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Medical Forum / General / General / April 2005R)-alpha-lipoic acid / IRON / neurodegenerative disorders
Redox Rep. 2005;10(1):52-60. Links Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Suh JH, Moreau R, Heath SH, Hagen TM. Department Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA. Accumulation of divalent metal ions (e.g. iron and copper) has been proposed to contribute to heightened oxidative stress evident in aging and neurodegenerative disorders. To understand the extent of iron accumulation and its effect on antioxidant status, we monitored iron content in the cerebral cortex of F344 rats by inductively coupled plasma atomic emission spectrometry (ICP-AES) and found that the cerebral iron levels in 24-28-month-old rats were increased by 80% (p<0.01) relative to 3-month-old rats. Iron accumulation correlated with a decline in glutathione (GSH) and the GSH/GSSG ratio, indicating that iron accumulation altered antioxidant capacity and thiol redox state in aged animals. Because (R)-alpha-Lipoic acid (LA) is a potent chelator of divalent metal ions in vitro and also regenerates other antioxidants, we monitored whether feeding LA (0.2% [w/w]; 2 weeks) could lower cortical iron and improve antioxidant status. Results show that cerebral iron levels in old LA-fed animals were lower when compared to controls and were similar to levels seen in young rats. Antioxidant status and thiol redox state also improved markedly in old LA-fed rats versus controls. These results thus show that LA supplementation may be a means to modulate the age-related accumulation of cortical iron content, thereby lowering oxidative stress associated with aging. PMID: 15829111 [PubMed - in process] -------------------------------------------------------------------------------- Who loves ya. Tom Jesus Was A Vegetarian! http://herbivore.7h.com I'm no fan of Doe- Nut, but even a broken clock is right twice a day. The evidence for oxidative stress and MS is compelling. As someone who did his master's thesis on antioxidants and disease, ALA is the most potent antioxidant known to man at this point IMO. This recent research is one of quite a few and should be taken seriously. Chuck > I'm no fan of Doe- Nut, but even a broken clock is right twice a day. > The evidence for oxidative stress and MS is compelling. As someone who [quoted text clipped - 3 lines] > > Chuck Where is ALA mentioned in that article above? Masters thesis on antioxidants and disease? Give me a break dude. You looked at all diseases and related them to antioxidants. That is impressive (chuckle). I hate to think what your PhD thesis will be. What about oxygen and the origins of life? All damaged tissue is susceptible to oxidative stress and that doesn't not mean that it is the primary defect but only that the damaged tissue is terminally damaged by oxidation. With MS it is the antibody that causes the initial damage. If you live in a submarine and get a little hole in the structure then the water will crush you. It is not the water that is the primary defect but it will definitely kill you. >Masters thesis on antioxidants and disease? Give me a break >dude. >Robert Antioxidants and Cardiovascular Disease (CVD) to be specific *Dude*. My Doctoral thesis will likely be in the area of Nitric Oxide (NO). I skimmed the title of Doe-Nut's study. Since I had recently read the study below I had thought he was to referring that. Silly me to think that the doe-man might post something pertinent to MS to an MS newsgroup. Having done some recent research on theories of oxidative stress and MS, the study below is very compelling IMO. Chuck PS: I never said Oxidative Stress *caused* MS 1: Mult Scler. 2005 Apr;11(2):159-65. Related Articles, Links Lipoic acid in multiple sclerosis: a pilot study. Yadav V, Marracci G, Lovera J, Woodward W, Bogardus K, Marquardt W, Shinto L, Morris C, Bourdette D. Department of Veterans Affairs Medical Center, Portland, OR, USA. Lipoic acid (LA) is an antioxidant that suppresses and treats an animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis. The purpose of this study was to determine the pharmacokinetics (PK), tolerability and effects on matrix metalloproteinase-9 (MMP-9) and soluble intercellular adhesion molecule-1 (sICAMP-1) of oral LA in patients with MS. Thirty-seven MS subjects were randomly assigned to one of four groups: placebo, LA 600 mg twice a day, LA 1200 mg once a day and LA 1200 mg twice a day. Subjects took study capsules for 14 days. We found that subjects taking 1200 mg LA had substantially higher peak serum LA levels than those taking 600 mg and that peak levels varied considerably among subjects. We also found a significant negative correlation