 |
 | Home | Contact Us | FAQ | Search & Site Map | Link to Us |
 | Sign In | Join | Other 45 Sites in Network |
Medical Forum / General / General / July 2005DHEA Normal 1.9 - 7.6 / Mine 567
I had my DHEA levels checked after a few years of adult acne and mild hair loss. I read somewhere I should have this checked. Now that I know it is high, I do not know what is next and my Doctor is out of his area of expertise. My guess is this is because: 1. I am low in some other hormone and my body is pumping up DHEA to make up for it. 2. My DHEA feedback system (if one exists) is confused. 3. Whatever breaks down DHEA when there is too much is not working. 4. OTHER?? 5. Supliments are causing this. I take Niacinmimide and Vitamin C daily, occasionally magnesium and Saw Palmento. Saw Palmeto maybe only thing that would effect? Please give me some ideas as to what may be causing this and what I can do to correct this. Thank you in advance Mike >I had my DHEA levels checked after a few years of adult acne and mild >hair loss. I read somewhere I should have this checked. Now that I [quoted text clipped - 13 lines] >Please give me some ideas as to what may be causing this and what I can >do to correct this. Far and away most likely is that you have nonclassical 21-hydroxylase deficiency, which is a genetic disorder, a form of congenital adrenal hyperplasia, that could easily go undiagnosed in males into adulthood. I'd guess your 17-OH-progesterone level is high too. If your doctor is out of his area of expertise, what has he suggested you do next, then? Hasn't he referred you to an endocrinologist? PF My doc maybe thinks it is suppliment related, it is very doubtful isn't it. I assume I should ask to be refered to an endo. My doc would likely do a 17-OH-progesterone level test, I will ask him. I had a juvenile angiofibroma when 18, which is hormone related, I wonder if this is related to that?? I have thought for years that I had a cortisol problems. Anxiety and a few other syptoms pointed to cortisol or pituitary axis somewhere. I did have a cortisol test once which came back normal. Could this possibly be realted to my brain being in hyperspeed much of the time, I have not been able to drink cafeine for years and have to be carefull I do not stress out... I just saw on one web site that many with this disorder are muscular, I am thin. Perhaps that reference is wrong and I know everyone is diferent? Should I have my 9 year old son checked for this if I am diagnosed with nonclassical 21-hydroxylase deficiency? PF Thank!!! for your help, I have been working on this on and off for seven years hoefully you have pointed me in the right direction. If you have any more thoughts please share! Thanks Again Mike >My doc maybe thinks it is suppliment related, it is very doubtful isn't >it. I assume I should ask to be refered to an endo. My doc would >likely do a 17-OH-progesterone level test, I will ask him. Just keep in mind that your elevated DHEA-S still could be from something else. Also, some people with 21-hydroxylase deficiency have normal DHEA-S. Thus, DHEA-S is a poor screening test for 21-hydroxylase deficiency. Did you have other hormone levels done at the same time? What were the results (with reference ranges)? Most certainly even a single hormone level so wildly out of range is an appropriate indication for an endocrinology evaluation. The subtleties of figuring out exactly what the next diagnostic steps should be are best worked out by a specialist. Regarding 21-hydroxylase deficiency, the best screening test is 17-OH-progesterone, but in mild cases (nonclassical) it may be normal, unless it is (1) drawn in the early morning, and/or (2) drawn after ACTH stimulation (60 minutes after an IV bolus of cosyntropin 0.25 mg). >I had a juvenile angiofibroma when 18, which is hormone related, I >wonder if this is related to that?? Nah. >I have thought for years that I had a cortisol problems. Anxiety and a >few other syptoms pointed to cortisol or pituitary axis somewhere. I [quoted text clipped - 6 lines] >am thin. Perhaps that reference is wrong and I know everyone is >diferent? Yes, nothing is 100%. >Should I have my 9 year old son checked for this if I am diagnosed with >nonclassical 21-hydroxylase >deficiency? Sure. If you are. >PF Thank!!! for your help, I have been working on this on and off for >seven years hoefully you have pointed me in the right direction. If >you have any more thoughts please share! You're welcome. Let us know what you find out. PF I have had the normal blood work, TSH, free T4, all normal ranges and (I can provide upon request) others Estradiol Mine 22 Normal 18-67 pg/ml Estrone Mine 45pg/ml Normal men less than 65pg/nml Pregestrone Mine .65 Normal for men .11 - .56 ELEVATED Estrogen Mine 67 Normal ?men or ?female 29-127pg/ml SHBG Mine 34 Normal 13-71 nmol/L Testosterone Total Mine 375 Normal 350-890 ng/dl Testosteone Free Mine 55.8 Normal 47 So if progesterone is the same as 17-OH-progesterone you called it. I will point this out to my doctor along with your feelings. Thanks! >So if progesterone is the same as 17-OH-progesterone you called it. I >will point this out to my doctor along with your feelings. Progesterone is not the same as 17-OHP but the elevation of progesterone and DHEA-S along with your symptoms makes me even more suspicious for 21-hydroxylase deficiency. I'd really really be interested in a 17-OHP stim test result as the next step. Put in an IV at 6 or 7 a.m., infuse cosyntropin 0.25 mg IV, draw 17-OHP level one hour later. I'll bet dollars to doughnuts it's elevated. PF |
Reply to this Message |
 Sign In
 Join
 My Latest Posts My Monitored Threads My Blog My Photo Gallery My Profile My Homepage Start New Thread Enable EMail Alerts Rate this Thread
|
©2008 Advenet LLC Privacy Policy - Terms of Use
This website includes both content owned or controlled by Advenet as well as content owned or controlled by third parties.