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Medical Forum / General / General / June 2005Iron deposition / ambulatory impairment in multiple sclerosis
http://tinyurl.com/d535u <<snip>> This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in MS. <<snip>> Journal of the Neurological Sciences Article in Press, Corrected Proof - Note to users doi:10.1016/j.jns.2005.02.009 Copyright © 2005 Elsevier B.V. All rights reserved. MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis C.W. Tjoaa, R.H.B. Benedicta, b, c, B. Weinstock-Guttmana, A.J. Fabianoa and R. Bakshid, , aDepartment of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA bDepartment of Psychiatry University at Buffalo, State University of New York, Buffalo, NY, USA cDepartment of Psychology, University at Buffalo, State University of New York, Buffalo, NY, USA dDepartments of Neurology and Radiology, Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham & Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur-HIM 730 Boston, MA 02115, USA Received 29 October 2004; revised 24 January 2005; accepted 18 February 2005. Available online 22 April 2005. Abstract Objectives MRI T2 hypointensity in multiple sclerosis (MS) gray matter, suggesting iron deposition, is associated with physical disability, disease course, lesion load, and brain atrophy. Ambulatory dysfunction limits quality of life; however correlation with conventional MRI remains poor. Methods Normalized intensity on T2-weighted images was obtained in the basal ganglia, thalamus, red nucleus, and dentate nucleus in 47 MS patients and 15 healthy controls. Brain T1-hypointense and FLAIR-hyperintense lesion volume, third ventricle width, brain parenchymal fraction and timed 25 foot walk (T25FW) were measured in the MS group. Results T2 hypointensity was present throughout gray matter in MS vs. controls (all p < 0.01). Dentate T2 hypointensity was the only MRI variable significantly correlated with T25FW (Pearson r = -0.355, p = 0.007) and was also the best MRI correlate of physical disability (EDSS) score in regression modeling (r = -0.463, R2 = 0.223, p = 0.004). Conclusions T2 hypointensity is present in subcortical gray matter nuclei in patients with MS vs. normal controls. Dentate nucleus T2 hypointensity is independently related to ambulatory impairment and disability, accounting for more variance than conventional lesion and atrophy measures. This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in MS. Keywords: MRI; Multiple sclerosis; Iron; Gray matter; T2 shortening; Ambulation Corresponding author. Tel.: +1 617 732 8600; fax: +1 617 525 5223. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking ><<snip>> >This study adds more weight to the notion that T2 hypointensity is a >clinically relevant marker of tissue damage in MS. ><<snip>> Do you have any idea how many times you have posted this same piece of crap that has never been supported by another institution or researcher? You steadfastly refuse to answer questions put to you about it and after all this time Bakshi is beginning to back off and now say that his work only "suggests". His earlier statements expressed far more certainty. See how many times you have run off and hid with your tail between your legs, just follow the link below. http://tinyurl.com/cwz9t -- Gardening Zones Canada Zone 5a United States Zone 3a Near Ottawa, Ontario >Do you have any idea how many times you have posted this same piece of crap < Available online 22 April 2005. Jeez .. the date says I couldn't have posted it .. before .. what? .. April 22 , 2005 ..? Maybe .. I .. just .. missed .. it .. Who fkg .. cares whether I missed it or .. not .. Read .. my .. lips .. jrkff .. STAY .. off .. my .. threads .. You have a .. problem .. with .. ME .. So .. keep .. it .. to .. your .. fkg .. self .. Too hard for ya .. ? Must .. be .. While I'm here should I post how .. minocycline .. is .. an iron chelator .. ? Jeez .. I just .. did .. Heh .. heh .. