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Medical Forum / General / General / May 2005Procyclindine and Tardive Dyskineasia - please help!
I have recently been diagnosed with what my GP believes to be Tardive Dyskinesia as a result of taking Triflouperazine for a period of several months (I was eventually hospitalized due to a really bad reaction to the drug). I have tremors in my hands and legs which are extremely distressing and have been proscribed Procyclidine in order to alleviate the symptoms. However the opposite appears to be happening - the tremors get *worse* after I have taken the drug. I also experienced hot flushes, feelings of nausea and I had to keep urinating about every half hour... I went to the doctor this afternoon (not my usual doc - he's on holiday) and he seemed to know very little about the condition or the side effects of the drug I am taking (having your doc look up your condition and pills in his little medical book in front of you doesn't exactly fill you with confidence :) ). He told me to stop the Procyclidine and instead take Chlordiazepoxide (my usual tranquilizer) regularly. Doesn't seem to have had any effect on the tremors either. This really sucks. Can anyone advise me about what the hell I can do about this or suggest something that will stop me shaking like a leaf? I'm honestly at my wit's end here and I feel like smashing my head against the wall until I pass out... >I have recently been diagnosed with what my GP believes to be Tardive >Dyskinesia as a result of taking Triflouperazine for a period of [quoted text clipped - 21 lines] >at my wit's end here and I feel like smashing my head against the wall >until I pass out... You need to go back to the doctor and tell him what is happening. If your doctor looks things up in his little book, that would make me believe that he is willing to learn instead of relying on his memory to diagnose and treat you. Ora >You need to go back to the doctor and tell him what is happening. My usual GP is fantastic - he just always seems to be on holiday when I really need him. :) I'm seeing my consultant psychiatrist on Monday - I hope that she'll be able to give me some answers, or something to stop these damn tremors - I can't even hold a pen to write with and I'm typing this with two fingers... >If your doctor looks things up in his little book, that would make me believe >that he is willing to learn instead of relying on his memory to diagnose and >treat you. He struck me as clueless to be honest. He didn't even take a proper look at my symptoms, was *very* patronizing and even went as far to suggest that I was making a mountain out of a molehill because I suffer from depression and paranoid thoughts. So, has anyone else ever heard of Procyclidine having a negative effect on Tardive Dyskinesia? I've seen it stated on a few websites but I know better than to believe everything I read on the internet... I've read quite a few very worrying things about TD - could someone here give me a plain English explanation WRT treatment and long-term symptoms? There's no long-term treatment for the long term problems, but wait for it to go away. Which it sometimes does and sometimes doesn't. Tardive dyskinesia (the long term manifestations) usually doesn't look like a tremor, though (these are all more like a case of fidgits, specially involving the face, and not being able to stop moving around). Also, a couple of months of neuroleptic is usually not long enough to give you a bad case. A tremor associated with a neuroleptic is usually part of an early reaction called "extrapyramidal symptoms" which looks a lot like Parkinson's disease--- ridgitity and hand tremor. This is not permanent and reponds often quickly to anticholinergic drugs. If you have some Benedryl you might see if it helps. In any case, it's not likely to last long, once you're off the drug. SBH Wups, procyclidine is an anticholinergic. So you've already tried the drug which was mostly likely to help. Well, I'm out of guesses. Are you taking NO other medications? Perhaps a trial of another anticholinergic is still warrented. These are very odd symptoms for you to be having from procyclidine. >Wups, procyclidine is an anticholinergic. So you've already tried the >drug which was mostly likely to help. Well, I'm out of guesses. Are you >taking NO other medications? I'm taking Aripiprazole (tremors started before I began it) and Escitalopram (been taking it for a year or so with no ill effect). >Perhaps a trial of another anticholinergic is still warrented. These >are very odd symptoms for you to be having from procyclidine. I was thinking this morning that maybe I am having a reaction *to* the procyclidine - these tremors only really started once I began taking it. I was hospitalized with a swollen tongue and breathing difficulties due an increased dose of trifluoperazine but once I got home, I was okay for a day and a half before the tremors came on... >I was thinking this morning that maybe I am having a reaction *to* the >procyclidine - these tremors only really started once I began taking >it. I was hospitalized with a swollen tongue and breathing >difficulties due an increased dose of trifluoperazine but once I got >home, I was okay for a day and a half before the tremors came on... How long between the increase of the trifluoperazine and the tremors? What dose before and after? -- Army Liason to the Office of Naval Contemplation >>I was thinking this morning that maybe I am having a reaction *to* the >>procyclidine - these tremors only really started once I began taking [quoted text clipped - 4 lines] > How long between the increase of the trifluoperazine and the >tremors? What dose before and after? I had been on 1mg of trifluoperazine three times a day for maybe four months. I went through a bad patch and my doc increased it to 5mg three times a day. Within two days I was in hospital with a bad reaction - I immedately sopped taking the drug. The tremors started about a day and a half later (I'd been taking 5mg Procyclidine three times a day since I left hospital). |
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