Hello,

Lactate dehydrogenase, also called lactic dehydrogenase, or LDH, is an
enzyme found in the cells of many body tissues, including the heart,
liver, kidneys, skeletal muscle, brain, red blood cells, and lungs. It
is responsible for converting muscle lactic acid into pyruvic acid. It
catalyses the interconversion of pyruvate and lactate an essential step
in producing cellular energy.LDH is often used as a marker of tissue
breakdown/damage. As LDH is abundant in red blood cells, it can
function as a marker for hemolysis.

I want to know:-

Can imbalanced Lactic Acid be responsible for tissue breakdown/damage &
trigger secretion of LDH enzyme from the cells for the puepose that
excess lantic acid, if exposed to tissues, is converted into pyruvate
to lessen the toxic effect of LA?

Can there be chronic imbalanced levels of lactic acid in tissues (in
ICF or ECF in diabetic patients?

Best wishes.