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Medical Forum / General / General / July 2005

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Nicotine Withdrawal Question?

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John Schutkeker - 13 Jun 2005 18:23 GMT
How long do withdrawal symptoms last when a person quits using nicotine?
Robert A. Fink, M. D. - 13 Jun 2005 19:45 GMT
>How long do withdrawal symptoms last when a person quits using nicotine?

It varies.  The worst is generally over at 10 days to 2 weeks, but
there can be recurring cravings for as long as a year after quitting.

In my case, I used the patch and I was free of almost all cravings
after about 3 months (I used the patch only for about 8 weeks).

I have been nocitine-free for almst 10 years now and have had no
cravings at all.

Best,

Bob
John Schutkeker - 13 Jun 2005 23:44 GMT
>>How long do withdrawal symptoms last when a person quits using nicotine?
>
> It varies.  The worst is generally over at 10 days to 2 weeks, but
> there can be recurring cravings for as long as a year after quitting.

Is there a nicotine antagonist that can trigger immediate withdrawal, like
naltrexone does for opiates?

> In my case, I used the patch and I was free of almost all cravings
> after about 3 months (I used the patch only for about 8 weeks).
> I have been nocitine-free for almst 10 years now and have had no
> cravings at all.

It's surprising that you should be an MD and find the patch necessary.  My
dad was a physician, in the days before the patch, and he had a method of
slowly weaning people from cigarettes.  I've always believed that it should
work for other highly addictive drugs, like heroin.

I don't think you'd need rapid detox if you just meter your dosage
precisely and slowly, methodically reduce it.  It may be slow, but it's
cheap and a lot less dangerous.
Robert A. Fink, M. D. - 16 Jun 2005 01:21 GMT
>>>How long do withdrawal symptoms last when a person quits using nicotine?
>>
[quoted text clipped - 3 lines]
>Is there a nicotine antagonist that can trigger immediate withdrawal, like
>naltrexone does for opiates?

>> In my case, I used the patch and I was free of almost all cravings
>> after about 3 months (I used the patch only for about 8 weeks).
[quoted text clipped - 9 lines]
>precisely and slowly, methodically reduce it.  It may be slow, but it's
>cheap and a lot less dangerous.

I disagree.  "Weaning" does not work with cigarette withdrawal.  Most
folks who "wean" fail.  Same thing holds true with alcoholism.  It
appears that you have to stop "cold turkey".

If you can handle the distress and pain, fine; but the patch is very
helpful, much like Methadone is helpful during opiate withdrawal.

The nicotine patch, by the way, is not particularly "dangerous".  It
is not recommended that someone using the nicotine patch smoke as
well, as the dosage of nicotine may be too high.

Best,

Bob

Robert A. Fink, M. D.
Neurological Surgery
2500 Milvia Street  Suite 222
Berkeley, CA  94704-2636  USA
510-849-2555

**********************************
NOTE:  The material above is not "medical
advice".  Medical advice can only be
given after an in-person contact between
doctor and patient.
**********************************
John Schutkeker - 16 Jun 2005 15:18 GMT
Well, I've found my nicotine antagonist.  It's name is mecamylamine, and it
triggers instantaneous withdrawal.  Do you know if antagonist triggered
nicotine withdrawal will last just as long as ordinary withdrawal, or will
it end sooner, but be more intense?
Robert A. Fink, M. D. - 17 Jun 2005 21:41 GMT
>Well, I've found my nicotine antagonist.  It's name is mecamylamine, and it
>triggers instantaneous withdrawal.  Do you know if antagonist triggered
>nicotine withdrawal will last just as long as ordinary withdrawal, or will
>it end sooner, but be more intense?

Mecamylamine (Inversine) is a drug occasionally used for the control
of high blood pressure.  It is moderately toxic and can have
interactions with a number of other medicines, including antibiotics.
I have never heard of it as a nicotine antagonist.

Do you have citations?

Best,

Bob

Robert A. Fink, M. D.
Neurological Surgery
2500 Milvia Street  Suite 222
Berkeley, CA  94704-2636  USA
510-849-2555

**********************************
NOTE:  The material above is not "medical
advice".  Medical advice can only be
given after an in-person contact between
doctor and patient.
**********************************
John Schutkeker - 18 Jun 2005 17:43 GMT
> Mecamylamine (Inversine) is a drug occasionally used for the control
> of high blood pressure.  It is moderately toxic and can have
> interactions with a number of other medicines, including antibiotics.
> I have never heard of it as a nicotine antagonist.
>
> Do you have citations?

http://www.cochrane.org/cochrane/revabstr/AB001009.htm

Mecamylamine is just the first nicotine antagonist I fund when searching
Google with that character string.  If other drugs are more commonly used,
or more effective, I'd love to know their names.