between peak serum LA levels and mean changes in serum MMP-9 levels (T = -0.263, P =0.04). There was a significant dose response relationship between LA and mean change in serum sICAM-1 levels (P =0.03). We conclude that oral LA is generally well tolerated and appears capable of reducing serum MMP-9 and sICAM-1 levels. LA may prove useful in treating MS by inhibiting MMP-9 activity and interfering with T-cell migration into the CNS. > >Masters thesis on antioxidants and disease? Give me a break >dude. > >Robert > > Antioxidants and Cardiovascular Disease (CVD) to be specific *Dude*. OK, how do we prevent CVD with antioxidants? My > Doctoral thesis will likely be in the area of Nitric Oxide (NO). You mean the the stuff viagra has made billions on? Let's see, viagra was originally developed for high blood pressure but because people were getting wood then all of a sudden the urologists got involved. I love the way science works, by accident and not high bloated ego inflating preconcieved notions. I > skimmed the title of Doe-Nut's study. Since I had recently read the > study below I had thought he was to referring that. Silly me to think > that the doe-man might post something pertinent to MS to an MS > newsgroup. Having done some recent research on theories of oxidative > stress and MS, the study below is very compelling IMO. Chuck > PS: I never said Oxidative Stress *caused* MS It absolutely does. It causes most to the damage involved in disease. It is not just the primary defect but the last nail on the coffin. > 1: Mult Scler. 2005 Apr;11(2):159-65. Related Articles, Links > [quoted text clipped - 23 lines] > and sICAM-1 levels. LA may prove useful in treating MS by inhibiting > MMP-9 activity and interfering with T-cell migration into the CNS. I suggest you read the intent of the specific study. "The purpose of this study was to determine the pharmacokinetics (PK), tolerability and effects on matrix metalloproteinase-9 (MMP-9) and soluble intercellular adhesion molecule-1 (sICAMP-1) of oral LA in patients with MS." Nothing more and nothing less. The speculative end statement is a plea for funding. You must tell people how you are going to save millions of lives by them giving you money for you to do research. The rock stars of research right now are oxidant and inflammatory people and tomorrow it will be something else. Get you PhD while it's hot and get retrained later on when it gets cold. >You mean the the stuff viagra has made billions on? And what is wrong with someone making a profit while improving the quality of life of millions? We all know that you work for nothing, and do not seek a profit. Somehow when it comes to healthcare, all of the sudden the belief surfaces that it should be all charity. >viagra was originally developed for high blood pressure Anti-angina medication to be more specific. Nitric Oxide is a potent vasodilator. Very fascinating compound with exponential research findings recntly in regard to health and disease. >RE: Oxstress. It absolutely does. It causes most to the >damage involved in disease. Many disease yes, ie: diabetes, among many IMO. I do not believe that OS is the original causative factor in MS. Otherwise *billions* would have MS as most have excessive "lipid" peroxidation (as in the myelin sheath) verse antioxidant defense and thus are in negative redox balance. >plea for funding. You sound bitter that someone may need money to conduct research. But in general you just sound bitter. About what I have no idea. Again I ask if you work for free? If funding can help wipe out this nasty bastard known as MS then bring it on! > >You mean the the stuff viagra has made billions on? > > And what is wrong with someone making a profit while improving the > quality of life of millions? We all know that you work for nothing, and > do not seek a profit. Somehow when it comes to healthcare, all of the > sudden the belief surfaces that it should be all charity. I never said that. Only that they made billions by chance and not by research on what it was intended for. > >viagra was originally developed for high blood pressure > > Anti-angina medication to be more specific. Nitric Oxide is a potent > vasodilator. Very fascinating compound with exponential research > findings recntly in regard to health and disease. It was developed for high blood pressure. The target market population is greater than for simply anigina. It is now being used for hypertrophy again related to high blood pressure. They want the market shares. > >RE: Oxstress. It absolutely does. It causes most to the >damage > involved in disease. [quoted text clipped - 4 lines] > sheath) verse antioxidant defense and thus are in negative redox > balance. Thats correct and that is my point. > >plea for funding. > > You sound bitter that someone may need money to conduct research. Not bitter just don't like their pimp sales pitch after every research article. It's like lets make a wish and hope it happens. There are sick people out there and you pimp research out there like a pimp and his ho. What do you think the people with MS are thinking when they read that hyperbole? Do you think they will follow up on that promise that it will be used in treatment protocols? Hell no. They could care less about it. Here a good one from Lovera J before he was involved with this one. J Allergy Clin Immunol. 