Oxidative stress and endometriosis

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ironjustice@aol.com - 11 Apr 2005 15:16 GMT

Hum Reprod. 2005 Apr 7; [Epub ahead of print] Related Articles, Links

Oxidative stress and endometriosis.

Jackson LW, Schisterman EF, Dey-Rao R, Browne R, Armstrong D.

Division of Epidemiology, Statistics, and Prevention Research, National
Institute of Child Health and Human Development, National Institutes of
Health, Department of Health and Human Services, Rockville, MD 20852,
USA.

BACKGROUND: Little is known about the aetiology of endometriosis;
however, in the presence of oxidative stress, reactive oxygen species
might increase growth and adhesion of endometrial cells in the
peritoneal cavity, leading to endometriosis and infertility. Within a
study investigating persistent organic compounds and endometriosis, the
authors evaluated the association between oxidative stress and
endometriosis. METHODS: Women aged 18-40 years who were undergoing
laparoscopy were contacted to participate in the study (n=100); 84 were
eligible and agreed to be interviewed; 78 provided blood specimens.
Four markers of oxidative stress and antioxidant status were measured
in serum for 61 women. Multiple imputation of missing data was used to
generate values for the missing oxidative stress data. RESULTS:
Thirty-two women had visually confirmed endometriosis at laparoscopy
while 52 did not, including 22 undergoing tubal ligation and 30 with
idiopathic infertility. There was a weak association between
thiobarbituric acid-reactive substances (nmol/ml) and endometriosis,
after adjusting for age, body mass index, current smoking, hormone use
in the past 12 months, gravidity, serum vitamin E, serum estradiol, and
total serum lipids (beta=1.18; 95% CI-0.04, 2.39). CONCLUSIONS: These
results suggest that oxidative stress might play a role in the
development and progression of endometriosis, which should be evaluated
in larger studies.

PMID: 15817589 [PubMed - as supplied by publisher]

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Robert - 11 Apr 2005 18:24 GMT

> Hum Reprod. 2005 Apr 7; [Epub ahead of print] Related Articles, Links
>
> Oxidative stress and endometriosis.

Oxidative stress can be found in all cell damage from any origin. An
unhealthy cell is unable to resist the stress.

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ironjustice@aol.com - 12 Apr 2005 09:45 GMT

Fertil Steril. 2002 Oct;78(4):712-8. Related Articles, Links

Iron overload in the peritoneal cavity of women with pelvic
endometriosis.

Van Langendonckt A, Casanas-Roux F, Donnez J.

Department of Gynecology, Universite Catholique de Louvain, Brussels,
Belgium.

OBJECTIVE: To examine the possible involvement of iron in the
physiopathology of endometriosis. DESIGN: Prospective study. SETTING:
Department of gynecology in a university hospital. PATIENT(S): Seventy
patients undergoing laparoscopy. INTERVENTION(S): Collection of
peritoneal fluid (n = 57), blood samples, and biopsy samples from
endometrium (n = 62) and from endometriotic (n = 33) and
normal-appearing peritoneum (n = 53). MAIN OUTCOME MEASURE(S):
Measurement of iron and ferritin in serum and peritoneal fluid and
staining of iron deposits with Prussian blue in tissues. RESULT(S):
Iron and ferritin concentrations were significantly higher in the
peritoneal fluid of patients with endometriosis compared with controls
during the secretory phase. Higher rates of ferritin and hemosiderin
deposits were observed in the peritoneum adjacent to red (100%), black
(57%), and white (62%) lesions compared with normal-appearing
peritoneum (25%). Deposits were more frequent during the secretory
phase than the proliferative phase in healthy peritoneum from controls,
whereas they were found throughout the cycle in the vicinity of lesions
in patients with endometriosis. Similar rates of iron deposition were
observed in the stroma of black and white lesions and in eutopic
endometrium from patients with endometriosis. CONCLUSION(S): Iron
overload was observed in the cellular and peritoneal fluid compartments
of the peritoneal cavity of women with endometriosis. Iron deposits
seem to be related to the presence of lesions, suggesting that iron may
be involved in the pathogenesis of endometriosis.

PMID: 12372445 [PubMed - indexed for MEDLINE]

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Jesus Was A Vegetarian!
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