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> > > : Certain blood pressure medications and cholesterol medications cause
> > > some
[quoted text clipped - 26 lines]
> Acute tubular necrosis
> Acute renal failure
Yes, those are two reasons rhabdomyolysis is best avoided, and why those
with pre-existing kidney disease processes can be at a higher risk of
it, especially if on fibrate therapy as well (many kidney diseases cause
elevation of triglyceride levels, which is usually treated with
fibrates).
Here are some more complications, taken from American Family Physician:
Early complications
Hyperkalemia
Hypocalcemia
Hepatic inflammation
Cardiac arrhythmia
Cardiac arrest
Late complications
Acute renal failure
Disseminated intravascular coagulation
Early or late complication
Compartment syndrome
Another complication of rhabdomyolysis is death.
> I also found out from the report that statin medications can in some cases
> be the cause of Rhad...
I should have clarified that statins taken with fibrates pose a higher
risk of rhabdomyelosis; I have no idea if bile acid resins or nicotinic
acid taken with fibrates increase this risk.
More from AFP (3/1/2002):
Medications and Toxic Substances That Increase the Risk of
Rhabdomyolysis
Direct myotoxicity
HMG-CoA reductase inhibitors, especially in combination with
fibrate-derived lipid-lowering agents such as niacin (nicotinic acid;
Nicolar)
Cyclosporine (Sandimmune)
Itraconazole (Sporanox)
Erythromycin
Colchicine
Zidovudine (Retrovir)
Corticosteroids
Indirect muscle damage
Alcohol
Central nervous system depressants
Cocaine
Amphetamine
Ecstasy (MDMA)
LSD
Neuromuscular blocking agents
Traumatic, Heat-Related, Ischemic and Exertional Causes of
Rhabdomyolysis
Traumatic causes
Lightning strike
Immobilization
Extensive third-degree burn
Crush injury
Heat-related causes
Heatstroke
Malignant hyperthermia
Neuroleptic malignant syndrome
Ischemic causes
Ischemic limb injury
Exertional causes
Marathon running
Physical overexertion in untrained athletes
Pathologic muscle exertion
Heat dissipation impairment
Physical overexertion in persons with sickle cell disease
Infectious, Inflammatory, Metabolic and Endocrinologic Causes of
Rhabdomyolysis
Infectious causes
Viruses: influenza virus B, parainfluenza virus, adenovirus,
coxsackievirus, echovirus, herpes simplex virus, cytomegalovirus,
Epstein-Barr virus, human immunodeficiency virus
Bacteria: Streptococcus, Salmonella, Legionella, Staphyloccus and
Listeria species
Inflammatory causes
Polymyositis
Dermatomyositis
Capillary leak syndrome
Snake bites (mostly in South America, Asia and Africa)
Metabolic and endocrinologic causes
Electrolyte imbalances: hyponatremia, hypernatremia, hypokalemia,
hypophosphatemia, hypocalcemia
Hypothyroidism
Thyrotoxicosis
Diabetic ketoacidosis
Nonketotic hyperosmolar syndrome
Genetic Causes of Rhabdomyolysis
Lipid metabolism
Carnitine palmitoyltransferase deficiency
Carnitine deficiency
Short-chain and long-chain acyl-coenzyme A dehydrogenase deficiency
Carbohydrate metabolism
Myophosphorylase deficiency (McArdle's disease)
Phosphorylase kinase deficiency
Phosphofructokinase deficiency
Phosphoglycerate mutase deficiency
Lactate dehydrogenase deficiency (characteristic elevation of creatine
kinase level with normal lactate dehydrogenase level)
Purine metabolism
Myoadenylate deaminase deficiency
Duchenne's muscular dystrophy

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Jason - 03 Jun 2005 17:29 GMT
> > > > : Certain blood pressure medications and cholesterol medications cause
> > > > some
[quoted text clipped - 141 lines]
> Myoadenylate deaminase deficiency
> Duchenne's muscular dystrophy
REP,
Thanks for the information--your post had some info. that was not in the
report that I downloaded from MedlinePlus. Thanks so much--are there any
alternative medications to control Chol. other than statin medications?
I'll post another message related to this issue.
thanks again,
Jason

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