Thank you for the original post. In a paper entitled " Alanine
Aminotransferase and Cellular Transformation" (Copyright, 1977- Copyright
Registration No.: TX 127-939) which I presented to the Texas Medical
Association annual convention, I hypothesized  that a defect in the alanine
transaminase and lactate dehydrogenase reactions leads to the observed
metabolic characteristics of transformed (cancerous) cells. Both alanine and
lactate have the same molecular weights and number of valence electrons in
their natural biological states. Thus, a minimal defect in the alanine
aminotransferase reaction could result in many of the biochemical and
clinical manifestations of cancer.
Alanine inhibits tryptophan catabolism (break down). Tryptophan catabolic
products are precursors of Nicotinic Acid (Niacin). Tryptophan catabolic
products inhibit pyruvate oxidation. Tryptophan catabolism is inhibited by
alanine. Increased Niacin levels would, therefore, increase the alanine
concentration in cells that had not been transformed ( with the resultant
suppressive affect to the biochemical induction to cellular transformation)
and ,  at the same time, through the lactate dehydrogenase reaction in which
Pyruvate ( the precursor to both lactate and alanine), through increased
Niacin levels (both because of the increase in Niacin because of the
biochemical affects cellular transformation and the administration of
Niacin) (in which NADH donates H to pyruvate to form lactate) would have, if
anything, not a decrease in proliferation of transformed cells but,
probably, an increase in the proliferation of transformed cells. I am a
Registered Nurse and a Biochemist. Marcus Aurelius is not my real name.
----- Original Message -----
From: <ironjustice@aol.com>
Newsgroups:
alt.support.cancer,sci.med.diseases.cancer,sci.med.nutrition,sci.med
Sent: Tuesday, May 03, 2005 12:24 PM
Subject: Proliferation and invasion of cancer cells / niacin

Communication
Anti-Invasive Activity of Niacin and Trigonelline against Cancer Cells

Nobuhiro Hirakawa, Rieko Okauchi, Yutaka Miura, and Kazumi Yagasaki

Department of Applied Biological Science, Tokyo Noko University,
Saiwai-cho 3-5-8, Fuchu, Tokyo 183-8509, Japan

The effects of niacin, namely, nicotinic acid and nicotinamide, and
trigonelline on the proliferation and invasion of cancer cells were
studied using a rat ascites hepatoma cell line of AH109A in culture.
Niacin and trigonelline inhibited the invasion of hepatoma cells at
concentrations of 2.5-40 µM without affecting proliferation.
Hepatoma cells previously cultured with a reactive oxygen species
(ROS)-generating system showed increased invasive activity. Niacin and
trigonelline suppressed this ROS-potentiated invasive capacity through
simultaneous treatment of AH109A cells with the ROS-generating system.
The present study indicates for the first time the anti-invasive
activities of niacin and trigonelline against cancer cells.

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking