<<snip>>
sperm DNA damage can be efficiently treated with oral antioxidants
administered during a relatively short time period
<<snip>>

J Androl. 2005 May-Jun;26(3):349-53. Related Articles, Links

Reduction of the incidence of sperm DNA fragmentation by oral
antioxidant treatment.

Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J.

MAR&Gen, Gracia 36, 18002 Granada, Spain. cmendoza@ugr.es.

Sperm DNA fragmentation is known to compromise male fertility. Previous
findings have suggested the implication of oxidative stress in the
etiology of this pathological condition. The present study was
conducted to find out if the pathologically increased incidence of DNA
fragmentation in ejaculated spermatozoa can be reduced by oral
treatment with two antioxidants, vitamins C and E. Sixty-four men with
unexplained infertility and an elevated (>/=15%) percentage of
DNA-fragmented spermatozoa in the ejaculate were randomized between an
antioxidant treatment (1 g vitamin C and 1 g vitamin E daily for 2
months) group and a placebo group. Sperm DNA fragmentation was
evaluated by terminal deoxyribonucleotidyl transferase-mediated dUTP
nick-end labeling assay before and after treatment. No differences in
basic sperm parameters were found between the antioxidant treatment and
the placebo group before or after treatment. However, the percentage of
DNA-fragmented spermatozoa was markedly reduced (P < .001) in the
antioxidant treatment group after the treatment (9.1 +/- 7.2) as
compared with the pretreatment values (22.1 +/- 7.7). No difference in
the pretreatment and posttreatment incidence of sperm DNA fragmentation
was observed in the placebo group. These data show that sperm DNA
damage can be efficiently treated with oral antioxidants administered
during a relatively short time period.

PMID: 15867002 [PubMed - in process]

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