD...without it I am anemic... >Another question...Was the dosage decreased to fit the size of the mice >or were they overloaded with a human dose. It is a fine line between [quoted text clipped - 3 lines] >on the intestines or harder because that becomes the site of digestion? >It seems like 5% is a pretty low number to be called significant. >Another question...Was the dosage decreased to fit the size of the mice or were they overloaded with a human dose. < We'll assume they are NOT .. stupid .. Below is a comparison of the AMOUNT of iron given as a .. fortificant .. TO .. the mice .. and the second is a .. COMMON .. fortification program .. in .. humans .. If I am not .. mistaken .. the AMOUNT of iron added to the bread / flour is MUCH higher than the amount given to the mouse which created .. inflammation ... So .. according to these two studies the AMOUNT of iron added to the flour is MUCH higher than the amount given to the mouse ... per weight .. and therefore would give credence to the hypothesis that .. iron .. fortification .. COMMON everyday .. iron fortification .. would / could .. BE .. the .. CAUSE .. of inflammation in the gut .. <<snip>> Ferrous fumarate was dissolved in distilled water (0.60 mg Fe/kg per day <<snip>> <<snip>> TABLE 1. Enrichment of food vehicles in Venezuela Nutrient Pre-cooked maize flour Irona (mg/kg) 50.0 White wheat flour Irona (mg/kg) 20.0 a. Ferrous fumarate. http://www.unu.edu/unupress/food/V191e/ch02.htm <<snip>> Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
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