Cell Biochem Funct. 2005 Apr 13; [Epub ahead of print] Related
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Serum paraoxonase 1 activity and malondialdehyde levels in patients
with ulcerative colitis.

Baskol G, Baskol M, Yurci A, Ozbakir O, Yucesoy M.

Department of Biochemistry and Clinical Biochemistry, Erciyes
University School of Medicine, Kayseri, Turkey.

This study was designed to evaluate the oxidative and antioxidative
status in patients with ulcerative colitis by detecting antioxidant
enzyme paraoxonase 1 activity together with the level of a well-known
marker of oxidative stress, malondialdehyde. Serum paraoxonase 1
activity and malondialdehyde levels were analysed in 30 patients with
ulcerative colitis and 30 controls using a spectrophotometric method;
correlation analysis was made between these variables. Serum
malondialdehyde levels were higher in the ulcerative colitis group
(median: 2.5, range: 0.5-9.4 nmol ml(-1)) than among the controls
(median:1.1, range: 0.5-2.3 nmol ml(-1); p < 0.001) whereas paraoxonase
1 activities were lower in the ulcerative colitis group (median: 158.4,
range: 61.6-264.1 U l(-1)) than in the control group (median: 233.3,
range: 114.4-431.0 U l(-1); p < 0.001). There was no correlation
between serum malondialdehyde level, paraoxonase 1 activity and disease
activity. (1) Increased reactive oxygen metabolites levels in
ulcerative colitis may result in a pro-oxidation environment, which in
turn could result in decreased antioxidant paraoxonase 1 activity and
increased malondialdehyde levels, (2) increased cytokines may be a
possible cause of decreased paraoxonase 1 activity and (3) decreased
serum paraoxonase 1 activity may be a part of an inflammatory response.
Copyright (c) 2005 John Wiley & Sons, Ltd.

PMID: 15830398 [PubMed - as supplied by publisher]

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