1976 Feb;57(2):112-23. Related Articles, Books, LinkOut Clinical and physiological assessment of asthmatic children treated with beclomethasone dipropionate. Lovera J, Cooper DM, Collins-Williams C, Levison H, Bailey JD, Orange RP. Forty-two perennial asthmatic children were selected for a 12-wk study using beclomethasone dipropionate. The groups included 21 steroid-dependent children (Group I) and 21 patients (Group II) whose disease was of sufficient severity that corticosteroid therapy was contemplated. All children received the drug in a dose of 100 mug 4 times daily. During the study, oral prednisone was withdrawn from the steroid-dependent children while other therapy was essentially unchanged. Group II children underwent a double-blind trial, receiving beclomethasone for 6 wk and placebo for 6 wk. Objective assessment of adrenal and pulmonary function was obtained at regular intervals. For the latter, total lung capacity and its subdivisions, airways resistance, maximum expiratory flow volume, and oxygen tension, were measured in both groups. In Group II static elastic recoil was measured also. For most tests the results were statistically significant. In both groups, 18 of 21 patients demonstrated an excellent clinical response, no evidence of adrenal suppression, and improvement in pulmonary function. Forty of 42 patients were followed for another 12 wk, and 19 of each group did well. After 20-24 wk of therapy, 16% of patients harbored monilia in their oropharynx, and 1 patient had clinical monilial stomatitis. Within the limits of the time of the study, beclomethasone dipropionate appeared to provide adequate clinical control in many chronic, severe, steroid-dependent and nonsteroid-dependent asthmatic children. Publication Types: Clinical Trial Controlled Clinical Trial PMID: 765382 [PubMed - indexed for MEDLINE] The guy is a real pro and very versatile. He does research for a living. He loves it. But > in general you just sound bitter. About what I have no idea. Again I > ask if you work for free? If funding can help wipe out this nasty > bastard known as MS then bring it on! Professional researchers make a living at doing research whether it helps anybody or not. The cleaver ones are the ones who raise the hopes of the sick and play off their illness in seeking funds. Break through often come from unrelated fields and not from the professional researchers doing the specific field. As I was trying to say about impotence as much research was done on that field and they came up with nothing. Viagra comes along and all of a sudden they are all experts on NO. Give me a break. > by chance and not by >research on what it was intended for. LOL Many, many *MANY*, scientific findings throughout history have come to fore this way. And it is usually a good and not a bad thing. If someone comes across a cure for cancer while researching the role of folic acid in cell replication, I'd be pretty damn happy! > > by chance and not by > >research on what it was intended for. [quoted text clipped - 3 lines] > someone comes across a cure for cancer while researching the role of > folic acid in cell replication, I'd be pretty damn happy! I never said it was bad only that the sales pitch of the researcher does not really contribute to his success or not. It only contributes to his income. By the way that researcher did not find the cause of asthma before he moved on did he? They go from A-Z and are not dedicated to any disease only to their own research or to publish. >Only that they made billions by chance and not by >research on what it was intended for. When I worked in development one of the gurus would often say, "Our plans are unsuccessful. Our successes are unplanned." <steve@tropheus.demon.co.uk> > Is a crossposting idiot. > Stop crossposters by using this message as [quoted text clipped - 4 lines] > the sooner they'll learn. > Keep The Internet Free - of Idiots Andrew >When I worked in development one of the >gurus would often say, >"Our plans are unsuccessful. Our >successes are unplanned." Great quote! "The history of science is science itself" |
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