But my original question still stands, and mecamylamine's status as such
really isn't relevant to it.  All that matters is that nicotine antagonists
do, in fact, exist.

Is there any reason to believe that NA triggered withdrawal will pass any
more quickly than non-NA induced withdrawal?
Robert A. Fink, M. D. - 20 Jun 2005 20:52 GMT
>Is there any reason to believe that NA triggered withdrawal will pass any
>more quickly than non-NA induced withdrawal?

I haven't heard of any, especially when the use of such is so limited.

Best,

Bob

Robert A. Fink, M. D.
Neurological Surgery
2500 Milvia Street  Suite 222
Berkeley, CA  94704-2636  USA
510-849-2555

**********************************
NOTE:  The material above is not "medical
advice".  Medical advice can only be
given after an in-person contact between
doctor and patient.
**********************************
John Schutkeker - 22 Jun 2005 01:07 GMT
>>Is there any reason to believe that NA triggered withdrawal will pass
>>any more quickly than non-NA induced withdrawal?
>
> I haven't heard of any, especially when the use of such is so limited.

So that means that the only reason not to do rapid detox on smokers is that
it's not economical to check somebody into a hospital for two weeks, as
opposed to three days, as they do for heroin, right?
Robert A. Fink, M. D. - 22 Jun 2005 21:16 GMT
>So that means that the only reason not to do rapid detox on smokers is that
>it's not economical to check somebody into a hospital for two weeks, as
>opposed to three days, as they do for heroin, right?

It is rare to detox heroin addicts in a hospital setting unless the
addiction is connected with a medical condition (which caused the
intractable pain), which is also going to be treated, for example, by
surgery).  Most opiate addiction cases are treated on an outpatient
basis.

Nicotine withdrawal, especially if ameliorated by something like the
patch, does not require in-patient hospitalization.  The same as with
opiate withdrawal, when modified by Methadone.

Best,

Bob

Robert A. Fink, M. D.
Neurological Surgery
2500 Milvia Street  Suite 222
Berkeley, CA  94704-2636  USA
510-849-2555

**********************************
NOTE:  The material above is not "medical
advice".  Medical advice can only be
given after an in-person contact between
doctor and patient.
**********************************
John Schutkeker - 27 Jun 2005 23:27 GMT
> It is rare to detox heroin addicts in a hospital setting unless the
> addiction is connected with a medical condition (which caused the
[quoted text clipped - 5 lines]
> patch, does not require in-patient hospitalization.  The same as with
> opiate withdrawal, when modified by Methadone.

I was referring to rapid detox for opiates, which IS done on an inpatient
basis under general anesthesia, and isn't rare at all.  Whether or not it
is assisted by the patch, out-patient nicotine withdrawal has a notoriously
low success rate, suggesting that a derivative of rapid detox might be a
substantially more effective treatment option.
Robert A. Fink, M. D. - 27 Jun 2005 23:59 GMT
> was referring to rapid detox for opiates, which IS done on an inpatient
>basis under general anesthesia, and isn't rare at all.

Please give me some citations for that.  I have difficulty conceiving
of a place keeping a patient under general anesthesia for days to deal
with opiate withdrawal symptoms.

Best,

Bob

Robert A. Fink, M. D.
Neurological Surgery
2500 Milvia Street  Suite 222
Berkeley, CA  94704-2636  USA
510-849-2555

**********************************
NOTE:  The material above is not "medical
advice".  Medical advice can only be
given after an in-person contact between
doctor and patient.
**********************************
John Schutkeker - 13 Jul 2005 16:59 GMT
>> was referring to rapid detox for opiates, which IS done on an inpatient
>>basis under general anesthesia, and isn't rare at all.
>
> Please give me some citations for that.  I have difficulty conceiving
> of a place keeping a patient under general anesthesia for days to deal
> with opiate withdrawal symptoms.

http://www.rapid-detox.org/

I'm surprised that you missed this.  It's been all over the news, and the
story is two or three years old, so it's not like it's a recent
development.  They're even doing it at the ER in my local hospital, the
Beamont, which is second only the the UM med school in the Detroit area.

I'm not an MD, but I don't think that the requirements are very demanding
for maintaining somebody while they're asleep for three days.  My guess is
that the biggest risk would be that they have a seizure and need a shot of
ativan.
 
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