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking >>Do you have any idea how many times you have posted this same >piece of crap < [quoted text clipped - 7 lines] > >Who fkg .. cares whether I missed it or .. not .. You have been posting Bakri's article every year since the year 2000; he just re-writes it. Can you not remember these things? I guess you have cognitive problems. Iron deficiency can cause that, you know. >Read .. my .. lips .. jrkff .. > >STAY .. off .. my .. threads .. No. In fact I might post the other warning about you. You know the one. >You have a .. problem .. with .. ME .. > >So .. keep .. it .. to .. your .. fkg .. self .. I do not have a problem with you Tommy, you have a problem with yourself. If you were smart, you would run, not walk, to the nearest psychiatrist's office. But everyone knows you are not smart so what word is the opposite of smart? >Too hard for ya .. ? > >Must .. be .. One day the folks in the clean white suits will come for you. In the meantime, I find you a good target for my frustrations. Nothing more. >While I'm here should I post how .. minocycline .. is .. an iron >chelator .. ? > >Jeez .. I just .. did .. Why would you want to remove one of the best antioxidants in existence? >Heh .. heh .. Heh .. heh .. right back atcha, stunned one. You are seeing this message because Tom Hennessy aka ironjustice@aol.com has posted a message. If you are new to these groups then please understand that he appears to get his thrills from the misfortunes of other people, evidenced by his comments to the victims of forest fires, the passing of members of these newsgroups and his presence on all support newsgroups rather than the more appropriate sci.med.* hierarchy. In keeping with his personality, Tommy believes discussions in these groups are conducted by using off-colour language and name calling that would make a rattlesnake spew. This personality trait is shown here: http://flyembie.notlong.com He seems to believe that whoever swears loudest and longest is the winner. In his mind, Hennessy believes he is a great researcher who has won a Nobel Prize. In fact, he merely copies medical material from the web and pastes it to usenet, proudly calling this his research. There was a time when people like Tommy were institutionalized, now they are allowed to run for public office and post to usenet. He is a fine example why a mental health unit should not obtain an internet account. Previous addresses include watchman@nucleus.com, thennessy@telus.net, darreltaylor911@hotmail.com. -- Gardening Zones Canada Zone 5a United States Zone 3a Near Ottawa, Ontario > ><<snip>> > >This study adds more weight to the notion that T2 hypointensity is a [quoted text clipped - 9 lines] > many times you have run off and hid with your tail between your > legs, just follow the link below. I imagine he's back with his out-of-context Bible verses and inapplicable "research" because his DEERly beloved Wife of His Youth is as ticked at him as we are. Yes, Tom, you a.s, I did read it all: I just wasn't about to play _your_ game. Bed, Twerp! Tk yp fkg crp elswhr. Who doesn't love ya? Your DEERly beloved. I'll be looking for her come Deer Season. Have a nice eternity -- one might hope in oblivion. Bye. Time for entry number three in my killfile. Sad, because there's the barest possibility some little piece of his Nobel Prize project just might apply. If only he had learned elementary politeness in grammar school. "... He'll pace allright but then look carefully at how, reaching the edge, he turns around... ... that quick step revolving on the one hind leg, bringing the other down just as the swivel ends, then giving over all the weight to one front paw, onto each pad distinctly it would seem, then onto number four and he's around headed the other way again." ~ Jorie Graham, >From "The Sense of an Ending," >From "Erosion" * "... better off just Going for The Blinking Lynx, An adept solution, if the Lynx thinks, too. If not, too primitive yet, too innocent, tme thinks To meet The Minx." ~ Frank Lodge "A Crosse, X, Marks the spot, one the distal, an S, the proximal, a U." ~ Kenneth "And, moreover, alas, ever after, some Mulberry Wine from Muldavia, some cherry picking For our homework, And more than unlikely More Graham snackin' crackers later, Smore mores too ..." ~ Keenkix * Darkness Visible ~ "No woe for me Twittering One 'No light, but rather darkness visible.' Look carefully. It is an oxymoron which isn't so. ... 'Illumination' as revealed by differing shades of darkness." ~ Raving "Chiaroscuro, or Sfumato?" ~ Folly "O, I know ~ Ask Leonardo ~ ! Heck, Yeah ~ !" ~ Twittering "Heck, yeah ~ ! Leonardo knows everything ~ !" ~ Folly "Bed, Twerp! Tk yp fkg crp elswhr. Who doesn't love ya? Your DEERly beloved. I'll be looking for her come Deer Season. Have a nice eternity ~ One might hope in oblivion." ~ Husvar "Okey dokey." ~ Twittering >I'll be looking for her come Deer Season. < Heh .. heh http://tinyurl.com/dd9r6 Currently, Singh's group is checking whether prions from distant species such as deer and elk can cross the human intestinal barrier. Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking |
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