<<snip>>
Future research needs to focus on preventive medicine to DECREASE IRON
in patients with elevated lipids.
<<snip>>

Am J Cardiol. 2004 Mar 1;93(5):559-62. Links

Association of ferritin and lipids with C-reactive protein.

Mainous AG 3rd, Wells BJ, Everett CJ, Gill JM, King DE.

Department of Family Medicine, Medical University of South Carolina,
Charleston, South Carolina, USA.

C-reactive protein (CRP) and lipids (e.g., low-density lipoprotein
[LDL]) are both markers of cardiovascular disease risk, yet they are
not highly correlated. Oxidative stress of lipids induced by iron may
play a role in vascular inflammation, as indicated by CRP. The purpose
of this study was to examine, in a representative sample of United
States adults, the relation between ferritin, lipids, and CRP. We
analyzed data on adults (aged >/=25 years) in the National Health and
Nutrition Examination Survey III, a national public-use data set
collected between 1988 and 1994. Ferritin, total cholesterol, LDL,
high-density lipoprotein, and ferritin-lipid combinations were analyzed
in relation to CRP in age-, gender-, and race-adjusted models as well
as models with other potential confounding variables. In adjusted
models, neither elevated ferritin (odds ratio [OR] 1.11, 95% confidence
interval [CI] 0.94 to 1.32) nor elevated LDL was significantly
associated with elevated CRP (OR 1.03, 95% CI 0.79 to 1.33). Patients
with elevated ferritin and elevated LDL were more likely to have
elevated CRP (OR 1.68; 95% CI 1.06 to 2.68). Patients with elevated
ferritin and low high-density lipoprotein were also more likely to have
elevated CRP (OR 1.71; 95% CI 1.28 to 2.27). These results suggest that
both iron and lipids induce inflammation. Future research needs to
focus on preventive medicine to decrease iron in patients with elevated
lipids.

PMID: 14996579 [PubMed - in process]

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Infection or any type of inflammation.

Jeff